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MLN9708

MLN9708 is a drug used to treat Multiple Myeloma, Acute Leukemia, Advanced Cancers, and other conditions. MLN9708 is being actively studied in 4 studies and prior, has been studied in 7.

Top SponsorsTop SitesTop Investigators
Dartmouth-Hitchcock Medical CenterFroedtert Hospital and the Medical College of WisconsinEhab L Atallah
Ehab L AtallahDartmouth-Hitchcock Medical CenterGary Schwartz
GWT-TUD GmbHAO SS Antonio e Biagio e Cesare Arrigo di AlessandriaJason Valent
STUDY
CONDITIONS
INTERVENTIONS
LOCATIONS
LAST UPDATED
M
STUDY THAT COMPARE 3 ARM: MLN9708 DEXAMETHASONE, MLN9708 CYCLOPHOSPHAMIDE AND DEXAMETHASONE, MLN9708 THALIDOMIDE AND DEXAMETHASONE FOLLOWED BY MAINTENANCE WITH MLN9708 IN NEWLY DIAGNOSED ELDERLY MULTIPLE MYELOMA PATIENTS
Active, not recruiting
  • Multiple Myeloma
  • MLN9708
  • +3 more
  • Alessandria, Italy
    AO SS Antonio e Biagio e Cesare Arrigo di Alessandria
2021-04-27
Apr 27, 2021
M
MLN9708 for the Prophylaxis of Chronic Graft-versus-host Disease in Patient Undergoing Allogeneic Transplantation - 2020
Completed
  • Allogeneic Hematopoietic Stem Cell Transplantation
  • MLN9708
  • Milwaukee, Wisconsin
    Froedtert Hospital and the Medical College of Wisconsin
2020-11-01
Nov 1, 2020
N
Nonmyeloablative Haploidentical Transplant Followed by MLN9708 - 2020
Completed
Has Results
  • Acute Leukemia
  • +4 more
  • MLN9708
  • Atlanta, Georgia
    Northside Hospital
2021-09-01
Sep 1, 2021
N
MLN9708 and Dexamethasone for High-Risk Smoldering Multiple Myeloma - 2014
Withdrawn
  • Multiple Myeloma
  • (no location specified)
2019-12-13
Dec 13, 2019
S
Determining the Feasibility of MLN9708 as Maintenance After Allogeneic Stem Cell Transplant for Multiple Myeloma - 2019
Completed
Has Results
  • Multiple Myeloma
  • MLN9708
  • Denver, Colorado
  • +3 more
2020-02-13
Feb 13, 2020
M
MLN 9708 in Induction and Consolidation for Adults With AML >= 60 Years of Age
Recruiting
  • Acute Myeloid Leukemia
  • MLN9708
  • +2 more
  • Boston, Massachusetts
    Massachusetts General Hospital
2021-01-18
Jan 18, 2021
J
MLN9708 (Ixazomib) in Combination With Panobinostat and Dexamethasone in Multiple Myeloma - 2018
Completed
Has Results
  • Multiple Myeloma
  • +3 more
  • Cleveland, Ohio
  • +1 more
2019-12-10
Dec 10, 2019
P
Study of Bendamustine and IXAZOMIB (MLN9708) Plus Dexamethasone in Relapsed/Refractory Multiple Myeloma - 2020
Completed
Has Results
  • Multiple Myeloma
  • MLN9708
  • +3 more
  • Milwaukee, Wisconsin
    Froedtert Hospital and the Medical College of Wisconsin
2020-09-30
Sep 30, 2020
M
MLN9708 and Vorinostat in Patients With Advanced p53 Mutant Malignancies
Active, not recruiting
  • Advanced Cancers
  • Houston, Texas
    University of Texas MD Anderson Cancer Center
2019-05-21
May 21, 2019
D
Phase I Study of the Combination of MLN9708 and Fulvestrant - 2018
Terminated
  • Breast Cancer
  • Lebanon, New Hampshire
    Dartmouth-Hitchcock Medical Center
2019-04-25
Apr 25, 2019
N
Safety and Efficacy Study of a Triplet Combination of MLN9708, Lenalidomide and Dexamethasone in the Initial Management of Multiple Myeloma (IFM2013-06)
Unknown status
  • Newly Diagnosed Multiple Myeloma
  • MLN9708
  • +2 more
  • Bordeaux, France
  • +9 more
2020-02-18
Feb 18, 2020
E
Vincristine, Doxorubicin, And Dexamethasone + Ixazomib in Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma Or Mixed Phenotype Acute Leukemia - 2016
Terminated
Has Results
  • Relapsed or Refractory Acute Lymphoblastic Leukemia
  • +2 more
  • MLN9708
  • +3 more
  • Milwaukee, Wisconsin
    Froedtert Hospital and the Medical College of Wisconsin
2019-12-30
Dec 30, 2019
G
Pomalidomide, Ixazomib, and Dexamethasone With or Without Intensification by Cyclophosphamide in Relapsed or Refractory Multiple Myeloma
Recruiting
  • Refractory Multiple Myeloma
  • MLN9708
  • +3 more
  • Munich, Bayern, Germany
  • +10 more
2021-09-08
Sep 8, 2021
D
Dose Escalation Study of Nelfinavir Plus MLN9708 in Patients With Advanced Solid Tumors or Lymphoma
Withdrawn
  • Neoplasms
  • Lymphoma
  • Lebanon, New Hampshire
    Dartmouth-Hitchcock Medical Center
2018-01-30
Jan 30, 2018
U
Open-label, Phase II Study of MLN9708 in Patients With Relapsed/Refractory Cutaneous and Peripheral T-cell Lymphomas - 2016
Completed
Has Results
  • Lymphoma, T-Cell
  • MLN9708
  • Ann Arbor, Michigan
    University of Michigan Hospital
2017-10-10
Oct 10, 2017
P
Trial Studying Maintenance Treatment With Lenalidomide and Dexamethasone Versus Lenalidomide, Dexamethasone and MLN9708 After Autologous Hematopoietic Stem Cell Transplantation in Patients With Newly-diagnosed Symptomatic Multiple Myeloma - 2017
Completed
  • Multiple Myeloma
  • MLN9708
  • +2 more
  • A Coruña, Spain
  • +73 more
2017-11-28
Nov 28, 2017