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entinostat

Entinostat is a drug used to treat Breast Cancer, Recurrent Adult Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, and other conditions. Entinostat is being actively studied in 21 studies and prior, has been studied in 23.

Top SponsorsTop SitesTop Investigators
National Cancer Institute (NCI)Johns Hopkins University/Sidney Kimmel Cancer CenterRoberto Pili
Syndax PharmaceuticalsRoswell Park Cancer InstituteAntonio Fojo
Roberto PiliMemorial Sloan Kettering Cancer CenterJianqing Lin
STUDY
CONDITIONS
INTERVENTIONS
LOCATIONS
LAST UPDATED
A
Entinostat Neuroendocrine (NE) Tumor
Recruiting
  • Neuroendocrine Tumors
  • Entinostat
  • New York, New York
    Columbia University Medical Center
2021-10-06
Oct 6, 2021
A
A Study of Entinostat and FOLFOX in Subjects With Pancreatic Adenocarcinoma
Withdrawn
  • Pancreas Cancer
  • Entinostat
  • FOLFOX regimen
  • (no location specified)
2021-01-13
Jan 13, 2021
S
A Clinical Trial of Entinostat in Combination With Nivolumab for Patients With Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Adenocarcinoma
Active, not recruiting
  • Previously Treated Unresectable or Metastatic Cholangiocarcinoma and Pancreatic Cancer
  • +3 more
  • Baltimore, Maryland
    Sidney Kimmel Comprehensive Cancer Center
2021-08-18
Aug 18, 2021
U
An Exploratory Study of Pembrolizumab Plus Entinostat in Non-Inflamed Stage III/IV Melanoma
Recruiting
  • Melanoma
  • Chapel Hill, North Carolina
    UNC Lineberger Comprehensive Cancer Center
2021-05-08
May 8, 2021
A
Phase I/II Trial of Regorafenib, Hydroxychloroquine, and Entinostat in Metastatic Colorectal Cancer - 2020
Completed
  • Colorectal Cancer
  • Philadelphia, Pennsylvania
    Abramson Cancer Center of the University of Pennsylvania
2020-12-16
Dec 16, 2020
S
Study to Assess Food Effect on Pharmacokinetics of Entinostat in Subjects With Breast Cancer or Non-Small Cell Lung Cancer - 2014
Completed
  • Lung Cancer
  • +3 more
  • entinostat
  • +2 more
  • Sarasota, Florida
  • +2 more
2021-11-11
Nov 11, 2021
G
Combination of Entinostat and Enzalutamide in Advanced Prostate Cancer - 2020
Terminated
  • Prostate Adenocarcinoma
  • Washington, District of Columbia
    George Washington University - Medical Faculty Associates
2021-07-26
Jul 26, 2021
R
Study of Entinostat With Nivolumab Plus Ipilimumab in Previously Treated Renal Cell Carcinoma
Active, not recruiting
  • Renal Cell Carcinoma
  • Entinostat
  • +2 more
  • Washington, District of Columbia
  • +1 more
2021-07-26
Jul 26, 2021
N
Phase I/II Trial of the Combination of Bintrafusp Alfa (M7824), Entinostat and NHS-IL12 (M9241) in Patients With Advanced Cancer
Suspended
  • Cancer
  • +3 more
  • Bintrafusp Alfa
  • +2 more
  • Bethesda, Maryland
    National Institutes of Health Clinical Center
2021-10-19
Oct 19, 2021
U
Window of Opportunity Trial of Entinostat in Patients With Newly Diagnosed Stage I-IIIC,TNBC - 2019
Terminated
  • Breast Cancer
  • +2 more
  • Entinostat
  • Chapel Hill, North Carolina
    Lineberger Comprehensive Cancer Center at University of North Ca
2021-03-22
Mar 22, 2021
R
Atezolizumab in Combination With Entinostat and Bevacizumab in Patients With Advanced Renal Cell Carcinoma
Active, not recruiting
  • Metastatic Cancer
  • Renal Cancer
  • Indianapolis, Indiana
  • +3 more
2021-07-09
Jul 9, 2021
N
Testing A New Anti-cancer Drug Combination, Entinostat and ZEN003694, for Advanced and Refractory Solid Tumors and Lymphomas
Not yet recruiting
  • Advanced Lymphoma
  • +13 more
  • BET Bromodomain Inhibitor ZEN-3694
  • Entinostat
  • (no location specified)
2021-11-05
Nov 5, 2021
T
Ph3 Study of Exemestane With or Without Entinostat in Chinese Patients With Hormone Receptor-Positive, Locally Advanced or Metastatic Breast Cancer
Active, not recruiting
  • Advanced Breast Cancer
  • Entinostat
  • +2 more
  • Beijing, Beijing, China
    Cancer Hospital Chinese Academy Medical Sciences
2021-07-07
Jul 7, 2021
U
A Pilot Study of the Combination of Entinostat With Capecitabine in High Risk Breast Cancer After Neo-adjuvant Therapy
Recruiting
  • Metastatic Breast Cancer
  • Breast Cancer
  • Rochester, New York
  • +1 more
2020-09-11
Sep 11, 2020
M
Combination Therapy With Entinostat and Pembrolizumab in Relapsed and Refractory Lymphomas
Recruiting
  • Lymphoma
  • +2 more
  • Evanston, Illinois
  • +8 more
2021-07-08
Jul 8, 2021
V
Olaparib and Entinostat in Patients With Recurrent, Platinum-Refractory, Resistant Ovarian, Primary Peritoneal, Fallopian Tube Cancers
Recruiting
  • Fallopian Tube Cancer
  • +12 more
  • Kansas City, Kansas
  • +1 more
2021-07-14
Jul 14, 2021
N
Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer
Active, not recruiting
Has Results
  • Male Breast Carcinoma
  • +4 more
  • Duarte, California
  • +6 more
2021-06-12
Jun 12, 2021
R
High Dose IL 2 and Entinostat in RCC
Active, not recruiting
  • Renal Cell Carcinoma
  • Los Angeles, California
  • +4 more
2020-09-11
Sep 11, 2020
N
Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas - 2020
Withdrawn
  • Advanced Lymphoma
  • +16 more
  • (no location specified)
2020-09-25
Sep 25, 2020
N
Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer
Active, not recruiting
Has Results
  • Clear Cell Renal Cell Carcinoma
  • +3 more
  • Aldesleukin
  • +6 more
  • Los Angeles, California
  • +3 more
2021-02-09
Feb 9, 2021
N
Testing the Safety and Efficacy of the Combination of the Antibody Pembrolizumab and Entinostat in Patients With Myelodysplastic Syndrome Who Are Not Responding to Hypomethylating Agents
Active, not recruiting
  • Myelodysplastic Syndrome
  • Entinostat
  • Pembrolizumab
  • New Haven, Connecticut
  • +18 more
2021-07-01
Jul 1, 2021
V
Efficacy Study of Pembrolizumab With Entinostat to Treat Metastatic Melanoma of the Eye
Active, not recruiting
  • Metastatic Uveal Melanoma
  • Gothenburg, Västra Götaland Region, Sweden
    Department of oncology, Sahlgrenska University Hospital
2019-10-15
Oct 15, 2019
N
Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread
Suspended
  • Extensive Stage Lung Small Cell Carcinoma
  • +2 more
  • Atezolizumab
  • +3 more
  • New York, New York
  • +4 more
2021-09-30
Sep 30, 2021
U
Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer
Recruiting
  • Bladder Cancer
  • Chapel Hill, North Carolina
    Lineberger Comprehensive Cancer Center
2021-02-18
Feb 18, 2021
S
Phase II Anti-PD1 Epigenetic Therapy Study in NSCLC.
Recruiting
  • Non-Small Cell Lung Cancer
  • Epigenetic Therapy
  • Los Angeles, California
  • +4 more
2021-06-03
Jun 3, 2021