Major Depressive Disorder Clinical Trials

STUDY
CONDITIONS
INTERVENTIONS
LOCATIONS
LAST UPDATED
C
Intensive tDCS for MDD: Feasibility Study
Not yet recruiting
  • Major Depressive Disorder
  • transcranial direct current stimulation (tDCS)
  • Montréal, Quebec, Canada
    Centre Hospitalier de l'Université de Montréal (CHUM)
2022-01-04
Jan 4, 2022
J
A Study of HS-10353 in Chinese Participants.
Enrolling by invitation
  • Major Depressive Disorder
  • Chengdu, Sichuan, China
    West China Hospital
2022-01-13
Jan 13, 2022
S
Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression
Recruiting
  • Major Depressive Disorder
  • TMS: single session intermittent theta burst stimulation (iTBS) to dorsomedial prefrontal target in individuals with major depressive disorder, via MagVenture MagPro R30 device / Cool-DB80 A/P coil
  • SHAM (inactive) TMS stimulation
  • San Francisco, California
    San Francisco VA Medical Center
2022-01-03
Jan 3, 2022
N
A Feasibility Study of Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Not yet recruiting
  • Major Depressive Disorder
  • +2 more
  • MagPro TMS Stimulator and coil
  • +3 more
  • Bethesda, Maryland
    National Institutes of Health Clinical Center
2022-01-13
Jan 13, 2022
N
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
Recruiting
  • Healthy Volunteer
  • +2 more
  • Bethesda, Maryland
    National Institutes of Health Clinical Center
2022-01-13
Jan 13, 2022
C
Home-Based CR and tDCS to Enhance Cognition in Persons With Mild Cognitive Impairment and Late Life Depression
Active, not recruiting
  • Mild Cognitive Impairment
  • +4 more
  • Receive tDCS+CR
  • Facilitate tDCS + CR
  • Toronto, Ontario, Canada
    Centre for Addiction and Mental Health
2022-01-13
Jan 13, 2022
M
KAP for Depression in Abstinent Opioid Users
Recruiting
  • Opioid Use Disorder, Severe, in Sustained Remission
  • +2 more
  • Ketamine-assisted psychotherapy
  • Charleston, South Carolina
    Medical University of South Carolina Centerspace
2021-12-30
Dec 30, 2021
N
Study to Evaluate the Efficacy and Safety of Once-Weekly Oral NBI-1065846 in the Treatment of Anhedonia in MDD
Recruiting
  • Anhedonia
  • Major Depressive Disorder
  • Oklahoma City, Oklahoma
    Neurocrine Clinical Site
2022-01-12
Jan 12, 2022
N
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes
Recruiting
  • Major Depressive Disorder
  • MagPro X100 TMS Therapy System
  • +5 more
  • Bethesda, Maryland
    National Institutes of Health Clinical Center
2022-01-11
Jan 11, 2022
S
An Investigation of the Relationship Between Omega-3 Fatty Acid Nutrition and Mental Health in Children and Adolescents - 2020
Completed
  • Major Depressive Disorder
  • +2 more
    • Zürich, Switzerland
      ETH Zürich
    2022-01-07
    Jan 7, 2022
    U
    A Personalized Approach to Effects of Affective Bias Modification on Symptom Change and Rumination
    Active, not recruiting
    • Major Depressive Disorder
    • Affective bias modification
    • Sham Affective bias modification
    • Oslo, Norway
      Department of Psychology
    2022-01-10
    Jan 10, 2022
    M
    Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
    Recruiting
    • Major Depressive Disorder
    • Depression
    • Pittsburgh, Pennsylvania
      Bellefield Tower
    2022-01-06
    Jan 6, 2022
    U
    Adjunctive D-Cycloserine in Major Depressive Disorder - 2020
    Completed
    • Major Depressive Disorder
    • Calgary, Alberta, Canada
      University of Calgary
    2022-01-06
    Jan 6, 2022
    H
    Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)
    Recruiting
    • Major Depressive Disorder
    • Escitalopram Pill
    • +2 more
    • Pittsburgh, Pennsylvania
      University of Pittsburgh
    2022-01-05
    Jan 5, 2022
    A
    Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder
    Not yet recruiting
    • Major Depressive Disorder
    • SSRI+ Placebo
    • SSRI+ Dextromethorphan
    • (no location specified)
    2021-12-16
    Dec 16, 2021
    U
    Effects of Amygdala Neurofeedback on Depressive Symptoms - 2020
    Completed
    • Major Depressive Disorder
    • real-time fMRI neurofeedback: Amygdala
    • real-time fMRI neurofeedback: HIPS
    • Pittsburgh, Pennsylvania
      University of Pittsburgh
    2022-01-05
    Jan 5, 2022
    N
    Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes
    Recruiting
    • Anxiety Disorders
    • Major Depressive Disorder
    • Bethesda, Maryland
      National Institutes of Health Clinical Center, 9000 Rockville Pi
    2022-01-05
    Jan 5, 2022
    U
    Rapid Antidepressant Effects of Leucine - 2021
    Terminated
    • Major Depressive Disorder
    • Dallas, Texas
      University of Texas Southwestern Medical Center
    2022-01-03
    Jan 3, 2022
    U
    Cycloserine rTMS Plasticity Augmentation in Depression - 2021
    Completed
    • Major Depressive Disorder
    • Calgary, Alberta, Canada
      University of Calgary
    2022-01-04
    Jan 4, 2022
    B
    A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients
    Not yet recruiting
    • Major Depressive Disorder
    • PDC-1421 Capsule
    • Los Angeles, California
      Cedars-Sinai Health System
    2022-01-04
    Jan 4, 2022
    S
    Closed-loop Optimized rTMS for Depression
    Recruiting
    • Major Depressive Disorder
    • closed-loop rTMS
    • +2 more
    • Stanford, California
      Stanford University
    2022-01-04
    Jan 4, 2022
    A
    ALTO-300 in Depression
    Recruiting
    • Major Depressive Disorder
    • ALTO-300 PO tablet
    • Dallas, Texas
      Site 102
    2022-01-03
    Jan 3, 2022
    U
    Spinal Cord Stimulation for the Treatment of Major Depressive Disorder
    Recruiting
    • Major Depressive Disorder
    • Active transcutaneous spinal direct current stimulation
    • Sham transcutaneous spinal direct current stimulation
    • Mason, Ohio
      Lindner Center of HOPE/University of Cincinnati
    2022-01-03
    Jan 3, 2022
    N
    Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer
    Not yet recruiting
    • Major Depressive Disorder
    • +2 more
    • Interpersonal Psychotherapy
    • Venlafaxine HCl ER
    • (no location specified)
    2022-01-03
    Jan 3, 2022
    U
    Electroconvulsive Therapy Amplitude Titration
    Recruiting
    • Major Depressive Disorder
    • Mecta Spectrum 5000Q paired with Soterix Medical 4X1 HD - ECT Multi-Channel Stimulation Interface
    • Albuquerque, New Mexico
      University of New Mexico
    2022-01-02
    Jan 2, 2022