Abdominal Aortic Aneurysm Screening Before Coronary Artery Bypass Surgery

• Sponsor: Basaksehir Cam & Sakura Şehir Hospital (Other)
• Overall Status: Not yet recruiting
• CT.gov ID: NCT05449509
• Collaborator: (none)
• Enrollment: 170
• Anticipated Duration (Months): 12.5

Study Details

Study Description

Brief Summary

Coronary artery disease (CAD) and abdominal aortic aneurysm (AAA) are two separate entities with common risk factors such as hypertension, advanced age, male sex. Atherosclerosis plays an important role in the etiology of both diseases. It has been reported that AAA is more prevalent in patients undergoing coronary artery bypass grafting (CABG). Despite all the evidence, current guidelines do not recommend routine screening for AAA before CABG. Syntax score shows anatomical significance of CAD and is associated with the degree of atherosclerotic load. The investigators aim to investigate if there were any differences regarding AAA prevalence in high-SYNTAX patients versus intermediate/low-SYNTAX patients.

Condition or Disease	Intervention/Treatment	Phase
Coronary Artery Disease; Abdominal Aortic Aneurysm	Diagnostic Test: Abdominal aortic Duplex ultrasound

Study Design

• Study Type: Observational
• Anticipated Enrollment: 170 participants
• Observational Model: Other
• Time Perspective: Cross-Sectional
• Official Title: Association of SYNTAX Score With Abdominal Aortic Aneurysm in Patients Undergoing Coronary Artery Bypass Graft Surgery: Who Should be Screened?
• Anticipated Study Start Date: Aug 15, 2022
• Anticipated Primary Completion Date: Aug 15, 2023
• Anticipated Study Completion Date: Aug 30, 2023

Arms and Interventions

Arm	Intervention/Treatment
High-SYNTAX score patients	Diagnostic Test: Abdominal aortic Duplex ultrasound; All patients will undergo bedside Duplex ultrasound in order to measure infrarenal abdominal aortic diameter.
Intermediate/low-SYNTAX score patients	Diagnostic Test: Abdominal aortic Duplex ultrasound; All patients will undergo bedside Duplex ultrasound in order to measure infrarenal abdominal aortic diameter.

Outcome Measures

Primary Outcome Measures

1. Infrarenal abdominal aortic diameter [Baseline]

   Infrarenal abdominal aortic diameter measured by bedside Duplex ultrasound by the principal investigator, Dr. Ozeren-Topcu

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Undergoing coronary artery bypass graft surgery

• Age >18 years

Exclusion Criteria:

• Age <18 years

• Pregnancy

• Breastfeeding

• Emergency surgery

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

• Basaksehir Cam & Sakura Şehir Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

• Bergersen L, Kiernan MS, McFarlane G, Case TD, Ricci MA. Prevalence of abdominal aortic aneurysms in patients undergoing coronary artery bypass. Ann Vasc Surg. 1998 Mar;12(2):101-5.
• Yammine M, Itagaki S, Pawale A, Toyoda N, Reddy RC. SYNTAX score may predict the severity of atherosclerosis of the ascending aorta. J Thorac Dis. 2017 Oct;9(10):3859-3865. doi: 10.21037/jtd.2017.09.17.

• Responsible Party: Kamile Özeren Topçu, Principal Investigator, Basaksehir Cam & Sakura Şehir Hospital
• ClinicalTrials.gov Identifier: NCT05449509
• Other Study ID Numbers: KAEK/2022.02.43
• First Posted: Jul 8, 2022
• Last Update Posted: Jul 8, 2022
• Last Verified: Jul 1, 2022

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Coronary Artery Disease; Aneurysm; Aortic Aneurysm; Aortic Aneurysm, Abdominal

Study Results

No Results Posted as of Jul 8, 2022