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ACCUMBENS: Accumbofrontal Tract Study in 2 Populations of Patients With Anorexia Nervosa and Obsessional Compulsive Disorder and Healthy Volunteer

Sponsor
Poitiers University Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT03496285
Collaborator
(none)
30
Enrollment
1
Location
42.5
Actual Duration (Months)
0.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Restrictive anorexia nervosa and TOCs are psychiatric diseases which shares a common pathophysiological substrate We hypothesize that anorexia patients and patients with OCD have structural and functional changes in the accumbofrontal tract. The main objective of this study will be to compare the structure and the connectivity of this tract in MRI with diffusion sequences (DTI tractography) and resting-state, in 3 distinct populations of anorexic patients, patients with OCD and healthy patients. The role of the accumbo-frontal tract in the cortico-striato-hypothalamo-cortical circuit seems to be established. DTI tractography will allow the measurement of functional anisotropy (FA), a parameter that evaluates the diffusion of water molecules along the white matter fibers, and therefore the potential alteration of the studied tract. Resting state sequences will allow to estimate the BOLD signal and the functionality of the tract.

Condition or Disease Intervention/Treatment Phase
  • Radiation: Multimodal MRI with diffusion sequence for anorexia nervosa patient
  • Radiation: Multimodal MRI with diffusion sequence for obsessional compulsive disorder patient
  • Radiation: Multimodal MRI with diffusion sequence for healthy volunteer
 N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
30 participants
Allocation:
N/A
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Other
Official Title:
Multimodal MRI Study of Accumbofrontal Tract in Anorexia Nervosa and Obessional Compulsive Disorder : Search for Structural and Functional Changes Between Orbito-frontal Cortex and Accumbens Nucleus Subdivisions
Actual Study Start Date :
May 9, 2018
Actual Primary Completion Date :
Nov 24, 2021
Actual Study Completion Date :
Nov 24, 2021

Outcome Measures

Primary Outcome Measures

  1. Fractional Anisotropy (probabilistic tractography) [20 minutes]

    Evaluate the mean functional anisotropy value for fiber bundles connecting the orbito-frontal cortex and the nucleus accumbens

Secondary Outcome Measures

  1. BOLD Signal (resting state) [20 minutes]

    Evaluate the value of the BOLD-signal of the fiber bundles connecting the orbito-frontal cortex and the nucleus accumbens

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 65 Years
Sexes Eligible for Study:
Female
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Female patients

  • Age between 18 and 65 years

  • Subjects free to give their written consent

For anorexia nervosa :

  • Patients meeting the diagnostic criteria for anorexia nervosa according to DSM5 (American Psychiatric Association): low weight (<85% of expected weight for age and height), fear of gaining weight or becoming fat, distortion of body image, and amenorrhea for more than 3 months

  • Treatment with at least one antidepressant and one anxiolytic

For OCD :

  • Patients meeting the diagnostic criteria of OCDs according to DSM5 (American Psychiatric Association) : presence of obsessions and / or compulsions, resulting in clinically significant suffering (loss of at least one hour per day) or impairment at the social, occupational level or in another important area of life. These symptoms are not due to the physiological effects of a substance or a general medical condition and cannot be better explained by the symptoms of another psychiatric disorder.

  • Patients with homogeneous OCD in obsession and compulsion.

  • Normal weight compared to expected weight for age and height

  • Treatment with at least one antidepressant and one anxiolytic

ForHealthy volunteer

•Normal weight compared to expected weight for age and height

Exclusion Criteria:

  • Male

  • Age <18 years or> 65 years

  • Pregnancy

  • Absence of free and informed consent signature

  • Current processing by rTMS

  • Somatic intercurrent pathologies: neurological, cardiological, pneumological, renal, hepatic, endocrine, metabolic disorders ...

  • Mental retardation (WAIS-IV QI <70)

  • Primary Amenorrhea

  • Absolute contraindication or relative to the realization of a magnetic resonance imaging without injection of contrast medium

  • Old or intercurrent psychotic pathology

Contacts and Locations

Locations

Site City State Country Postal Code
1 CH Laborit Poitiers France 86021

Sponsors and Collaborators

  • Poitiers University Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Poitiers University Hospital
ClinicalTrials.gov Identifier:
NCT03496285
Other Study ID Numbers:
  • ACCUMBENS
First Posted:
Apr 12, 2018
Last Update Posted:
Mar 31, 2022
Last Verified:
Mar 1, 2022
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Anorexia
Compulsive Personality Disorder
Anorexia Nervosa

Study Results

No Results Posted as of Mar 31, 2022