The Effect of Propofol or Sevoflurane on Renal Function
Study Details
Study Description
Brief Summary
This study investigates the role of the anesthetic agents propofol and sevoflurane on renal function in otherwise healthy patients undergoing basic back surgery.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 4 |
Detailed Description
Water-sodium homeostasis is central for anyone undergoing surgery, and can therefore affect surgical outcome, level of postoperative care and the length of hospital stay. Too much or too little fluid during surgery can affect the patients negatively. The kidneys play an imperative role in the regulation of water and sodium homeostasis, however there are lack of knowledge in how the anesthesia per se affects renal function. Previous studies have shown that volatile anesthetic agents such as sevoflurane can cause fluid retention. Why this happens is not completely known.
We are now investigating the different affects of sevoflurane and propofol anesthesia on renal function in patients undergoing basic back surgery to elucidate if there is a difference in the risk of developing acute kidney injury.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Sevoflurane Intervention Back surgery and sevoflurane. |
Procedure: Back Surgery
All patients undergo basic back surgery.
Drug: Sevoflurane
Anesthesia on sevoflurane alone.
|
Active Comparator: Propofol Intervention Back surgery and propofol. |
Procedure: Back Surgery
All patients undergo basic back surgery.
Drug: Propofol
Anesthesia on propofol alone.
|
Outcome Measures
Primary Outcome Measures
- Change in urine output [24 hours]
Urine output (ml/min) changes during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.
- Change in serum creatinine levels [24 hours]
Changes in serum creatinine levels during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.
- Change in creatinine clearance [24 hours]
Creatinine clearance changes during anesthesia, in postoperative care and in the ward unit. Changes will be assessed with AKIN RIFLE and by comparison between the different groups.
Secondary Outcome Measures
- Changes in electrolytes [24 hours]
Changes in serum and urinary electrolytes (sodium and potassium) will be measured during anesthesia, in postoperative care and in the ward unit.
- Changes in hormone levels [24 hours]
The hormones angiotensin II, anti diuretic hormone and aldosterone will be measured during anesthesia, in postoperative care and in the ward unit.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Scheduled back surgery
Exclusion Criteria:
-
American Association of Anesthesiology class 1-3
-
American Heart Association class >3
-
BMI >37
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Insulin treated diabetes
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Pregnancy or breast feeding
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Sensistivity/allergy against anesthetic agents
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Inadequate understanding about the study
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Depressed kidney function and/or AKI
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Depressed liver function
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Genetic malignant hyperthermia
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Akademiska sjukhuset, Centraloperation | Uppsala | Sweden | 75185 |
Sponsors and Collaborators
- Uppsala University
- The Swedish Research Council
Investigators
- Principal Investigator: Stephanie Franzén, PhD, Uppsala University, Department of Anesthesiology and Intensive Care
- Study Director: Robert Frithiof, MD PhD, Uppsala University, Department of Anesthesiology and Intensive Care
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ANIMAL-523-2014-2569