Alpha MSH in Ocular Disease
Study Details
Study Description
Brief Summary
The purpose of this study is gain a better understanding of a molecule called alpha melanocyte stimulating hormone (alpha MSH) and its potential role in your retinal disease. Alpha MSH has been shown to have an important role in the regulation of ocular immunity in animal models of inflammatory retinal diseases and retinal dystrophies, and there may be a protective effect of alpha MSH. By studying the levels of alpha MSH in your eye we may better understand its role in advanced dry macular degeneration. By studying the levels of this molecule we hope to better understand if it may be a good target for future treatment.
Condition or Disease | Intervention/Treatment | Phase |
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N/A |
Detailed Description
A small amount (0.1 mL) of aqueous humor would be removed from the study eye in the clinic setting. This sample will be processed and then sent off for measurement of alpha MSH levels.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Other: Advanced Dry macular degeneration
|
Device: Alpha MSH assay
Assay to detect levels of alpha MSH in intraocular fluid.
|
Outcome Measures
Primary Outcome Measures
- Level of alpha melanocyte stimulating hormone as measured by enzyme-linked immunosorbent assay [2 hours]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
60 years or older
-
diagnosis of advanced dry macular degeneration with foveal geographic atrophy
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limited vision or blindness (20/100 or worse) in that eye
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pseudophakia (prior cataract surgery in that eye)
Exclusion Criteria:
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Duke University Eye Center | Durham | North Carolina | United States | 27710 |
Sponsors and Collaborators
- Duke University
Investigators
- Principal Investigator: Sharon Fekrat, MD, Duke Eye Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Pro00086021