Study of YH004 (4-1BB Agonist Antibody) in Advanced Solid Tumors And Relapsed Or Refractory Non-Hodgkin Lymphoma

Sponsor
Eucure (Beijing) Biopharma Co., Ltd (Industry)
Overall Status
Not yet recruiting
CT.gov ID
NCT05564806
Collaborator
(none)
38
2
1
38
19
0.5

Study Details

Study Description

Brief Summary

This is an multicenter, open-label, dose-escalation study of the study drug YH004 . The study is designed to determine the safety, tolerability, maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of YH004 in subjects with advanced solid tumors and relapsed or refractory Non-Hodgkin lymphoma.

Condition or Disease Intervention/Treatment Phase
Phase 1

Study Design

Study Type:
Interventional
Anticipated Enrollment :
38 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Intervention Model Description:
Clinical trials with a single armClinical trials with a single arm
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Multicenter, Open-Label, Phase I Dose Escalation Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of YH004 In Subjects With Advanced Solid Tumors And Relapsed Or Refractory Non-Hodgkin Lymphoma
Anticipated Study Start Date :
Dec 9, 2022
Anticipated Primary Completion Date :
Oct 24, 2025
Anticipated Study Completion Date :
Feb 7, 2026

Arms and Interventions

Arm Intervention/Treatment
Experimental: Intervention/treatment

All subject will receive YH004 intravenously as single agent every three weeks (Q3W), until intolerable toxicity, disease progression, withdrawal of consent, or Investigator decision, whichever comes first.

Drug: YH004
All subject will receive YH004 intravenously as single agent every three weeks (Q3W), until intolerable toxicity, disease progression, withdrawal of consent, or Investigator decision, whichever comes first.

Outcome Measures

Primary Outcome Measures

  1. Adverse events (AEs) [up to 1 year after the last dosing]

    The safety profile of YH004 will be assessed by monitoring the adverse events (AE) per NCI CTCAE v5.0.

  2. Maximum tolerated dose (MTD) and/or Recommended phase 2 dose (RP2D) [up to 1 year after the last dosing]

    The MTD and/or RP2D will be determined based on the data of safety and tolerability.

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  1. Willing and able to provide signed and dated informed consent prior to any study related procedures and willing and able to comply with all study procedures.

  2. Patients with histologically or cytologically confirmed advanced solid tumor or relapsed or refractory Non-Hodgkin Lymphoma (including but not limited to inert and transformed type, patients with inert lymphoma must undergo systematic treatment at the time of screening), which has progressed after treatment with standard therapies or intolerant of standard therapies or have no standard of care.

  3. Subject must have at least one measurable lesion by RECIST 1.1 or per Cheson criteria (Lugano 2014).

  4. Subjects must be 18 years to 80 years of age at the time of screening.

  5. Subjects must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

  6. Have life expectancy of at least 12 weeks based on investigator's judgement.

  7. Sufficient organ and bone marrow functions before screening or administration.

  8. Women of reproductive potential must have negative serum beta human chorionic gonadotropin (β -HCG) pregnancy test at the time of screening.

  9. Women of reproductive potential who are sexually active must consistently use highly effective contraception/birth control (less than 1% per year) between signing of the informed consent and 90 days after the last administration of the study drug.

Exclusion Criteria:
  1. Previous exposure to an anti-CD137 (e.g., utomilumab, urelumab) antibodies.

  2. Subjects must not have another active invasive malignancy within 2 years or currently.

  3. Subjects have received any anticancer therapy or another investigational agent within the longer of 4 weeks or 5 half-lives before the first dose of the study drug.

  4. Continuance of toxicities due to prior anti-tumor therapy that have not recovered to ≤ Grade 1 per CTCAE 5.0.

  5. Subjects who have major operations within 4 weeks before the first dose of the study drug, or minor surgery within 2 weeks prior to the first dose.

  6. Subjects have received any radiotherapy within the longer of 4 weeks before the first dose of the study drug.

  7. Subjects with primary CNS malignancy or symptomatic CNS metastasis.

  8. Subjects with a history of ≥ Grade 3 immune-related adverse events resulted from previous immunotherapy or treatment discontinuation due to previous immunotherapy.

  9. Subjects must not receive concurrent or prior use of an immunosuppressive agent within 4 weeks of the first dose of study drug.

  10. Subjects must not receive any other investigational drug or participated in other clinical studies within 4 weeks before the first dose of study drug.

  11. Subjects must not have received a live vaccine or attenuated live vaccine within 4 weeks before the first dose of study drug.

  12. Known allergies to the active ingredient or excipients of the test drug, or history of severe allergic reaction (≥ grade 3) to any other monoclonal antibody or intravenous therapeutic protein preparation drug.

  13. History of interstitial lung disease or noninfectious pneumonia requiring corticosteroid treatment.

  14. More than moderate amount of uncontrollable pleural, abdominal or pericardial effusion requiring repeated drainage or with obvious symptoms.

  15. Subjects must not have an active autoimmune disease, a history of autoimmune disease requiring systemic therapy, or a history of autoimmune disease within 2 years of the first dose of study drug.

  16. Clinically uncontrolled illness, including but not limited to severe diabetes, uncontrolled hypertension, serious endocrine disorders or other serious diseases requiring systemic treatment such as severe abnormal thyroid function.

  17. Subjects must not have a history or persistent active virus or tuberculosis infection. Including but not limited to: human immunodeficiency virus (HIV), syphilis, hepatitis C, hepatitis B or active COVID-19 infection; previous or current active pulmonary tuberculosis and other active infectious diseases.

  18. Severe infections requiring intravenous administration within 7 days before the first dose of study drug.

  19. Severe cerebro-cardiovascular disease within 6 months of the first dose of study drug, such as cerebrovascular rupture, stroke, myocardial infarction, unstable angina pectoris, congestive heart failure (NYHA grade ≥ II), valvular disease with significant clinical significance, and serious out of control arrhythmia requiring drug treatment (pulmonary hypertension or left ventricular ejection fraction (LVEF) ≤ 50% during screening period).

  20. QTc > 480 ms at baseline, corrected for heart rate using Frederica's formula.

  21. Subjects must not have a history of allogeneic bone marrow transplantation or organ transplantation.

  22. Any known mental illness or disorder, substance abuse history, drug abuse history or alcohol dependence history that would preclude subject from participation.

  23. Females who are lactating, except for whom agreed to stop lactating during the trial.

  24. Any condition that the investigator believes may not be appropriate for participating the study.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Henan Cancer Hospital Zhengzhou Henan China 450008
2 Sir Run Run Shaw Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China 310020

Sponsors and Collaborators

  • Eucure (Beijing) Biopharma Co., Ltd

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Eucure (Beijing) Biopharma Co., Ltd
ClinicalTrials.gov Identifier:
NCT05564806
Other Study ID Numbers:
  • YH004003
First Posted:
Oct 4, 2022
Last Update Posted:
Oct 24, 2022
Last Verified:
Oct 1, 2022
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Oct 24, 2022