The Effect of Resistance Exercise on Inflammation in Young and Older Adults

Sponsor

National Taiwan Normal University (Other)

Overall Status

Recruiting

CT.gov ID

NCT05042167

Collaborator

(none)

Enrollment

Location

Arms

Anticipated Duration (Months)

2.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

Condition or Disease	Intervention/Treatment	Phase
Aging Inflammatory Response	Other: Resistance exercise	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

40 participants

Allocation:

Randomized

Intervention Model:

Crossover Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

The Acute Effect of High-load Resistance Exercise on Inflammation in Young and Older Adults

Actual Study Start Date :

Oct 1, 2021

Anticipated Primary Completion Date :

Jul 31, 2022

Anticipated Study Completion Date :

Dec 31, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: High-load resistance exercise Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.	Other: Resistance exercise 4 total resistance exercises that target all major muscle groups.
No Intervention: Sedentary control Subjects in control trial stayed sedentary during the period.

Arm

Intervention/Treatment

Experimental: High-load resistance exercise

Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.

Other: Resistance exercise

4 total resistance exercises that target all major muscle groups.

No Intervention: Sedentary control

Subjects in control trial stayed sedentary during the period.

Outcome Measures

Primary Outcome Measures

Changes in biomarkers of inflammation [24-hour during each study intervention]
Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.

Secondary Outcome Measures

Changes in glucose [24-hour during each study intervention]
glucose in mg/dL
Changes in metabolic parameters [24-hour during each study intervention]
Metabolic parameters will be measured such as TC in mg/dL, TG in mg/dL, and HDL in mg/dL.
Changes in biomarkers of muscle damage [24-hour during each study intervention]
Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.
Changes in molecular markers in peripheral blood mononuclear cells (PBMC) [24-hour during each study intervention]
Molecular markers in PBMC will be measured such as STAT3 in arbitrary units, IKK in arbitrary units, IkB in arbitrary units, p65 in arbitrary units, SOCS3 in arbitrary units, AMPK in arbitrary units, and SIRT1 in arbitrary units.
Changes in complete blood count (CBC) [24-hour during each study intervention]
The white blood cell count and the count of each white blood cell type will be measured.
Borgs Ratings of Perceived Exertion (RPE) [1-hour during each exercise intervention]
Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 80 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Age: 20-80
Healthy male
Without experience of resistance training

Exclusion Criteria:

No acute or chronic musculoskeletal symptoms
Smoking
Alcohol or drug abuse
Fail to conduct resistance exercise

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	National Taiwan Normal University	Taipei		Taiwan	162

Sponsors and Collaborators

National Taiwan Normal University

Investigators

Principal Investigator: Hung-Wen Liu, Ph.D., National Taiwan Normal University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

National Taiwan Normal University

ClinicalTrials.gov Identifier:

NCT05042167

Other Study ID Numbers:

202012HM020

First Posted:

Sep 13, 2021

Last Update Posted:

Nov 12, 2021

Last Verified:

Nov 1, 2021

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Inflammation

Study Results

No Results Posted as of Nov 12, 2021