Air Pollution and Health of COPD Patients
Study Details
Study Description
Brief Summary
This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
This panel study was conducted in a group of stable patients with COPD in Beijing, China. The health measurements including lung function, blood pressure and airway inflammation were conducted, and morning urine, exhaled breath condensate, saliva and venous blood were collected at the time of enrollment and at 3, 6 and 9 months after enrollment. Individual exposures to fine particulate matter (PM2.5), black carbon (BC), ozone (O3) and nitrogen dioxide (NO2) were performed for 24 hours at each follow-up. And the daily concentrations of air pollutants were collected from the Beijing Air Quality Real-time Publishing Platform and meteorological data were collected from the National Meteorological Information Center. The linear mixed effects model was used to analyze the association between air pollution and cardiopulmonary health in patients with COPD.
Study Design
Outcome Measures
Primary Outcome Measures
- Lung function [Nine months]
Lung function test was conducted.
Secondary Outcome Measures
- COPD Assessment Test scores [Nine months]
COPD Assessment Test (CAT) scores were used to assess quality of life in COPD patients on a scale of 0 to 40, with higher scores associated with poorer outcomes.
- Modified British Medical Research Council (mMRC) Questionnaire score [Nine months]
Modified British Medical Research Council (mMRC) Questionnaire score was used to assess the severity of dyspnea on a scale of 0 to 4, with a higher score indicating a worse outcome.
- ST. George's Respiratory Questionnaire scores [Nine months]
ST. George's Respiratory Questionnaire (SGRQ) scores were used to assess quality of life in patients with COPD on a scale of 0 to 100, with higher scores indicating poorer outcomes.
- Blood pressure [Nine months]
Systolic and diastolic blood pressure of participants were measured at least three times by a trained technician.
- Respiratory inflammation [Nine months]
Fractional exhaled nitric oxide (FeNO) test was conducted.
- Airway and systemic oxidative stress levels [Nine months]
Exhaled Breath Condensate (EBC) and urine samples were collected for oxidative stress analysis.
- Systemic inflammation [Nine months]
Venous blood was collected for determination of systemic inflammatory biomarkers.
Eligibility Criteria
Criteria
Inclusion Criteria:
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doctor-diagnosed stable COPD patients
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aged 40 to 80 years
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lived in Beijing for over one year before being recruited
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Agree to participate and sign the informed consent form.
Exclusion Criteria:
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Patients with a history of acute exacerbation in the last 1 month
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Patients with other respiratory diseases such as bronchiectasis and asthma.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Peking University | Beijing | China | 100191 |
Sponsors and Collaborators
- Peking University
Investigators
- Principal Investigator: Furong Deng, Doctor, Peking University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- IRB00001052-21085