CASE: Combating Alzheimer's Through Sleep and Exercise
Study Details
Study Description
Brief Summary
Alzheimer's/dementia is an increasingly critical public health risk, with over 50 million Americans at risk for the disease. To stem the burden of Alzheimer's disease, prophylactic and protective strategies such as physical activity and sleep have been recommended to reduce the risk of cognitive decline and Alzheimer's/dementia. Previous research indicate that exercise improves cognition and lowers dementia risk and may be a promising intervention to address dementia risk in the general population. Sleep, specifically slow wave sleep, may reduce dementia risk, based on previous work showing that greater levels of slow wave sleep was related to higher cognition. However, little is known about the independent and combined effects exercise and sleep have on cognition. The proposed study therefore aims to investigate the independent and combined effects exercise (aerobic and stretching) and sleep have on cognition and what heart health, sleep and stress correlates confound this association.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Sleep Only
|
Other: DREEM 2 Headband
Participants will wear the DREEM 2 headband for 3 months for a minimum of 4 out of 7 nights per week and will participate in its digital therapeutic CBT-I intervention (entails brain stimulation to improve slow wave sleep and sleep hygiene counseling tips to improve sleep behaviors).
|
Active Comparator: Exercise Only
|
Other: Fitbit
Participants will partake in a guided exercise routine (30-minute mild circuit training session while VO2 is estimated from a Fitbit device twice per week for 3 months).
|
Active Comparator: Exercise + Sleep
|
Other: DREEM 2 Headband
Participants will wear the DREEM 2 headband for 3 months for a minimum of 4 out of 7 nights per week and will participate in its digital therapeutic CBT-I intervention (entails brain stimulation to improve slow wave sleep and sleep hygiene counseling tips to improve sleep behaviors).
Other: Fitbit
Participants will partake in a guided exercise routine (30-minute mild circuit training session while VO2 is estimated from a Fitbit device twice per week for 3 months).
|
Outcome Measures
Primary Outcome Measures
- Total Cholesterol Level [Week 6]
Measured from blood sample
- Total Cholesterol Level [Week 12]
Measured from blood sample
- High-Density Lipoprotein (HDL) Level [Week 6]
Measured from blood sample
- High-Density Lipoprotein (HDL) Level [Week 12]
Measured from blood sample
- Calculated Low-Density Lipoprotein (LDL) Level [Week 6]
Measured from blood sample
- Calculated Low-Density Lipoprotein (LDL) Level [Week 12]
Measured from blood sample
- Triglycerides Level [Week 6]
Measured from blood sample
- Triglycerides Level [Week 12]
Measured from blood sample
- high-sensitivity C-reactive protein (hs-CRP) Level [Week 6]
Measured from blood sample
- high-sensitivity C-reactive protein (hs-CRP) Level [Week 12]
Measured from blood sample
- HbA1c [Week 6]
Measured from blood sample
- HbA1c [Week 12]
Measured from blood sample
- Heart Rate [Week 6]
Measured from Fitbit
- Heart Rate [Week 12]
Measured from Fitbit
- Blood Pressure [Week 6]
Measured from Fitbit
- Blood Pressure [Week 12]
Measured from Fitbit
- Total Sleep Duration [Week 6]
Measured from DREEM 2
- Total Sleep Duration [Week 12]
Measured from DREEM 2
- Slow Wave Sleep Duration [Week 6]
Measured from DREEM 2
- Slow Wave Sleep Duration [Week 12]
Measured from DREEM 2
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Age 45 years and older
-
Able to perform mild exercise
-
Able to wear DREEM 2 Headband
-
Able to wear a Fitbit wrist watch
-
Able to perform the Everlywell biomarker procedure
-
Able to Understand and Speak English
-
Able to operate a digital device like mobile phone, iPad, or computer
-
Self-reported history of problems with cognitive impairment: memory, concentration, and processing information
-
Only participants cognitively able and willing to provide consent will be included.
Exclusion Criteria:
-
Under 45 years old
-
Prohibited from or unable to perform mild exercise
-
Unable to wear wrist watch or headband devices, or unable to supply pinprick blood sample for any reason
-
Unable to speak or understand English
-
Unable to use mobile device/smartphone technology
-
Unable or unwilling to consent for any reason.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | NYU Langone Health | New York | New York | United States | 10016 |
Sponsors and Collaborators
- University of Miami
Investigators
- Principal Investigator: Azizi A Seixas, PhD, NYU Langone Health
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20-01023