ALPS: Time-in-bed Restriction in Older Adults With Sleep Difficulties With and Without Risk for Alzheimer's Disease

Sponsor
University of Pittsburgh (Other)
Overall Status
Recruiting
CT.gov ID
NCT05138848
Collaborator
National Institute on Aging (NIA) (NIH)
116
1
2
52.9
2.2

Study Details

Study Description

Brief Summary

Dementia caused by Alzheimer's disease affects approximately 5.6 million adults over age 65, with costs expected to rise from $307 billion to $1.5 trillion over the next 30 years. Behavioral interventions have shown promise for mitigating neurodegeneration and cognitive impairments. Sleep is a modifiable health behavior that is critical for cognition and deteriorates with advancing age and Alzheimer's disease. Thus, it is a priority to examine whether improving sleep modifies Alzheimer's disease pathophysiology and cognitive function. Extant research suggests that deeper, more consolidated sleep is positively associated with memory and executive functions and networks that underlie these processes. Preliminary studies confirm that time-in-bed restriction interventions increase sleep efficiency and non-rapid eye movement slow-wave activity (SWA) and suggest that increases in SWA are associated with improved cognitive function. SWA reflects synaptic downscaling predominantly among prefrontal connections. Downscaling of prefrontal connections with the hippocampus during sleep may help to preserve the long-range connections that support memory and cognitive function. In pre-clinical Alzheimer's disease, hyperactivation of the hippocampus is thought to be excitotoxic and is shown to leave neurons vulnerable to further amyloid deposition. Synaptic downscaling through SWA may mitigate the progression of Alzheimer's disease through these pathways. The proposed study will behaviorally increase sleep depth (SWA) through four weeks of time-in-bed restriction in older adults characterized on amyloid deposition and multiple factors associated with Alzheimer's disease risk. This study will examine whether behaviorally enhanced SWA reduces hippocampal hyperactivation, leading to improved task-related prefrontal-hippocampal connectivity, plasma amyloid levels, and cognitive function. This research addresses whether a simple, feasible, and scalable behavioral sleep intervention improves functional neuroimaging indices of excitotoxicity, Alzheimer's pathophysiology, and cognitive performance.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Time in Bed Restriction
  • Behavioral: Sleep Schedule
N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
116 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Intervention Model Description:
Participants will be randomized to one of two intervention groups. The active group will limit their time in bed for 4 weeks by following a consistent sleep schedule with 85% time in bed compared to their baseline time in bed. The control group will not limit their time in bed, but will also follow a consistent sleep schedule based on their baseline time in bed.Participants will be randomized to one of two intervention groups. The active group will limit their time in bed for 4 weeks by following a consistent sleep schedule with 85% time in bed compared to their baseline time in bed. The control group will not limit their time in bed, but will also follow a consistent sleep schedule based on their baseline time in bed.
Masking:
Single (Outcomes Assessor)
Masking Description:
Data collection and data reduction will be performed by sleep technicians and staff who are blind to study hypotheses and the randomization assignment.
Primary Purpose:
Treatment
Official Title:
Slow-wave Sleep Enhancement in Those at Risk for Alzheimer's Disease: Links With Memory, Excitotoxicity, and Plasma A-beta
Actual Study Start Date :
Jan 3, 2022
Anticipated Primary Completion Date :
May 31, 2026
Anticipated Study Completion Date :
May 31, 2026

Arms and Interventions

Arm Intervention/Treatment
Experimental: Time in Bed Restriction

Time in Bed (TIB) restriction of 85% of habitual TIB.

Behavioral: Time in Bed Restriction
Participants will undergo a 4-week sleep intervention that includes specified in- and out-of-bed times as well as a restriction to their habitual time in bed (average sleep opportunity including naps). This will be truncated equally at the beginning and end of the night.

Behavioral: Sleep Schedule
Participants will undergo a 4-week sleep intervention that includes specified in- and out-of-bed times based on their habitual sleep times.

Active Comparator: Control

No change of time in bed, but prescribed sleep schedule based on observed average sleep and wake times.

Behavioral: Sleep Schedule
Participants will undergo a 4-week sleep intervention that includes specified in- and out-of-bed times based on their habitual sleep times.

Outcome Measures

Primary Outcome Measures

  1. Mean change in slow-oscillation activity assessed with electroencephalography [Baseline and 4 weeks]

    Slow oscillation electroencephalographic power (0.5-1 Hz) during non-rapid eye movement sleep

  2. Mean change in Hippocampal Activation [Baseline and 4 weeks]

    Change in mean percent signal change of the hippocampus during memory encoding assessed with functional magnetic resonance imaging

  3. Medial prefrontal-Hippocampal Connectivity [Baseline and 4 weeks]

    Change in the correlation between medial prefrontal activity and hippocampal activity during memory encoding assessed with functional magnetic resonance imaging during awake rest

  4. Change in mean Plasma amyloid-beta 1-42 [Baseline and 4 weeks]

    Change in mean amyloid-beta detected in the plasma in the morning

  5. Overnight memory retention on the AB paired associate task, preclinical Alzheimer's cognitive composite score [Baseline and 4 weeks]

    Mean change in percent correct memory and cognitive performance and cognitive composite score

  6. Amyloid positivity status [Baseline]

    Amyloid positivity above or below established cutoffs assessed with Pittsburgh Compound B positron emission tomography

Secondary Outcome Measures

  1. Mean change in delta activity during sleep [Baseline and 4 weeks]

    Mean change in delta electroencephalographic power (1-4 Hz) during non-rapid eye movement sleep

  2. Mean change in Sleep Efficiency [Baseline and 4 weeks]

    Mean change in the proportion of time in bed spent sleeping

  3. Mean percent signal change in medial prefrontal activation [Baseline and 4 weeks]

    Mean percent signal change in medial prefrontal cortex activation during a memory encoding task

  4. Mean change in medial temporal-Hippocampal Connectivity [Baseline and 4 weeks]

    Mean change in

  5. mean change in plasma amyloid-beta composite score [Baseline and 4 weeks]

    mean change in amyloid-beta levels in plasma

  6. Mean change in response time on executive function tasks [Baseline and 4 weeks]

    Computerized executive function task mean response time in milliseconds

  7. Mean change in accuracy on executive function tasks [Baseline and 4 weeks]

    Computerized executive function task mean percent accuracy

  8. Apolipoprotein (ApoE) e4 allele carrier status [Baseline]

    presence of the e4 apolipoprotein based on genetic testing

  9. Cognitive status based on neuropsychological adjudication [Baseline]

    Cognitive status of healthy control or mild cognitive impairment

  10. Clinical insomnia status [Baseline]

    Diagnosis of insomnia based on clinical cutoffs with self-reported sleep questionnaires

Eligibility Criteria

Criteria

Ages Eligible for Study:
65 Years to 85 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Age 65-85.

  • Self-report mean sleep efficiency (the time in bed spent asleep within the time of lights out to final awakening) < 90% based on diary and actigraphy estimates and wake time after sleep onset > 20 minutes based on diary and actigraphy estimates.

  • Self-reported normal or corrected-to-normal visual and auditory acuity.

Exclusion Criteria:
  • Shift work involving night shift or regular work after 9pm.

  • Presence of a chronic condition that significantly affects sleep.

  • Severe psychiatric condition including major depressive disorder, panic disorder, substance use disorders, and alcohol abuse/dependence within the past 6 months, or a lifetime history of a psychotic disorder or bipolar disorder, based on initial online/phone self-report diagnoses, and subsequently based on the M.I.N.I International Neuropsychiatric Interview.

  • Current use of medications affecting sleep such as antidepressants, antipsychotic medications, anticonvulsants, and steroids.

  • Current use of sedating drugs used at bedtime.

  • Consumption of > 14 alcohol drinks per week or > 6 drinks at a single sitting.

  • Consumption of > 3 caffeine drinks per day.

  • Prior diagnosis of a Central nervous system (CNS) disease, such as multiple sclerosis, stroke, Parkinson's disease, Alzheimer's disease, seizure disorder, delirium or dementia, a loss of consciousness > 24 hours, or traumatic brain injury as identified by the Cumulative Illness Rating Scale for Geriatrics (CIRS). Participants who are diagnosed with Alzheimer's disease based on neuropsychological testing will be excluded.

  • Sleep efficiency > 90% and wake time after sleep onset < 20 minutes consistent with the rationale of the inclusion criteria described above.

  • Apnea/hypopnea index greater than 15 as determined by one night of Apnea Link Plus screening.

  • Metal in the body. Rationale: Due to the nature of magnetic resonance imaging (MRI), participants cannot have any metal implants in their bodies, cannot have worked in a metal shop or been exposed to metal fragments during combat. Metal dental work (e.g. fillings crowns) may be allowed if compatible with the MRI scanner.

  • Claustrophobia. Rationale: Could prevent the participant from completing the MRI scans.

  • Severe obesity. BMI > 40. Rationale: Could prevent the participant from completing the MRI scan.

  • Near-miss or prior automobile accident "due to sleepiness" within the past 12 months. Rationale: reduces the risk of sleepiness-related accidents.

  • Employed as a commercial driver during the study (for example, bus drivers, train engineers, airplane pilots). Rationale: reduces the risk of sleepiness-related accidents.

  • A score below 23 on the Telephone Interview for Cognitive Status. Rationale: This cut-off has been demonstrated to differentiate well between individuals with mild cognitive impairment from individuals with dementia who would have decision making impairments (Seo et al. 2011, Archives of Gerontology and Geriatrics). This ensures that decision making abilities are intact.

Contacts and Locations

Locations

Site City State Country Postal Code
1 UPMC Western Psychiatric Hospital Pittsburgh Pennsylvania United States 15213

Sponsors and Collaborators

  • University of Pittsburgh
  • National Institute on Aging (NIA)

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Kristine Wilckens, Assistant Professor, University of Pittsburgh
ClinicalTrials.gov Identifier:
NCT05138848
Other Study ID Numbers:
  • STUDY20110278
  • R01AG068001
First Posted:
Dec 1, 2021
Last Update Posted:
Mar 8, 2022
Last Verified:
Mar 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Product Manufactured in and Exported from the U.S.:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Mar 8, 2022