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EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT04444921
Collaborator
(none)
205
Enrollment
542
Locations
2
Arms
29.5
Anticipated Duration (Months)
0.4
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase 3 trial compares the addition of nivolumab to chemotherapy (carboplatin and paclitaxel) versus usual treatment (chemotherapy alone) for the treatment of anal cancer that has spread to other places in the body (metastatic). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving nivolumab together with carboplatin and paclitaxel may help doctors find out if the treatment is better or the same as the usual approach.

Condition or Disease Intervention/Treatment Phase
Phase 3

Detailed Description

PRIMARY OBJECTIVE:
  1. To demonstrate that anti-PD-1 therapy in combination with carboplatin/weekly paclitaxel results in improved progression-free survival (PFS) versus systemic chemotherapy alone.
SECONDARY OBJECTIVES:

  1. To demonstrate that anti-PD-1 therapy in combination with carboplatin/weekly paclitaxel results in improved overall survival (OS) versus systemic chemotherapy alone.

  2. To demonstrate that anti-PD-1 therapy in combination with carboplatin/weekly paclitaxel results in improved objective response using Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 versus systemic chemotherapy alone.

  3. To evaluate toxicity profiles of the two regimens.

OUTLINE: Patients are randomized to 1 of 2 arms. Randomization will be 2:1 favoring the experimental regimen, Arm B.

ARM A: Patients receive paclitaxel intravenously (IV) on days 1, 8, and 15 of each cycle, and carboplatin IV on day 1 of each cycle. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive nivolumab IV over 30 minutes on days 1 and 15 of cycle 1 and then on day 1 only of subsequent cycles, paclitaxel IV on days 1, 8, and 15 of each cycle, and carboplatin on day 1 of each cycle. Treatment repeats every 28 days for up to 6 cycles for carboplatin and paclitaxel, and up to 2 years for nivolumab in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 1 month, then every 3 months for 2 years.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
205 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Randomized Phase III Study of Immune Checkpoint Inhibition With Chemotherapy in Treatment-Na�ve Metastatic Anal Cancer Patients
Actual Study Start Date :
Oct 15, 2020
Anticipated Primary Completion Date :
Mar 31, 2023
Anticipated Study Completion Date :
Mar 31, 2023

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Arm A (carboplatin, paclitaxel)

Patients receive paclitaxel IV on days 1, 8, and 15 of each cycle, and carboplatin IV on day 1 of each cycle. Treatment repeats every 28 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.

Drug: Carboplatin
Given IV
Other Names:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carboplatinum
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatinum
  • Paraplatin
  • Paraplatin AQ
  • Paraplatine
  • Platinwas
  • Ribocarbo

    • Drug: Paclitaxel
    Given IV
    Other Names:
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol
  • Taxol Konzentrat

    		•
    Experimental: Arm B (carboplatin, paclitaxel, nivolumab)

    Patients receive nivolumab IV over 30 minutes on days 1 and 15 of cycle 1 and then on day 1 only of subsequent cycles, paclitaxel IV on days 1, 8, and 15 of each cycle, and carboplatin on day 1 of each cycle. Treatment repeats every 28 days for up to 6 cycles for carboplatin and paclitaxel, and up to 2 years for nivolumab in the absence of disease progression or unacceptable toxicity.

    Drug: Carboplatin
    Given IV
    Other Names:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carboplatinum
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatinum
  • Paraplatin
  • Paraplatin AQ
  • Paraplatine
  • Platinwas
  • Ribocarbo

    • Biological: Nivolumab
    Given IV
    Other Names:
  • BMS-936558
  • CMAB819
  • MDX-1106
  • NIVO
  • Nivolumab Biosimilar CMAB819
  • ONO-4538
  • Opdivo

    • Drug: Paclitaxel
    Given IV
    Other Names:
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol
  • Taxol Konzentrat

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Progression-free survival [Up to 2 years]

      Defined as the first of progressive disease or death due to any cause. Analyzed using a stratified two-sided overall 0.05 level log-rank test. Will utilize standard Eastern Cooperative Oncology Group -American College of Radiology Imaging Network interim monitoring for efficacy evaluation.

    Secondary Outcome Measures

    1. Objective response rate (ORR) [Up to 2 years]

      ORR is the ratio of the number of patients with a complete response or partial response, as defined by Response Evaluation Criteria in Solid Tumors version 1.1, to the total number of treated patients.

    2. Overall survival [Time between treatment randomization and death by any cause, assessed up to 2 years]

      Evaluated by a stratified log-rank test, and using a two-sided 0.05 level Cochran Mantel-Haenzel.

    3. Incidence of adverse events [Up to 2 years]

      Analyses of toxicity will be via frequency tabulations and percentages by worst degree of toxicity and comparisons will be done via chi-square or Fisher's exact tests as appropriate.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Patient must have inoperable, recurrent, or metastatic disease not amenable to curative therapy

    • Patient must have histological or cytological confirmation of anal squamous cell carcinoma (includes basaloid and cloacogenic lesions) from the primary tumor or a newly diagnosed recurrent/metastatic lesion

    • Patient must be >= 18 years of age

    • Patient must have Eastern Cooperative Oncology Group (ECOG) performance status =< 0-1

    • Patients must have measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria version 1.1 and based on radiologic assessment performed < 4 weeks prior to randomization

    • Patient receiving palliative (limited-field) radiation therapy is allowed, as long as the lesion treated for palliation is not a target lesion and is > 7 days from completion from palliative radiation

    • Patients with brain metastasis are eligible if patient is asymptomatic and if treatment ended > 3 months prior to randomization. Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression within 4 weeks prior to randomization

    • Absolute neutrophil count >= 1,500/mcL (obtained < 14 days prior to randomization)

    • Platelets >= 100,000/mcL (obtained < 14 days prior to randomization)

    • Hemoglobin (Hb) >= 9 g/dL for males and >= 9 g/dL for females (obtained < 14 days prior to randomization)

    • Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (obtained < 14 days prior to randomization)

    • Aspartate transaminase (AST)(serum glutamic-oxaloacetic transaminase [SGOT]) /alanine transferase (ALT)(serum glutamate pyruvate transaminase [SGPT]) =< 5 x institutional ULN (obtained < 14 days prior to randomization)

    • Creatinine =< 1.5 x institutional ULN OR creatinine clearance (CrCl) >= 50 mL/min (if using the Cockcroft-Gault formula) (obtained < 14 days prior to randomization)

    • Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy (ART) with CD4 count >= 200 or have a CD4 count < 200 but an undetectable viral load are eligible

    • All HIV+ patients should be under the care of an infectious diseases specialist. If a relationship with an infectious diseases specialist is not established, an infectious disease specialist should be consulted. Records of all viral counts and peripheral T-cell counts should be documented in order to follow these values over the course of treatment

    • All patients must be willing to undergo testing for HIV testing if not tested within the past 12 months

    • For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable or on suppressive therapy (if indicated)

    • Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load

    • Patients with known history or current symptoms of cardiac disease, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better. Patients with a history of congestive heart failure (CHF) or who are at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs must be willing to undergo evaluation of cardiac function including electrocardiogram (EKG) and echocardiogram (ECHO) as clinically indicated

    • Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible

    • Patients must agree to not receive live vaccines while on this study

    Exclusion Criteria:

    • Women must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. All females of childbearing potential must have a blood test or urine study with a minimum sensitivity of 25 IU/L or equivalent units of Bacille Calmette-Guerin (BCG), within 14 days prior to randomization to rule out pregnancy. A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).

    • Women of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or to abstain from sexual intercourse for at least one week prior to the start of treatment, and continue for 5 months after the last dose of protocol treatment for women of childbearing potential and 7 months after the last dose of protocol treatment for males who are sexually active with women of childbearing potential (WOCBP)

    • Patient must not have had previous use of systemic chemotherapy or other investigational drugs for the treatment of inoperable recurrent or metastatic anal cancer (previous use of radiotherapy or chemoradiotherapy in this setting is not an exclusion criterion if: 1) non-irradiated target tumor lesions are present at randomization for the purpose of tumor response assessment or 2) in the absence of non-irradiated target tumor lesions, progression of the irradiated tumor lesions according to the RECIST criteria version 1.1 is documented)

    • Patient must not have current or recent (within 30 days prior to randomization) treatment with another investigational drug or participation in another investigational study

    • Patient must not have had prior immunotherapy

    • Patient must not have a history of known hypersensitivity reaction to any platinum or taxane-based chemotherapy or monoclonal antibody

    • Patient must not have active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including chronic prolonged systemic corticosteroids (defined as corticosteroid use of duration one month or greater). These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or anti-phospholipid syndrome. Patients with any of these are ineligible because of the risk of recurrence or exacerbation of autoimmune disease

    • Patient must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of randomization. Inhaled or topical steroids and adrenal replacement doses < 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Patients are permitted to use topical, ocular, intra-articular, intranasal, and inhalational corticosteroids (with minimal systemic absorption). Physiologic replacement doses of systemic corticosteroids are permitted, even if < 10 mg/day prednisone equivalents. A brief course of corticosteroids for prophylaxis (e.g., contrast dye allergy) or for treatment of non-autoimmune conditions (e.g., delayed-type hypersensitivity reaction caused by contact allergen) is permitted

    • Patient must not have had major surgery performed =< 28 days prior to randomization

    • Patient must not have a history of interstitial lung disease (e.g., pneumonitis or pulmonary fibrosis) or evidence of interstitial lung disease on baseline chest computed tomography (CT) scan

    • Patient must not have a serious active infection requiring IV antibiotics at time of randomization

    • Patient must not have other primary malignancy within the last 3 years, except for adequately treated carcinoma in situ of the cervix or squamous carcinoma of the skin, or adequately controlled limited basal cell skin cancer, or any other cancer from which the patient has been disease-free for at least 3 years

    • Patient must not have known peripheral neuropathy > grade 1 at the time of randomization (absence of deep tendon reflexes as the sole neurological abnormality does not render the patient ineligible)

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Anchorage Radiation Therapy Center Anchorage Alaska United States 99504
    3 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    4 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    5 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    6 Anchorage Oncology Centre Anchorage Alaska United States 99508
    7 Katmai Oncology Group Anchorage Alaska United States 99508
    8 Providence Alaska Medical Center Anchorage Alaska United States 99508
    9 Kingman Regional Medical Center Kingman Arizona United States 86401
    10 Cancer Center at Saint Joseph's Phoenix Arizona United States 85004
    11 Mercy Hospital Fort Smith Fort Smith Arkansas United States 72903
    12 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    13 Kaiser Permanente-Anaheim Anaheim California United States 92806
    14 Kaiser Permanente-Deer Valley Medical Center Antioch California United States 94531
    15 Mission Hope Medical Oncology - Arroyo Grande Arroyo Grande California United States 93420
    16 PCR Oncology Arroyo Grande California United States 93420
    17 Kaiser Permanente-Baldwin Park Baldwin Park California United States 91706
    18 Kaiser Permanente-Bellflower Bellflower California United States 90706
    19 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    20 Kaiser Permanente Dublin Dublin California United States 94568
    21 Kaiser Permanente-Fontana Fontana California United States 92335
    22 Kaiser Permanente-Fremont Fremont California United States 94538
    23 Fresno Cancer Center Fresno California United States 93720
    24 Kaiser Permanente-Fresno Fresno California United States 93720
    25 Kaiser Permanente - Harbor City Harbor City California United States 90710
    26 Kaiser Permanente-Irvine Irvine California United States 92618
    27 Kaiser Permanente Los Angeles Medical Center Los Angeles California United States 90027
    28 Los Angeles County-USC Medical Center Los Angeles California United States 90033
    29 USC / Norris Comprehensive Cancer Center Los Angeles California United States 90033
    30 Kaiser Permanente West Los Angeles Los Angeles California United States 90034
    31 Cedars Sinai Medical Center Los Angeles California United States 90048
    32 Kaiser Permanente-Modesto Modesto California United States 95356
    33 Kaiser Permanente Oakland-Broadway Oakland California United States 94611
    34 Kaiser Permanente-Oakland Oakland California United States 94611
    35 Kaiser Permanente-Ontario Ontario California United States 91761
    36 UC Irvine Health/Chao Family Comprehensive Cancer Center Orange California United States 92868
    37 Kaiser Permanente - Panorama City Panorama City California United States 91402
    38 Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California United States 95670
    39 Kaiser Permanente-Redwood City Redwood City California United States 94063
    40 Kaiser Permanente-Richmond Richmond California United States 94801
    41 Kaiser Permanente-Riverside Riverside California United States 92505
    42 Rohnert Park Cancer Center Rohnert Park California United States 94928
    43 Kaiser Permanente-Roseville Roseville California United States 95661
    44 The Permanente Medical Group-Roseville Radiation Oncology Roseville California United States 95678
    45 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    46 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    47 South Sacramento Cancer Center Sacramento California United States 95823
    48 Kaiser Permanente-San Diego Mission San Diego California United States 92108
    49 Kaiser Permanente-San Diego Zion San Diego California United States 92120
    50 Kaiser Permanente-San Francisco San Francisco California United States 94115
    51 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    52 Kaiser Permanente San Leandro San Leandro California United States 94577
    53 Pacific Central Coast Health Center-San Luis Obispo San Luis Obispo California United States 93401
    54 Kaiser Permanente-San Marcos San Marcos California United States 92078
    55 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    56 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    57 Mission Hope Medical Oncology - Santa Maria Santa Maria California United States 93444
    58 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
    59 Kaiser Permanente Cancer Treatment Center South San Francisco California United States 94080
    60 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    61 Kaiser Permanente-Stockton Stockton California United States 95210
    62 Torrance Memorial Physician Network - Cancer Care Torrance California United States 90505
    63 Torrance Memorial Medical Center Torrance California United States 90509
    64 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    65 Kaiser Permanente-Vallejo Vallejo California United States 94589
    66 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    67 Kaiser Permanente-Woodland Hills Woodland Hills California United States 91367
    68 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    69 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    70 Porter Adventist Hospital Denver Colorado United States 80210
    71 Mercy Medical Center Durango Colorado United States 81301
    72 Southwest Oncology PC Durango Colorado United States 81301
    73 Saint Anthony Hospital Lakewood Colorado United States 80228
    74 Littleton Adventist Hospital Littleton Colorado United States 80122
    75 Longmont United Hospital Longmont Colorado United States 80501
    76 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    77 Parker Adventist Hospital Parker Colorado United States 80138
    78 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    79 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    80 Beebe Medical Center Lewes Delaware United States 19958
    81 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    82 Helen F Graham Cancer Center Newark Delaware United States 19713
    83 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    84 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    85 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    86 TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware United States 19973
    87 Christiana Care Health System-Wilmington Hospital Wilmington Delaware United States 19801
    88 AdventHealth Altamonte Altamonte Springs Florida United States 32701
    89 AdventHealth Celebration Celebration Florida United States 34747
    90 Holy Cross Hospital Fort Lauderdale Florida United States 33308
    91 AdventHealth Kissimmee Kissimmee Florida United States 34744
    92 AdventHealth Medical Group Urology at Orlando Orlando Florida United States 32803
    93 AdventHealth Orlando Orlando Florida United States 32803
    94 AdventHealth East Orlando Orlando Florida United States 32822
    95 Sacred Heart Hospital Pensacola Florida United States 32504
    96 AdventHealth Winter Park Winter Park Florida United States 32792
    97 Lewis Hall Singletary Oncology Center Thomasville Georgia United States 31792
    98 Kaiser Permanente Moanalua Medical Center Honolulu Hawaii United States 96819
    99 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    100 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    101 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    102 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    103 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    104 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    105 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    106 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    107 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    108 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    109 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    110 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    111 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    112 Saint Anthony's Health Alton Illinois United States 62002
    113 Rush - Copley Medical Center Aurora Illinois United States 60504
    114 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    115 Illinois CancerCare-Canton Canton Illinois United States 61520
    116 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    117 SIH Cancer Institute Carterville Illinois United States 62918
    118 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    119 Centralia Oncology Clinic Centralia Illinois United States 62801
    120 Northwestern University Chicago Illinois United States 60611
    121 Rush University Medical Center Chicago Illinois United States 60612
    122 University of Illinois Chicago Illinois United States 60612
    123 Carle on Vermilion Danville Illinois United States 61832
    124 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    125 Decatur Memorial Hospital Decatur Illinois United States 62526
    126 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    127 Carle Physician Group-Effingham Effingham Illinois United States 62401
    128 Crossroads Cancer Center Effingham Illinois United States 62401
    129 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    130 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    131 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    132 Ingalls Memorial Hospital Harvey Illinois United States 60426
    133 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    134 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    135 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    136 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    137 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    138 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    139 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    140 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    141 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    142 Illinois CancerCare-Peru Peru Illinois United States 61354
    143 Valley Radiation Oncology Peru Illinois United States 61354
    144 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    145 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    146 Springfield Clinic Springfield Illinois United States 62702
    147 Memorial Medical Center Springfield Illinois United States 62781
    148 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    149 Carle Cancer Center Urbana Illinois United States 61801
    150 The Carle Foundation Hospital Urbana Illinois United States 61801
    151 Illinois CancerCare - Washington Washington Illinois United States 61571
    152 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    153 Reid Health Richmond Indiana United States 47374
    154 Mary Greeley Medical Center Ames Iowa United States 50010
    155 McFarland Clinic PC - Ames Ames Iowa United States 50010
    156 McFarland Clinic PC-Boone Boone Iowa United States 50036
    157 Saint Anthony Regional Hospital Carroll Iowa United States 51401
    158 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    159 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    160 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    161 Greater Regional Medical Center Creston Iowa United States 50801
    162 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    163 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    164 Broadlawns Medical Center Des Moines Iowa United States 50314
    165 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    166 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    167 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    168 McFarland Clinic PC-Trinity Cancer Center Fort Dodge Iowa United States 50501
    169 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    170 McFarland Clinic PC-Jefferson Jefferson Iowa United States 50129
    171 McFarland Clinic PC-Marshalltown Marshalltown Iowa United States 50158
    172 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    173 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    174 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    175 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    176 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    177 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    178 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    179 Saint Joseph Hospital East Lexington Kentucky United States 40509
    180 Saint Joseph London London Kentucky United States 40741
    181 Jewish Hospital Louisville Kentucky United States 40202
    182 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    183 UofL Health Medical Center Northeast Louisville Kentucky United States 40245
    184 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    185 LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana United States 70805
    186 Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana United States 70809
    187 Louisiana State University Health Science Center New Orleans Louisiana United States 70112
    188 University Medical Center New Orleans New Orleans Louisiana United States 70112
    189 UMass Memorial Medical Center - University Campus Worcester Massachusetts United States 01655
    190 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    191 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    192 Bronson Battle Creek Battle Creek Michigan United States 49017
    193 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    194 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    195 Saint Joseph Mercy Canton Canton Michigan United States 48188
    196 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    197 Caro Cancer Center Caro Michigan United States 48723
    198 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    199 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    200 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    201 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    202 Ascension Saint John Hospital Detroit Michigan United States 48236
    203 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    204 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    205 Genesee Hematology Oncology PC Flint Michigan United States 48503
    206 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    207 Hurley Medical Center Flint Michigan United States 48503
    208 Helen DeVos Children's Hospital at Spectrum Health Grand Rapids Michigan United States 49503
    209 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    210 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    211 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    212 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    213 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    214 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    215 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    216 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    217 Borgess Medical Center Kalamazoo Michigan United States 49048
    218 Sparrow Hospital Lansing Michigan United States 48912
    219 Hope Cancer Clinic Livonia Michigan United States 48154
    220 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    221 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    222 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    223 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    224 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    225 Lakeland Hospital Niles Niles Michigan United States 49120
    226 Cancer and Hematology Centers of Western Michigan - Norton Shores Norton Shores Michigan United States 49444
    227 Ascension Providence Hospitals - Novi Novi Michigan United States 48374
    228 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    229 Hope Cancer Center Pontiac Michigan United States 48341
    230 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    231 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    232 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    233 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    234 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    235 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    236 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    237 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    238 Ascension Providence Hospitals - Southfield Southfield Michigan United States 48075
    239 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    240 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    241 Munson Medical Center Traverse City Michigan United States 49684
    242 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    243 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    244 Macomb Hematology Oncology PC Warren Michigan United States 48093
    245 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    246 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    247 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    248 Metro Health Hospital Wyoming Michigan United States 49519
    249 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    250 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    251 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    252 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    253 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    254 Cambridge Medical Center Cambridge Minnesota United States 55008
    255 Mercy Hospital Coon Rapids Minnesota United States 55433
    256 Fairview Southdale Hospital Edina Minnesota United States 55435
    257 Unity Hospital Fridley Minnesota United States 55432
    258 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    259 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    260 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    261 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    262 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    263 Health Partners Inc Minneapolis Minnesota United States 55454
    264 Monticello Cancer Center Monticello Minnesota United States 55362
    265 New Ulm Medical Center New Ulm Minnesota United States 56073
    266 Fairview Northland Medical Center Princeton Minnesota United States 55371
    267 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    268 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    269 Regions Hospital Saint Paul Minnesota United States 55101
    270 United Hospital Saint Paul Minnesota United States 55102
    271 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    272 Lakeview Hospital Stillwater Minnesota United States 55082
    273 Sanford Thief River Falls Medical Center Thief River Falls Minnesota United States 56701
    274 Ridgeview Medical Center Waconia Minnesota United States 55387
    275 Rice Memorial Hospital Willmar Minnesota United States 56201
    276 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    277 Sanford Cancer Center Worthington Worthington Minnesota United States 56187
    278 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    279 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    280 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    281 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    282 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    283 Saint Luke's Hospital Chesterfield Missouri United States 63017
    284 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    285 Parkland Health Center - Farmington Farmington Missouri United States 63640
    286 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    287 Freeman Health System Joplin Missouri United States 64804
    288 Mercy Hospital Joplin Joplin Missouri United States 64804
    289 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    290 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    291 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    292 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    293 Washington University School of Medicine Saint Louis Missouri United States 63110
    294 Mercy Hospital South Saint Louis Missouri United States 63128
    295 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    296 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    297 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    298 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    299 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    300 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    301 Mercy Hospital Springfield Springfield Missouri United States 65804
    302 CoxHealth South Hospital Springfield Missouri United States 65807
    303 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    304 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    305 Mercy Hospital Washington Washington Missouri United States 63090
    306 Community Hospital of Anaconda Anaconda Montana United States 59711
    307 Billings Clinic Cancer Center Billings Montana United States 59101
    308 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    309 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    310 Great Falls Clinic Great Falls Montana United States 59405
    311 Kalispell Regional Medical Center Kalispell Montana United States 59901
    312 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    313 Community Medical Hospital Missoula Montana United States 59804
    314 Nebraska Medicine-Bellevue Bellevue Nebraska United States 68123
    315 CHI Health Saint Francis Grand Island Nebraska United States 68803
    316 CHI Health Good Samaritan Kearney Nebraska United States 68847
    317 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    318 Nebraska Medicine-Village Pointe Omaha Nebraska United States 68118
    319 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    320 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    321 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    322 Creighton University Medical Center Omaha Nebraska United States 68131
    323 University of Nebraska Medical Center Omaha Nebraska United States 68198
    324 Midlands Community Hospital Papillion Nebraska United States 68046
    325 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    326 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    327 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    328 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    329 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    330 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    331 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    332 GenesisCare USA - Henderson Henderson Nevada United States 89074
    333 Las Vegas Urology - Green Valley Henderson Nevada United States 89074
    334 Las Vegas Urology - Pebble Henderson Nevada United States 89074
    335 Urology Specialists of Nevada - Green Valley Henderson Nevada United States 89074
    336 Las Vegas Urology - Pecos Las Vegas Nevada United States 89074
    337 Desert West Surgery Las Vegas Nevada United States 89102
    338 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    339 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    340 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    341 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    342 Urology Specialists of Nevada - Central Las Vegas Nevada United States 89106
    343 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    344 Sunrise Hospital and Medical Center Las Vegas Nevada United States 89109
    345 Las Vegas Prostate Cancer Center Las Vegas Nevada United States 89113
    346 Las Vegas Urology - Sunset Las Vegas Nevada United States 89113
    347 Urology Specialists of Nevada - Southwest Las Vegas Nevada United States 89113
    348 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    349 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    350 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    351 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    352 Las Vegas Urology - Cathedral Rock Las Vegas Nevada United States 89128
    353 Las Vegas Urology - Smoke Ranch Las Vegas Nevada United States 89128
    354 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    355 Urology Specialists of Nevada - Northwest Las Vegas Nevada United States 89128
    356 Alliance for Childhood Diseases/Cure 4 the Kids Foundation Las Vegas Nevada United States 89135
    357 Comprehensive Cancer Centers of Nevada - Town Center Las Vegas Nevada United States 89144
    358 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    359 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    360 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    361 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    362 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    363 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    364 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    365 University Cancer Center Las Vegas Nevada United States 89169
    366 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    367 Renown Regional Medical Center Reno Nevada United States 89502
    368 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    369 Radiation Oncology Associates Reno Nevada United States 89509
    370 New Hampshire Oncology Hematology PA-Concord Concord New Hampshire United States 03301
    371 Solinsky Center for Cancer Care Manchester New Hampshire United States 03103
    372 Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey United States 07920
    373 Memorial Sloan Kettering Monmouth Middletown New Jersey United States 07748
    374 Memorial Sloan Kettering Bergen Montvale New Jersey United States 07645
    375 Roswell Park Cancer Institute Buffalo New York United States 14263
    376 Memorial Sloan Kettering Commack Commack New York United States 11725
    377 Memorial Sloan Kettering Westchester Harrison New York United States 10604
    378 Memorial Sloan Kettering Cancer Center New York New York United States 10065
    379 Memorial Sloan Kettering Nassau Uniondale New York United States 11553
    380 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    381 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    382 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    383 FirstHealth of the Carolinas-Moore Regional Hospital Pinehurst North Carolina United States 28374
    384 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    385 Sanford South University Medical Center Fargo North Dakota United States 58103
    386 Southpointe-Sanford Medical Center Fargo Fargo North Dakota United States 58103
    387 Sanford Medical Center Fargo Fargo North Dakota United States 58104
    388 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    389 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    390 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    391 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    392 Saint Elizabeth Boardman Hospital Boardman Ohio United States 44512
    393 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    394 Miami Valley Hospital South Centerville Ohio United States 45459
    395 Adena Regional Medical Center Chillicothe Ohio United States 45601
    396 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    397 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    398 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    399 Bethesda North Hospital Cincinnati Ohio United States 45242
    400 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    401 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    402 MetroHealth Medical Center Cleveland Ohio United States 44109
    403 Mount Carmel East Hospital Columbus Ohio United States 43213
    404 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    405 Riverside Methodist Hospital Columbus Ohio United States 43214
    406 Grant Medical Center Columbus Ohio United States 43215
    407 The Mark H Zangmeister Center Columbus Ohio United States 43219
    408 Mount Carmel Health Center West Columbus Ohio United States 43222
    409 Doctors Hospital Columbus Ohio United States 43228
    410 Miami Valley Hospital Dayton Ohio United States 45409
    411 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    412 Miami Valley Hospital North Dayton Ohio United States 45415
    413 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    414 Grady Memorial Hospital Delaware Ohio United States 43015
    415 Dublin Methodist Hospital Dublin Ohio United States 43016
    416 Armes Family Cancer Center Findlay Ohio United States 45840
    417 Blanchard Valley Hospital Findlay Ohio United States 45840
    418 Orion Cancer Care Findlay Ohio United States 45840
    419 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    420 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    421 Central Ohio Breast and Endocrine Surgery Gahanna Ohio United States 43230
    422 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    423 Wayne Hospital Greenville Ohio United States 45331
    424 Mount Carmel Grove City Hospital Grove City Ohio United States 43123
    425 Greater Dayton Cancer Center Kettering Ohio United States 45409
    426 Kettering Medical Center Kettering Ohio United States 45429
    427 Fairfield Medical Center Lancaster Ohio United States 43130
    428 Saint Rita's Medical Center Lima Ohio United States 45801
    429 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    430 Marietta Memorial Hospital Marietta Ohio United States 45750
    431 OhioHealth Marion General Hospital Marion Ohio United States 43302
    432 Knox Community Hospital Mount Vernon Ohio United States 43050
    433 Licking Memorial Hospital Newark Ohio United States 43055
    434 Newark Radiation Oncology Newark Ohio United States 43055
    435 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    436 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    437 Springfield Regional Cancer Center Springfield Ohio United States 45504
    438 Springfield Regional Medical Center Springfield Ohio United States 45505
    439 Saint Vincent Mercy Medical Center Toledo Ohio United States 43608
    440 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    441 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    442 Upper Valley Medical Center Troy Ohio United States 45373
    443 Saint Joseph Warren Hospital Warren Ohio United States 44484
    444 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    445 Saint Ann's Hospital Westerville Ohio United States 43081
    446 Saint Elizabeth Youngstown Hospital Youngstown Ohio United States 44501
    447 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    448 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    449 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    450 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    451 Saint Charles Health System Bend Oregon United States 97701
    452 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    453 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    454 Bay Area Hospital Coos Bay Oregon United States 97420
    455 Providence Newberg Medical Center Newberg Oregon United States 97132
    456 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    457 Providence Portland Medical Center Portland Oregon United States 97213
    458 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    459 Oregon Health and Science University Portland Oregon United States 97239
    460 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    461 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    462 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    463 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    464 Geisinger Medical Center Danville Pennsylvania United States 17822
    465 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    466 Geisinger Medical Center-Cancer Center Hazleton Hazleton Pennsylvania United States 18201
    467 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    468 Geisinger Medical Oncology-Lewisburg Lewisburg Pennsylvania United States 17837
    469 Pennsylvania Hospital Philadelphia Pennsylvania United States 19107
    470 Geisinger Cancer Services-Pottsville Pottsville Pennsylvania United States 17901
    471 Community Medical Center Scranton Pennsylvania United States 18510
    472 Geisinger Wyoming Valley/Henry Cancer Center Wilkes-Barre Pennsylvania United States 18711
    473 Saint Francis Hospital Greenville South Carolina United States 29601
    474 Saint Francis Cancer Center Greenville South Carolina United States 29607
    475 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    476 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    477 Thompson Cancer Survival Center Knoxville Tennessee United States 37916
    478 Thompson Cancer Survival Center - West Knoxville Tennessee United States 37932
    479 Thompson Oncology Group-Lenoir City Lenoir City Tennessee United States 37772
    480 Vanderbilt University/Ingram Cancer Center Nashville Tennessee United States 37232
    481 Thompson Oncology Group-Oak Ridge Oak Ridge Tennessee United States 37830
    482 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    483 Parkland Memorial Hospital Dallas Texas United States 75235
    484 UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas United States 75390
    485 M D Anderson Cancer Center Houston Texas United States 77030
    486 Cancer Specialists of Tidewater Limited Chesapeake Virginia United States 23320
    487 Peninsula Cancer Institute-Gloucester Gloucester Virginia United States 23061
    488 Peninsula Cancer Institute-Newport News Newport News Virginia United States 23601
    489 Virginia Cancer Institute Richmond Virginia United States 23229
    490 Virginia Commonwealth University/Massey Cancer Center Richmond Virginia United States 23298
    491 Cancer Specialists of Tidewater-Suffolk Suffolk Virginia United States 23435
    492 Peninsula Cancer Institute-Cancer Specialists of Tidewater Virginia Beach Virginia United States 23454
    493 Peninsula Cancer Institute-Williamsburg Williamsburg Virginia United States 23185
    494 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    495 Overlake Medical Center Bellevue Washington United States 98004
    496 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    497 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    498 Harrison Medical Center Bremerton Washington United States 98310
    499 Highline Medical Center-Main Campus Burien Washington United States 98166
    500 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    501 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    502 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    503 Providence Regional Cancer Partnership Everett Washington United States 98201
    504 Saint Francis Hospital Federal Way Washington United States 98003
    505 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    506 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    507 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    508 Saint Clare Hospital Lakewood Washington United States 98499
    509 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    510 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    511 Valley Medical Center Renton Washington United States 98055
    512 Pacific Gynecology Specialists Seattle Washington United States 98104
    513 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    514 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    515 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    516 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    517 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    518 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    519 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    520 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    521 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    522 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    523 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    524 United Hospital Center Bridgeport West Virginia United States 26330
    525 WVUH-Berkely Medical Center Martinsburg West Virginia United States 25401
    526 West Virginia University Healthcare Morgantown West Virginia United States 26506
    527 Camden Clark Medical Center Parkersburg West Virginia United States 26101
    528 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    529 Gundersen Lutheran Medical Center La Crosse Wisconsin United States 54601
    530 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    531 Medical College of Wisconsin Milwaukee Wisconsin United States 53226
    532 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    533 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    534 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    535 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    536 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    537 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    538 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    539 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    540 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    541 Billings Clinic-Cody Cody Wyoming United States 82414
    542 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Cathy Eng, ECOG-ACRIN Cancer Research Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT04444921
    Other Study ID Numbers:
    • NCI-2020-04334
    • NCI-2020-04334
    • EA2176
    • EA2176
    • U10CA180820
    First Posted:
    Jun 24, 2020
    Last Update Posted:
    Aug 24, 2022
    Last Verified:
    Jun 1, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Carcinoma
    Carcinoma, Squamous Cell
    Anus Neoplasms
    Paclitaxel
    Carboplatin
    Nivolumab
    Albumin-Bound Paclitaxel

    Study Results

    No Results Posted as of Aug 24, 2022