Parasitic Infection in Anemic Pregnant Women
Study Details
Study Description
Brief Summary
Women included between 18 and 45 years old, pregnant during their second or third trimester of pregnancy (calculated by a sure menstrual date and confirmed by a 1st trimesteric ultrasound) with hemoglobin level below 10.5 mg /dL.
Condition or Disease | Intervention/Treatment | Phase |
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|
Phase 4 |
Detailed Description
All patients in the study were subjected to:
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Detailed history was recorded. A proper history concerning age, sex, residence, socioeconomic status, onset, progression, and previous treatment of anemia was taken. Participants' socio-demographic characteristics including gravida and parity were documented, level of education, occupation, Diet, and information useful to determine the socioeconomic level was recorded. Information on previous pregnancies and children and history of chronic diseases were also recorded.
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General examination; patients were clinically examined and gestational age (assessed by measuring the fundal height), weight was calculated for each participant.
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Diagnosis of anemia by Complete blood count (CBC), Hb level and measuring hematocrit concentration.
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Diagnosis of parasitic infection by stool analysis using suitable techniques.
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Imaging including obstetric ultrasound (U/S) to assess fetal development.
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Women with helminthic infections will be divided into groups
Group (A): received iron + antiparasitic treatment as follows:
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Patients who have STH received alzental 200mg tab 2 tabs single oral dose.
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Patients who have Entamoeba or Giardia received flagyl 500mg tab twice daily for 5 days.
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(B): received iron only.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Active Comparator: Anemia without parasitic infection women with anemia without parasitic infection will receive iron treatment |
Drug: Iron Supplement
oral tablet twice daily after meals
Other Names:
|
Active Comparator: parasitic infection treated with iron women with anemia with parasitic infection will receive oral iron treatment |
Drug: Iron Supplement
oral tablet twice daily after meals
Other Names:
|
Active Comparator: parasitic infection treated with iron and antihelmemsic women with anemia with parasitic infection will receive oral iron treatment and antihelminsic treatment in the form of metronidazole 500mg tab twice daily for 5 days in cases with Entamoeba or Giardia or albendazol 200mg tab |
Drug: Iron Supplement
oral tablet twice daily after meals
Other Names:
Drug: Metronidazole Oral
500 mg oral twice daily
Other Names:
Drug: Albendazole
200 mg oral single dose
Other Names:
|
Outcome Measures
Primary Outcome Measures
- correction of naemia [6 weeks after treatment]
hemoglobin level increased above 11 gm/dL
Eligibility Criteria
Criteria
Inclusion Criteria:
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pregnant during their second or third trimester of pregnancy (calculated by a sure menstrual date and confirmed by a 1st trimesteric ultrasound)
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hemoglobin level below 10.5 mg /dL
Exclusion Criteria:
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women with chronic diseases as diabetes, heart, renal, hepatic or endocrinological disorders
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women diagnosed with blood diseases as hemoglobinopathy or vascular diseases as vasculitis.
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Women with autoimmune diseases and those allergic to iron or antihelminsic treatment were also excluded
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Kasr Alainy medical school | Cairo | Egypt | 12151 |
Sponsors and Collaborators
- Cairo University
Investigators
- Principal Investigator: Ahmed maged, MD, Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 175