Dexamethasone Plus Bupivacaine Versus Bupivacaine in Bilateral Trans-incisional Paravertebral Block in Lumbar Spine Surgeries .
Study Details
Study Description
Brief Summary
The purpose of this study is to compare addition of dexamethasone to bupivacaine versus bupivacaine alone for trans-incisional bilateral paravertebral block for postoperative analgesia in elective lumbar spine surgeries.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Dexamethasone + bupivacaine in bilateral TiPVB in lumbar spine surgery Dexamethasone plus bupivacaine in bilateral trans-incisional paravertebral block in lumbar spine surgery for postoperative analgesia |
Drug: Dexamethasone+ Bupivacaine
Dexamethasone plus bupivacaine in bilateral trans-incisional paravertebral block in lumbar spine surgery.
|
Active Comparator: Bupivacaine in bilateral TiPVB in lumbar spine surgery Bupivacaine in bilateral trans-incisional paravertebral block in lumbar spine surgery for postoperative analgesia |
Drug: Bupivacaine
Bupivacaine in bilateral trans-incisional paravertebral block in lumbar spine surgery.
|
Outcome Measures
Primary Outcome Measures
- First time to analgesic requirement [1st 24 hour]
After extubation, an IV PCA system will be connected to the patient (Accufuser PlusĀ® 100 mL: Woo Young Medical Co, Korea). PCA will be prepared with 60 mL of normal saline containing 60 mg of morphine, and the system will be programmed to give a 0.5 mL bolus dose with a lockout interval of 8 min. basal rate will not be present. PCA will be discontinued at 24 h after surgery, and at that time, oral analgesics begin.
Secondary Outcome Measures
- Total opioid consumption . [1st 24 hour]
Total opioid consumption in the first 24 h postoperatively .
- Visual analogue scale (VAS) [1st 24 hours postoperatively]
Pain scores will be evaluated by a blinded observer anesthesiologist at the time of arrival in the PACU and 10, 20, and 30 min and 1, 2, 4, 6, 12, and 24 h thereafter using a visual analog scale (VAS) (ranging from0-10 cm: where 0 = no pain, 10 = worst pain). The patients Will be instructed about the usage of the PCA system and the VAS preoperatively
Eligibility Criteria
Criteria
Inclusion Criteria:
- physical status American Society of Anesthesiologists (ASA) I or II.
Exclusion Criteria:
- refuse to participate have a body mass index (BMI) >30 kg/m2 ASA physical status >II have major illnesses (e.g., cardiac, respiratory, renal, hepatic or neurological) coagulation abnormalities infection at the injection site tumor in the paravertebral space sepsis Severe chest deformity or scoliosis, due to the possibility of injection into the meninges an allergy or contraindications to the drugs used in the study uncontrolled diabetes patients with active gastric ulceration a history of drug addiction or alcohol abuse a psychiatric illness mental retardation interfering with the evaluation of pain scores.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Ain Shams University hospitals | Cairo | Egypt |
Sponsors and Collaborators
- Ain Shams University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- FMASU R 47/2020/2021