Anti-Inflammatory Effects of Time-Restricted Feeding

Sponsor
National Heart, Lung, and Blood Institute (NHLBI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT04728165
Collaborator
(none)
30
1
50.8
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Study Details

Study Description

Brief Summary

Background:

Time-restricted feeding (TRF) means that a person eats only during certain hours of the day. In other studies, researchers have found that fasting can improve immune system function in healthy people. They want to see if TRF has the same effect on people with psoriasis.

Objective:

To test whether TRF can change metabolism and decrease some markers of inflammation in the blood of people with mild to moderate psoriasis.

Eligibility:

Males ages 18 to 80 with mild to moderate active psoriasis, and healthy volunteers

Design:

Participants will be screened with a medical history and medicine review. They will have a physical exam and blood tests. Their skin will be examined. They will have a nutritional evaluation. Their resting energy expenditure will be measured. For this, a clear plastic ventilation hood will be placed over the head for a short time.

Participants will stay at the NIH Clinical Center for 4 1/2 days. They can watch TV, do work, do schoolwork, and other quiet activities.

A small sensor will be placed under participants skin to measure blood glucose.

For part of the study, participants will be housed in a small room called a metabolic chamber. They will wear a heart monitor.

Participants will walk on a treadmill for 30 minutes each day at a comfortable speed.

For 3 days, participants will eat all their daily calories between 8 am and 2 pm. They will fast for the other 18 hours of the day. They can drink water.

Participants will complete mixed meal tests. They will drink a liquid meal for breakfast. Then they will give blood samples via intravenous (IV) catheter.

Participation will last for 5 days....

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Study Description:

    Fasting and caloric restriction interventions have anti-inflammatory effects, although the underling regulatory controls are poorly characterized. This pilot study will explore transcriptional profiles in various leukocyte populations comparing the effect of time restricted feeding (TRF - 6-Hr feeding/18-Hr fast) to a more conventional dietary regimen (12-Hr feeding/12Hr fast). These regulatory effects will be evaluated in an inflammatory disease (psoriasis) in response to TRF and by comparing the relative response comparing the psoriasis populationto a matched TRF control group.

    Objectives:
    1. Evaluate the effect of TRF on Th17 immunological signatures.

    2. Compare the role of TRF on chromatin remodeling on CD4+ T cells, monocytes and neutrophils comparing control and

    psoriatic subjects.

    1. Evaluate the effect of TRF on glucose and insulin metabolism and overall metabolic flexibility.
    Endpoints:

    The primary outcome will be the change in the secretion of IL-17 from activated CD4+ T cells from baseline to the end of TRF as a measure of biological reprograming in the psoriasis group and to assess the change in IL-17 release comparing the effects of TRF in the control versus psoriasis groups.

    Secondary outcomes are:
    1. Evaluate the effect of TRF on chromatin signatures of gene activation (ATACseq) and gene silencing (H3K9me3).

    2. Explore the effect of TRF on low-density granulocytes, neutrophils and monocytes.

    3. Evaluate whether TRF improves 24-hour glucose levels, glycemic excursions during a meal test and modulate sleeping

    and feeding metabolic flexibility as defined by the change in sleeping respiratory exchange ratio from the daytime. (24-hr

    substrate oxidation as defined by the averaged RER)

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    30 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Pilot Study to Explore the Anti-Inflammatory Effects of Time-Restricted Feeding
    Actual Study Start Date :
    Jun 9, 2021
    Anticipated Primary Completion Date :
    Sep 1, 2024
    Anticipated Study Completion Date :
    Sep 1, 2025

    Arms and Interventions

    Arm Intervention/Treatment
    control group

    Age (+/-5 yrs) and BMI (+/- 5 kg/m2) matched control male subjects for inclusion in the control group

    psoriasis group

    Males between the ages of 18 and 70 with mild to moderate active psoriasis by PASI score for inclusion in psoriasis group

    Outcome Measures

    Primary Outcome Measures

    1. change in the secretion of IL-17 from activated CD4+ T cells from baseline to the end of TRF [4 years]

      The primary outcome will be the change in the secretion of IL-17 from activated CD4+ T cells from baseline to the end of TRF as a measure of biological reprograming in the psoriasis group and to assess the change in IL-17 release comparing the effects of TRF in the control versus psoriasis groups.

    Secondary Outcome Measures

    1. Evaluate the effect of TRF on chromatin signatures of gene activation (ATACseq) and gene silencing (H3K9me3) [5 years]

      Evaluate the effect of TRF on chromatin signatures of gene activation (ATACseq) and gene silencing (H3K9me3)

    2. Explore the effect of TRF on low-density granulocytes, neutrophils and monocytes [5 years]

      Explore the effect of TRF on low-density granulocytes, neutrophils and monocytes.

    3. Evaluate whether TRF improves 24-hour glucose levels, glycemic excursions during a meal test and modulate sleeping and feeding metabolic flexibility as defined by the change in sleeping respiratory exchange ratio from the daytime. (24-hr substra... [4 years]

      Evaluate whether TRF improves 24-hour glucose levels, glycemic excursions during a meal test and modulate sleeping and feeding metabolic flexibility as defined by the change in sleeping respiratory exchange ratio from the daytime. (24-hr substrate oxidation as defined by the averaged RER)

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 80 Years
    Sexes Eligible for Study:
    Male
    Accepts Healthy Volunteers:
    Yes
    • INCLUSION CRITERIA:

    Individuals must meet the inclusion criteria listed below in order to be eligible to participate in the study.

    • Males between the ages of 18 and 80 with mild to moderate active psoriasis by PASI score for inclusion in psoriasis group

    • Age (plus or minus 10 yrs) and BMI (plus or minus 5 kg/m^2) matched control male subjects for inclusion in the control group.

    • Ability to provide informed consent

    • Willingness and ability to participate in study procedures

    EXCLUSION CRITERIA:
    • Severe psoriasis by PASI (Psoriasis Area and Severity Index) score > 12

    • Treatment with systemic biologic immune modifying agents within the last 2 months.

    • Currently on treatment for allergies or other inflammatory diseases.

    • Has taken Vitamin B or tryptophan supplementation within 2 weeks of participation.

    • Unwillingness/inability to provide informed consent.

    • Individuals with known history of type 1 and 2 diabetes mellitus or other metabolic conditions that would interfere with study parameters including chronic kidney disease, chronic liver disease, history of hypoglycemia

    • On treatment with medication that would interfere with study parameters including antihyperglycemic medications, systemic steroids, adrenergic-stimulating agents, other medications known to affect sleep, circadian rhythms or metabolism.

    • Caffeine in excess of three 8 oz cups per day.

    • Factors that affect circadian rhythm including individuals who perform overnight shift work, irregular sleep and/ or eating schedules, regularly fast for more than 15 hours/ day

    • Regular use of tobacco product within last 3 months.

    • Consuming more than 3 servings of alcohol/ day

    • Engaged in competitive sports training

    • Moderate to severe claustrophobia

    • Unstable weight with more than 5% body weight change in last 3 months

    • Food allergies or intolerances or dietary patterns that would prohibit consumption of the metabolic diet or mixed meal test.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 National Institutes of Health Clinical Center Bethesda Maryland United States 20892

    Sponsors and Collaborators

    • National Heart, Lung, and Blood Institute (NHLBI)

    Investigators

    • Principal Investigator: Michael N Sack, M.D., National Heart, Lung, and Blood Institute (NHLBI)

    Study Documents (Full-Text)

    None provided.

    More Information

    Additional Information:

    Publications

    None provided.
    Responsible Party:
    National Heart, Lung, and Blood Institute (NHLBI)
    ClinicalTrials.gov Identifier:
    NCT04728165
    Other Study ID Numbers:
    • 10000149
    • 000149-H
    First Posted:
    Jan 28, 2021
    Last Update Posted:
    Jul 7, 2022
    Last Verified:
    May 12, 2022
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by National Heart, Lung, and Blood Institute (NHLBI)
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Jul 7, 2022