Computerized Intervention Targeting the Error-Related Negativity and Balance N1 in Anxious Children

Sponsor
Florida State University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05503017
Collaborator
National Institute of Mental Health (NIMH) (NIH)
80
2
21

Study Details

Study Description

Brief Summary

Anxiety disorders are the most common form of psychopathology, and frequently begin in childhood, resulting in lifelong impairment. Increased brain activity after making mistakes, as reflected by the error-related negativity (ERN), is observed in people with anxiety disorders, even before disorder onset. The ERN is therefore of great interest as a potentially modifiable risk factor for anxiety. However, methodological issues can make the ERN difficult to measure.

Increased brain activity in response to a balance disturbance, as reflected by the balance N1, resembles the ERN, but does not share its methodological issues. The investigators' preliminary data demonstrate that the balance N1 and the ERN are associated in amplitude in adults, suggesting they may depend on the same brain processes. The balance N1 has never been investigated in individuals with anxiety disorders, but it increases in amplitude within individuals under anxiety-inducing environmental contexts. Further, balance and anxiety are related in terms of brain anatomy, daily behavior, disorder presentation, and response to treatment.

The present investigation will measure the ERN and the balance N1 in children (ages 9-12) with anxiety disorders, and further, how these brain activity measures change in response to a brief, 45-minute, computerized psychosocial intervention that was developed to reduce reactivity to errors, and has been shown to reduce the ERN. The investigators will recruit approximately 80 children with anxiety disorders, half of whom will be randomly assigned to the active intervention condition. The other half will be assigned to an active control condition, consisting of a different 45-minute computerized presentation. Participants assigned to the control condition can access the computerized intervention after participation in the study.

The purpose of this investigation is to test the hypothesis that the balance N1 and the ERN will be reduced to a similar extent after the intervention, to demonstrate that these brain responses arise from shared brain processes. Transfer of the effect of the psycho-social intervention to the balance N1 would provide insight into prior work demonstrating that balance training can alleviate anxiety in young children, and well-documented benefits of psychotherapy to balance disorders. Collectively, these data may guide the development of multidisciplinary interventions for the prevention and treatment of anxiety disorders in children.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Psycho-social, computerized intervention targeting error sensitivity
  • Behavioral: Psycho-social, computerized intervention on healthy lifestyle choices
N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
80 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Outcomes Assessor)
Primary Purpose:
Basic Science
Official Title:
An Investigation of a Brief Psycho-Social Computerized Intervention Targeting the Error-Related Negativity and Balance N1 in Anxious Children
Anticipated Study Start Date :
Nov 1, 2022
Anticipated Primary Completion Date :
Aug 1, 2024
Anticipated Study Completion Date :
Aug 1, 2024

Arms and Interventions

Arm Intervention/Treatment
Experimental: Intervention

Behavioral: Psycho-social, computerized intervention targeting error sensitivity
The computer-based intervention is designed to directly reduce the sensitivity to errors through cognitive behavioral techniques. The intervention takes approximately 45 minutes and includes interactive quizzes, information, and behavioral tasks relevant to making mistakes, implications of making errors, and ways to deal with making mistakes, among other topics relevant to increased error sensitivity. The intervention uses developmentally appropriate language and stories that young children can relate to and understand.

Active Comparator: Control Condition

Behavioral: Psycho-social, computerized intervention on healthy lifestyle choices
The computer-based control condition will be in the same format and duration as the active intervention, but instead focuses on self-care topics and healthy lifestyle choices (e.g., eating healthy foods and getting a good night sleep), unrelated to error sensitivity.

Outcome Measures

Primary Outcome Measures

  1. Change in ERN after intervention [1 hour]

    The change in magnitude of the error-related negativity between baseline and reassessment after the intervention

  2. Change in balance N1 after intervention [1 hour]

    The change in magnitude of the error-related negativity between baseline and reassessment after the intervention

Eligibility Criteria

Criteria

Ages Eligible for Study:
9 Years to 12 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • English-speaking child

  • Must be able to stand for 15 minutes without assistance

  • Anxiety disorder (generalized anxiety disorder, social anxiety disorder, and/or obsessive-compulsive disorder)

Exclusion Criteria:
  • Depression or attention-deficit hyperactivity disorder

  • Significant medical condition, developmental disorder, or physical disability affecting the ability to stand

  • Severe psychopathology (e.g., bipolar disorder, psychosis, thought disorder, neurological disease, severe or extreme suicide risk)

  • Head injuries (over the past three months) that resulted in a loss of consciousness

  • Absence of an English-speaking primary caregiver that can accompany the child to the laboratory visit.

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Florida State University
  • National Institute of Mental Health (NIMH)

Investigators

  • Principal Investigator: Greg Hajcak, PhD, Florida State University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Greg Hajcak, Professor, Florida State University
ClinicalTrials.gov Identifier:
NCT05503017
Other Study ID Numbers:
  • STUDY00003181
First Posted:
Aug 16, 2022
Last Update Posted:
Aug 16, 2022
Last Verified:
Aug 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Aug 16, 2022