Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography

• Sponsor: Medical College of Wisconsin (Other)
• Overall Status: Recruiting
• CT.gov ID: NCT04620928
• Collaborator: (none)
• Enrollment: 12
• Location: 1
• Arm: 1
• Anticipated Duration (Months): 17
• Patients Per Site Per Month: 0.7

Study Details

Study Description

Brief Summary

This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts. To measure brain activity accurately, we will be using electrodes placed on people's brains during awake brain surgery.

Condition or Disease	Intervention/Treatment	Phase
Aphasia	Behavioral: Concepts	N/A

Detailed Description

This study will measure the dynamics of cortical activity among early modal cortex and multimodal cortical regions during conceptual retrieval using electrocorticography. Participants will be patients undergoing awake temporal lobe craniotomies. During the surgery patients will have multiple high-density grids placed to simultaneously record activity in multiple areas while the patient is performing language tasks. Activity in each of these regions will be tested for timing differences and informational directionality to determine the temporal dynamics.

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 12 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Intervention Model Description: Present a behavioral intervention to a single group of participants and measure subsequent electrical activity in the brain.Present a behavioral intervention to a single group of participants and measure subsequent electrical activity in the brain.
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography
• Actual Study Start Date: Aug 2, 2021
• Anticipated Primary Completion Date: Jan 1, 2023
• Anticipated Study Completion Date: Jan 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Concept Retrieval Patients will be given behavioral intervention, and their brain activity recorded.	Behavioral: Concepts; Images and sounds that are characteristic of various common objects.

Outcome Measures

Primary Outcome Measures

1. Brain activity [Recorded immediately during experiment]

   Electrocorticographic brain activity measured from brain surface

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Clinically determined to require an awake left temporal resection of a brain lesion with concurrent language testing.

• English as a first language.

Exclusion Criteria:

• Significant preoperative neuropsychological deficits in memory or naming.

• Patients with inability to make decisions regarding their participation in this research project.

• Surgeon does not plan to expose the area of interest or determines that recording during the resection will interfere with his surgical plan.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226

Sponsors and Collaborators

• Medical College of Wisconsin

Investigators

• Principal Investigator: William Gross, MD, PhD, Assistant Professor

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: William L Gross, MD PhD, Assistant Professor, Medical College of Wisconsin
• ClinicalTrials.gov Identifier: NCT04620928
• Other Study ID Numbers: PRO00038561
• First Posted: Nov 9, 2020
• Last Update Posted: Aug 10, 2021
• Last Verified: Aug 1, 2021

• Individual Participant Data (IPD) Sharing Statement: No
• Plan to Share IPD: No
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Aphasia

Study Results

No Results Posted as of Aug 10, 2021