Assessment of Histologic Prognostic Factors in Peritoneal Malignant Mesothelioma
Study Details
Study Description
Brief Summary
Malignant peritoneal mesothelioma is a rare neoplasm. The most common type, the epithelioid type, has been further divided into histological patterns of tubulo-papillary, acinar, adenomatoid, micropapillary, or solid. Its prognosis is improved by the use of a locoregional treatment combining extensive cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), which increases survival up to 50 months. Histology is one of the most important prognostic variable that, forms the basis for treatment decisions. However, the prognostic of the epithelioid type varies greatly due to its tumor heterogeneity. It is therefore necessary to find prognostic factors of malignant epithelioid peritoneal mesothelioma in order to better define the therapeutic strategy. Among histological factors, solid growth, tumor necrosis, nuclear atypia, and mitotic count were found to be independent prognostic factors in epithelioid malignant pleural mesothelioma. However, in epithelioid malignant peritoneal mesothelioma (EMPM), these factors were studied in small and heterogeneous series in terms of histological growth and definitions used for histological factors. The present large study was conducted to investigate the prognostic impact of several histologic factors in EMPM. Their prognosis impacts were assessed using overall survival (OS) and progression-free survival (PFS) in EMPM.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| peritoneal malignant mesothelioma of grade 1 peritoneal malignant mesothelioma of grade 1 |
Other: No intervention
No intervention
|
| peritoneal malignant mesothelioma of grade 2 peritoneal malignant mesothelioma of grade 2 |
Other: No intervention
No intervention
|
| peritoneal malignant mesothelioma of grade 3 peritoneal malignant mesothelioma of grade 3 |
Other: No intervention
No intervention
|
Outcome Measures
Primary Outcome Measures
- Assessment of pronostic impact of nuclear grade in comparison with combined grade in peritoneal malignant mesothelioma [3 months to 4 years]
Assessment by the review of pathologists
Eligibility Criteria
Criteria
Inclusion Criteria:
-
- peritoneal malignant mesothelioma
Exclusion Criteria:
- opposition to reuse personnal data
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | UZ Gent | Gent | Belgium | 9000 | |
| 2 | University Hospital of Lyon | Pierre-Bénite | France | 69495 | |
| 3 | Institut f. Pathologie und Neuropathologie | Tübingen | Germany | 72076 | |
| 4 | Zydus Hospitals | Ahmedabad | India | ||
| 5 | The Norwegian Radium Hospital | Oslo | Norway | N-0310 | |
| 6 | Fundação Champalimaud | Lisboa | Portugal | 1400-038 |
Sponsors and Collaborators
- Hospices Civils de Lyon
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 69HCL21_1120