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B-RAF V600E: Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease

Sponsor
HaEmek Medical Center, Israel (Other)
Overall Status
Completed
CT.gov ID
NCT01720758
Collaborator
(none)
20
Enrollment
5
Actual Duration (Months)

Study Details

Study Description

Brief Summary

The presence of a specific mutation in the gene known as B-RAF has been found in patients who have Hairy Cell Leukemia. In this study this specific mutation known as V600E will be ascertained in peripheral blood samples of patients who have this disease and in a group of patients who have a similar chronic lymphoproliferative conditions such as splenic marginal lymphoma. The finding of this specific mutation will help to verify or exclude the diagnosis of Hairy Cell Leukemia and determine whether patients are in remission.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    20 participants
    Observational Model:
    Other
    Time Perspective:
    Prospective
    Official Title:
    Assessment of the V600E Mutation in the B-RAF Gene in Chronic Lymphoproliferative Disease.
    Actual Study Start Date :
    Nov 1, 2012
    Actual Primary Completion Date :
    Mar 1, 2013
    Actual Study Completion Date :
    Apr 1, 2013

    Outcome Measures

    Primary Outcome Measures

    1. detection of the B-RAF V600E mutation [2 weeks]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    Patients over the age of 18 years -

    Exclusion Criteria:

    Patients less than 18 years in age or mentally defectives.

    -

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • HaEmek Medical Center, Israel

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    HaEmek Medical Center, Israel
    ClinicalTrials.gov Identifier:
    NCT01720758
    Other Study ID Numbers:
    • EMC-0124-11-CTIL
    First Posted:
    Nov 2, 2012
    Last Update Posted:
    Aug 11, 2017
    Last Verified:
    Aug 1, 2017
    Additional relevant MeSH terms:
    Lymphoma, B-Cell, Marginal Zone
    Leukemia, Hairy Cell
    Lymphoproliferative Disorders

    Study Results

    No Results Posted as of Aug 11, 2017