Factors Associated With Mortality, Morbidity and Prognosis in Dementia Patients

Sponsor
Gulhane Training and Research Hospital (Other)
Overall Status
Completed
CT.gov ID
NCT05052450
Collaborator
(none)
1,000
252

Study Details

Study Description

Brief Summary

Dementia; It is a chronic syndrome characterized by a general and progressive deterioration in cognition, including memory, orientation, language, and comprehension. The prognosis of this progressive and neurodegenerative disease after diagnosis may differ between individuals. In its broadest sense, the prognosis after a diagnosis of dementia; can be defined by shortening of life span, high level of cognitive and functional loss, decrease in quality of life and increased need for care. However, the prognosis of different types of dementia is highly variable. Because it is the most common type of dementia, studies are usually on Alzheimer's disease. It constitutes 50-75% of total dementia cases. Vascular dementia is the second most common cause of dementia and accounts for approximately 15% of dementia cases. Dementia with Lewy bodies constitutes 10-20% of the total dementia patients and ranks second among degenerative dementia types. Frontotemporal dementia, which mimics psychiatric disorders and has prominent behavioural problems, and Parkinson's disease-associated dementia, which is characterized by cognitive impairment that can be added to the existing picture in Parkinson's patients, are also counted among other types of dementia. Prognosis-related data on dementia types other than Alzheimer's disease are limited in the literature. Determining the prognosis is important to support patients, anticipate long-term health problems, plan physician and healthcare provision, and support patients with dementia.In view of the lack of sufficient data on dementia types other than Alzheimer's disease, it is aimed to contribute to the literature on this subject and to determine the factors that may affect prognosis, morbidity and mortality in patients belonging to all dementia types.

Condition or Disease Intervention/Treatment Phase
  • Other: Observational

Study Design

Study Type:
Observational
Actual Enrollment :
1000 participants
Observational Model:
Cohort
Time Perspective:
Retrospective
Official Title:
Factors Associated With Mortality, Morbidity and Prognosis in Dementia Patients
Actual Study Start Date :
Jan 1, 2000
Actual Primary Completion Date :
Dec 31, 2020
Actual Study Completion Date :
Dec 31, 2020

Arms and Interventions

Arm Intervention/Treatment
Dementia with Alzheimer

Patients previously diagnosed with Alzheimer disease would be included

Other: Observational
Patients data were collected throughout the following time

Dementia with Lewy Body Dementia

Patients previously diagnosed with Lewy Body Dementia would be included

Other: Observational
Patients data were collected throughout the following time

Dementia with Fronto-Temporal Dementia

Patients previously diagnosed with Fronto-Temporal Dementia would be included

Other: Observational
Patients data were collected throughout the following time

Dementia with Vascular Disease

Patients previously diagnosed with Dementia with Vascular Disease would be included

Other: Observational
Patients data were collected throughout the following time

Dementia with Parkinson Disease

Patients previously diagnosed with Dementia with Parkinson Disease would be included

Other: Observational
Patients data were collected throughout the following time

Outcome Measures

Primary Outcome Measures

  1. Mortality [2 years]

    The event of death occuring during the follow-up period

  2. Mini-Mental State Examination [2 years]

    It was performed to assess mental status. It gives an overall opinion on cognitive domains and tests orientation, registration, attention and calculation, recall, and language. Total scores on Mini-Mental State Examination range from 0 to 30, higher scores show better cognitive performance.

  3. Barthel Index [2 years]

    It was used for assessing physical functioning as a part of the routine geriatric evaluation.where the ten performance items used. Those items defined as feeding, bathing, grooming, dressing, continence of bowel and bladder, toilet use, transfers (bed to chair and back), mobility (on level surfaces), and climbing stairs. Each item is scored on this scale, and the sum is obtained by adding the score of each item (range, 0-100; higher scores show better performance)

Eligibility Criteria

Criteria

Ages Eligible for Study:
60 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

Having applied to the Gulhane Training and Research Hospital Geriatrics Polyclinic Being diagnosed with Alzheimer or Lewy Body Dementia or Vascular Dementia or Fronto-Temporal Dementia or Parkinson Disease Dementia Being at the age of 60 years or older

Exclusion Criteria:

Being under the age of 60 Patients with insufficient recorded data and follow-up for the study Patients who either have diagnosis or follow-up in another center. Patients who have severe dementia that prevents applying for outpatient clinic

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Gulhane Training and Research Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Neslihan Kayahan, Medical Doctor, Gulhane Training and Research Hospital
ClinicalTrials.gov Identifier:
NCT05052450
Other Study ID Numbers:
  • 2021/290
First Posted:
Sep 22, 2021
Last Update Posted:
Sep 22, 2021
Last Verified:
Sep 1, 2021
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Sep 22, 2021