Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University (Other)

Overall Status

Completed

CT.gov ID

NCT04984941

Collaborator

(none)

100

Enrollment

Location

Actual Duration (Months)

5.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity toDermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.

Condition or Disease	Intervention/Treatment	Phase
Asthma Allergic Rhinitis Conjunctivitis Atopic Dermatitis

Detailed Description

Background: The role of specific IgE (sIgE) against Der p 1and Der p 2 in Chinese patients with house dust mite (HDM)allergy has not yet been well investigated.Methods: One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity toDermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.

Study Design

Study Type:

Observational [Patient Registry]

Actual Enrollment :

100 participants

Observational Model:

Other

Time Perspective:

Cross-Sectional

Official Title:

Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients

Actual Study Start Date :

Mar 1, 2013

Actual Primary Completion Date :

Mar 1, 2014

Actual Study Completion Date :

Oct 1, 2014

Outcome Measures

Primary Outcome Measures

Demographic Characteristics [1 year]
Describe the patient's basic information in detail, including age, gender, family history, etc
Der p 1 Serum IgE [1 year]
Prevalence of Der p 1 Serum IgE in HDM-Allergic Patients
Der p 2 Serum IgE [1 year]
Prevalence of Der p 2 Serum IgE in HDM-Allergic Patients
Dp, Der p 1 and Der p 2 [1 year]
Relationship between Serum IgE Levels of Dp, Der p 1 and Der p 2
Factors associated with specific IgE against Der p 1 [1 year]
Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 1
Factors associated with specific IgE against Der p 2 [1 year]
Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 2
the Number of Affected Organs [1 year]
Association of Specific IgE Titers with the Number of Affected Organs

Eligibility Criteria

Criteria

Ages Eligible for Study:

3 Years to 60 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

HDM-allergic patients reporting allergic rhinitis, conjunctivitis, asthma and/or atopic dermatitis and who had never undergone immunotherapy, were enrolled if they were sensitized to Dp as judged by ImmunoCAP ( ≥ 1 kU/l) and/or skin reaction index (SRI)by skin-prick test (SPT, a wheal diameter ≥ 0.5 mm).