A Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
Study Details
Study Description
Brief Summary
This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of lebrikizumab in participants with asthma whose disease remains uncontrolled despite daily treatment with inhaled corticosteroid (ICS) therapy and at least one second controller medication. Participants will be randomized in 1:1:1 ratio to receive double-blind treatment with either lebrikizumab ("high" or "low") or placebo, administered subcutaneously (SC) every 4 weeks for 52 weeks, in addition to their standard-of-care therapy. This will be followed by a 52-week double-blind active treatment extension. During double-blind active treatment extension period, all participants will receive SC injection of lebrikizumab from Week 53 to Week 104. The anticipated time on study treatment is 104 weeks. After study treatment, all participants will complete a 20-week safety follow-up.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 3 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Lebrikizumab (125 mg) Participants will receive SC injection of lebrikizumab (125 milligrams [mg]) every 4 weeks for 104 weeks. |
Drug: Lebrikizumab
Lebrikizumab will be administered as SC injection at 125 or 37.5 mg every 4 weeks, for 104 weeks.
Other Names:
|
Experimental: Lebrikizumab (37.5 mg) Participants will receive SC injection of lebrikizumab (37.5 mg) every 4 weeks for 104 weeks. |
Drug: Lebrikizumab
Lebrikizumab will be administered as SC injection at 125 or 37.5 mg every 4 weeks, for 104 weeks.
Other Names:
Drug: Placebo
Lebrikizumab matching placebo will be administered as SC injection every 4 weeks for 52 weeks.
|
Placebo Comparator: Placebo Participants will receive SC injection of lebrikizumab matching placebo every 4 weeks for 52 weeks during placebo-controlled period and then SC injection of lebrikizumab at 125 or 37.5 mg for 52 weeks during active treatment extension period. |
Drug: Lebrikizumab
Lebrikizumab will be administered as SC injection at 125 or 37.5 mg every 4 weeks, for 104 weeks.
Other Names:
Drug: Placebo
Lebrikizumab matching placebo will be administered as SC injection every 4 weeks for 52 weeks.
|
Outcome Measures
Primary Outcome Measures
- Rate of Asthma Exacerbations During the 52-Week Placebo-Controlled Period [Baseline up to 52 weeks]
Secondary Outcome Measures
- Absolute Change From Baseline in Pre-Bronchodilator Forced Expiratory Volume in 1 Second (FEV1) [Baseline, Week 52]
- Time to First Asthma Exacerbation [Baseline up to 52 weeks]
- Change From Baseline in Standardized Asthma Quality of Life Questionnaire (AQLQ) Score [Baseline, Week 52]
- Change from Baseline In Asthma Rescue Medication (Number of Puffs or Nebulized Treatments) [Baseline, Week 52]
- Rate of Urgent Asthma-Related Urgent Health Care Utilization [Baseline up to Week 52]
- Percentage of Participants With Anti-Therapeutic Antibodies to Lebrikizumab [Baseline up to Week 124 (assessed at Baseline, Weeks 4, 12, 24, 36, 52, 64, 76, 92, 104, 112, and 124)]
- Change From Baseline in Asthma Control Questionnaire-5 (ACQ-5) Score [Baseline, Week 52]
- Percentage of Participants With Adverse Events [Baseline, Week 124]
- Minimum Serum Concentration (Cmin) of Lebrikizumab [Predose (0 hour) on Weeks 4, 12, 24, 36, and 52]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Asthma diagnosis for greater than equal to (>/=) 12 months prior to Visit 1
-
Bronchodilator response at Visit 1, 2, or 3
-
Pre-bronchodilator FEV1 of 40 percent (%) - 80% predicted at both Visits 2 and 3
-
On ICS therapy at a total daily dose of 500-2000 micrograms (mcg) of fluticasone propionate dry powder inhaler (DPI) or equivalent for >/=6 months prior to Visit 1
-
On an eligible second controller medication (long-acting beta-agonist [LABA], leukotriene receptor antagonist [LTRA], long-acting muscarinic antagonist [LAMA], or theophylline) for 6 months prior to Visit 1
-
Uncontrolled asthma at Visit 1 and/or Visit 2, and at Visit 3
-
Chest X-ray or computed tomography (CT) scan within 3 months prior to Visit 1 or chest X-ray during the screening period (prior to Visit 3) confirming the absence of other clinically significant lung disease
-
Demonstrated adherence with controller medication during the screening period
Exclusion Criteria:
-
History of severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the lebrikizumab injection
-
Maintenance oral corticosteroid therapy within 3 months of Visit 1
-
Treatment with systemic (oral, intravenous [IV], or intramuscular [IM]) corticosteroids within 4 weeks prior to Visit 1 or during the screening period
-
Treatment with intra-articular corticosteroids within 4 weeks prior to Visit 1 or during the screening period or anticipated need for intra-articular corticosteroids during the course of the study
-
Infection requiring hospital admission for >/=24 hours or requiring treatment with IV or IM antibiotics within 4 weeks prior to Visit 1 or during screening; Upper or lower respiratory tract infection within 4 weeks prior to Visit 1 or during screening; Active infection that required treatment with oral antibiotics within 2 weeks prior to Visit 1 or during screening; Active parasitic infection or Listeria monocytogenes infection within 6 months prior to Visit 1 or during screening
-
Active tuberculosis requiring treatment within 12 months prior to Visit 1
-
Known immunodeficiency, including, but not limited to, human immunodeficiency virus (HIV) infection
-
Evidence of acute or chronic hepatitis or known liver cirrhosis
-
History of interstitial lung disease, chronic obstructive pulmonary disease (COPD), or other clinically significant lung disease other than asthma
-
Known current malignancy or current evaluation for potential malignancy
-
Current smoker or former smoker with a history of greater than (>) 10 pack-years
-
History of alcohol or drug abuse
-
Past and/or current use of any anti-interleukin (IL)-13 or anti-IL-4/IL-13 therapy, including lebrikizumab
-
Use of other monoclonal antibody therapy, including omalizumab, within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) or during screening
-
Initiation of or change in allergen immunotherapy within 3 months prior to Visit 1 or during screening
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Alabama Clinical Research Associates | Pell City | Alabama | United States | 35128 |
2 | Clinical Trial Connection | Flagstaff | Arizona | United States | 86001 |
3 | Desert Sun Clinical Research LLC | Tucson | Arizona | United States | 85710 |
4 | Allianz Medical and Research Center | Fountain Valley | California | United States | 92708 |
5 | Allergy & Asthma Medical Group & Research Center, Pc | Long Beach | California | United States | 90808 |
6 | Alliance Research LLC | Long Beach | California | United States | 90813 |
7 | Allergy Medical Clinic | Los Angeles | California | United States | 90025 |
8 | CA Allergy & Asthma Med Grp | Los Angeles | California | United States | 90025 |
9 | North Bay Clinical Trials | Napa | California | United States | 94558 |
10 | Choc Psf, Amc | Orange | California | United States | 92868 |
11 | Advances in Medicine | Rancho Mirage | California | United States | 92270 |
12 | Allergy Assoc Medical Group | San Diego | California | United States | 92108 |
13 | UCSF School of Medicine | San Francisco | California | United States | |
14 | Bensch Research Associates | Stockton | California | United States | 95207 |
15 | IMMUNOe International Research Centers | Centennial | Colorado | United States | 80112 |
16 | Waterbury Pulmonary Associates | Waterbury | Connecticut | United States | 06708 |
17 | St. Francis Sleep; Allergy & Lung Institute | Clearwater | Florida | United States | 33765 |
18 | Creekside Medical Research | DeLand | Florida | United States | 32720 |
19 | Suncoast Research Group LLC | Miami | Florida | United States | 33135 |
20 | South Florida Research Phase I-IV, Inc | Miami | Florida | United States | 33165 |
21 | Allergy & Asthma Care of FL; Clinical Research | Ocala | Florida | United States | 34471 |
22 | Emerald Coast Research Associates | Panama City | Florida | United States | 32405 |
23 | Allergy & Asthma Diagnostic; Treatment Center | Tallahassee | Florida | United States | 32308 |
24 | Florida Pulmonary Research Institute, LLC | Winter Park | Florida | United States | 32789 |
25 | Southeastern Lung Care | Decatur | Georgia | United States | 30033 |
26 | Atlanta Allergy & Asthma Clini | Woodstock | Georgia | United States | 30188 |
27 | Laporte County Institute For Clinical Research | Michigan City | Indiana | United States | 46360 |
28 | Iowa Clinical Research Corporation | Iowa City | Iowa | United States | 52240 |
29 | Northeast Medical Research Associates, Inc | North Dartmouth | Massachusetts | United States | 02747 |
30 | Infusion Associates | Grand Rapids | Michigan | United States | 49525 |
31 | Midwest Clinical Research LLC | Saint Louis | Missouri | United States | 63141 |
32 | Washington Univ. School of Med | Saint Louis | Missouri | United States | 63141 |
33 | Montana Medical Research LLC | Missoula | Montana | United States | 59808 |
34 | Heartland Clinical Research Inc. | Omaha | Nebraska | United States | 68134 |
35 | Asthma & Allergy Center, P.C. | Papillion | Nebraska | United States | 68046 |
36 | Allergy & Asthma Associates | Las Vegas | Nevada | United States | 89104 |
37 | Allergy & Asthma Research of Nj, Inc | Mount Laurel | New Jersey | United States | 08054 |
38 | Atlantic Research Center, LLC | Ocean City | New Jersey | United States | 07712 |
39 | Princeton Center For Clinical Research | Skillman | New Jersey | United States | 08558 |
40 | North Shore University Hosp | New Hyde Park | New York | United States | 11042 |
41 | Montefiore Medical Center | The Bronx | New York | United States | 10461 |
42 | Allergy & Asthma Center of NC | High Point | North Carolina | United States | 27262 |
43 | PMG Research of Wilmington | Wilmington | North Carolina | United States | 28401 |
44 | Asthma & Allergy Center | Toledo | Ohio | United States | 43617 |
45 | Cor Clinical Research | Oklahoma City | Oklahoma | United States | 73103 |
46 | Lynn Health Science Institute | Oklahoma City | Oklahoma | United States | 73112 |
47 | Allergy & Asthma Research Grp | Eugene | Oregon | United States | 97401-7721 |
48 | Clinical Research Inst. of Southern Oregon, Pc | Medford | Oregon | United States | 97504 |
49 | Allergy Associates Research Center | Portland | Oregon | United States | 97202 |
50 | Central PA Asth & Allergy Care; Research Division | Altoona | Pennsylvania | United States | 16601 |
51 | Asthma Allergy Pulm Associates | Philadelphia | Pennsylvania | United States | 19107 |
52 | Grand View Hospital; Clinical Research Department | Sellersville | Pennsylvania | United States | 18960 |
53 | Asthma Allergy Phys of RI | Lincoln | Rhode Island | United States | 02865 |
54 | ADAC Research PA | Greenville | South Carolina | United States | 29607 |
55 | Spartanburg Medical Research | Spartanburg | South Carolina | United States | 29303 |
56 | Tekton Research Inc | Austin | Texas | United States | 78717 |
57 | TTS Research | Boerne | Texas | United States | 78006 |
58 | Pharmaceutical Research & Consulting, Inc. | Dallas | Texas | United States | 75231 |
59 | Allergy & Asthma Research Center of El Paso | El Paso | Texas | United States | 79925 |
60 | Pioneer Research Solutions | Houston | Texas | United States | 77008 |
61 | Metroplex Pulmonology & Sleep Center | McKinney | Texas | United States | 75069 |
62 | Quality Assurance Research Ctr | San Antonio | Texas | United States | 78205 |
63 | O & O Alpan, LLC | Fairfax | Virginia | United States | 22030 |
64 | Clinical Research Partners, LLC | Henrico | Virginia | United States | 23233 |
65 | Manassas Clinical Research Center | Manassas | Virginia | United States | 20110 |
66 | Bellingham Asthma, Allergy & Immunology | Bellingham | Washington | United States | 98225 |
67 | ASTHMA, Inc | Seattle | Washington | United States | 98105 |
68 | Marycliff Allergy Specialists | Spokane | Washington | United States | 99204 |
69 | Dean Clinic | Madison | Wisconsin | United States | 53715 |
70 | Fundación Faicep | Buenos Aires | Argentina | C1122AAK | |
71 | Centro Médico Dra de Salvo | Buenos Aires | Argentina | C1426ABP | |
72 | Instituto Ave Pulmo | Mar Del Plata | Argentina | CP 7600 | |
73 | Centro Respiratorio Quilmes | Quilmes | Argentina | 1878 | |
74 | Investigaciones en Patologias Respiratorias | San Miguel de Tucuman | Argentina | 4000 | |
75 | Liverpool Hospital | Liverpool BC | New South Wales | Australia | 1871 |
76 | St. Vincent's Hospital Melbourne | Fitzroy | South Australia | Australia | 3065 |
77 | Box Hill Hospital; Eastern Clinical Research Unit | Box Hill | Victoria | Australia | 3128 |
78 | Western Hospital | Footscray | Victoria | Australia | 3011 |
79 | The Lung Institute of Western Australia; Sir Charles Gairdner Hospital | Nedlands | Western Australia | Australia | 6009 |
80 | Cliniques Universitaires St-Luc | Bruxelles | Belgium | 1200 | |
81 | UZ Gent | Gent | Belgium | 9000 | |
82 | Alberta Health Services | Calgary | Alberta | Canada | T2N 4N2 |
83 | Dr. E. Amer | Mississauga | Ontario | Canada | L5M 2V8 |
84 | Inspiration Research Limited | Toronto | Ontario | Canada | M5T 3A9 |
85 | Albion Finch Medical Centre | Toronto | Ontario | Canada | M9V4B4 |
86 | Centre d'investigation Clinique Mauricie | Trois-Rivières | Quebec | Canada | G8T 7A1 |
87 | Centro de Investigaciones Medicas Respiratorias | Santiago | Chile | 7500692 | |
88 | Schonffeldt y Guerrero Limitada | Santiago | Chile | 7500698 | |
89 | Hospital Carlos Van Buren | Valparaiso | Chile | 2340000 | |
90 | Fundacion Neumologica Colombiana | Bogota DC | Colombia | 11001 | |
91 | Alergopraktik s.r.o. | Jablonec Nad Nisou | Czechia | 466 01 | |
92 | Interni A Pneumologicka Ambulance | Jindrichuv Hradec | Czechia | 377 38 | |
93 | MephaCentrum, a.s. | Ostrava - Poruba | Czechia | 708 68 | |
94 | Alergologie Teplice, s.r.o. | Teplice | Czechia | 415 01 | |
95 | Hopital Calmette; Pneumologie | Lille | France | 59037 | |
96 | Hopital Nord; CIC | Marseille | France | 13015 | |
97 | Hôpital Arnaud de Villeneuve | Montpellier | France | 34295 | |
98 | CHU Nantes - Hôpital Laennec; Service de Pneumologie | Nantes | France | 44093 | |
99 | Nouvel Hôpital Civil; Pôle de Pathologie Thoracique | Strabourg | France | 67091 | |
100 | Lungenarztpraxis Tegel | Berlin | Germany | 13507 | |
101 | Pneumologisches Zentrum Wiesloch | Wiesloch | Germany | 69168 | |
102 | Kenezy Korhaz Rendelointezet | Debrecen | Hungary | 4031 | |
103 | Petz Aladar Megyei Oktato Korhaz | Gyor | Hungary | 9024 | |
104 | C.C.C. Hospital Chest Diseases | Szeged | Hungary | 6722 | |
105 | Barzilai Medical Center; Pulmonary Inst. | Ashkelon | Israel | 78306 | |
106 | Lady Davis Carmel Medical Center; Cardiovascular Medicine | Haifa | Israel | 34362 | |
107 | Shaare Zedek Medical Center | Jerusalem | Israel | 91031 | |
108 | Meir Medical Center; Pulmonary Dept | Kfar Saba | Israel | 44281 | |
109 | Kaplan Medical Center | Rehovot | Israel | 7661041 | |
110 | University of Catanzaro | Catanzaro | Calabria | Italy | 88100 |
111 | Azienda Ospedaliero Universitaria di Parma | Parma | Emilia-Romagna | Italy | 43100 |
112 | Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi Di Ancona | Torrette - Ancona | Marche | Italy | 60100 |
113 | Fondazione Salvatore Maugeri. IRCCS - Divisione di Pneumologia | Cassano Murge (BA) | Puglia | Italy | 70020 |
114 | A.o. Universitaria Pisana; Dipartimento Cardio Toracico | Pisa | Toscana | Italy | 56100 |
115 | Azienda Ospedaliera di Padova | Padova | Veneto | Italy | 35128 |
116 | Tosei General Hospital; Respiratory and Allergy Medicine | Aichi | Japan | 489-8642 | |
117 | Ofuji Clinic | Amagasaki-shi | Japan | 660-0862 | |
118 | Kyushu Central Hospital | Fukuoka-shi | Japan | 815-8588 | |
119 | National Hospital Organization Mito Medical Center | Higashiibaraki-gun | Japan | 311-3193 | |
120 | Hiroshima University Hospital | Hiroshima | Japan | 734-8551 | |
121 | Oji General Hospital | Hokkaido | Japan | 053-8506 | |
122 | National Hospital Organization Asahikawa Medical Center | Hokkaido | Japan | 070-8644 | |
123 | Iwate Medical University Hospital | Iwate | Japan | 020-8505 | |
124 | Yokohama City Minato Red Cross Hospital | Kanagawa | Japan | 231-8682 | |
125 | National Hospital Organization Tokyo National Hospital | Kiyose-shi | Japan | 204-8585 | |
126 | Kochi Medical School Hospital | Kochi | Japan | 783-8505 | |
127 | Oki Clinic | Kodaira-shi | Japan | 187-0024 | |
128 | Takahashi Clinic | Kokubunji-shi | Japan | 185-0014 | |
129 | Dokkyo Medical University Koshigaya Hospital | Koshigaya-shi | Japan | 343-0845 | |
130 | Tono Chuo Clinic | Mizunami-shi | Japan | 509-6134 | |
131 | Nagaoka Red Cross Hospital | Nagaoka-shi | Japan | 940-2085 | |
132 | Niigata City General Hospital | Niigata-shi | Japan | 950-11977 | |
133 | Osaka City University Hospital | Osaka | Japan | 545-8586 | |
134 | Touda Clinic | Osaka | Japan | 589-0022 | |
135 | Kinki-Chuo Chest Medical Center | Osaka | Japan | 591-8555 | |
136 | Senzoku Kokyuuki and Allergy Clinic | Ota-ku | Japan | 145-0063 | |
137 | Japan Community Health Care Organization Hokkaido Hospital | Sapporo-shi | Japan | 062-8618 | |
138 | Fukuwa Clinic | Tokyo | Japan | 103-0027 | |
139 | Tokyo Center Clinic; Internal Medicine | Tokyo | Japan | 103-0028 | |
140 | Sano Toranomon Clinic | Tokyo | Japan | 105-0003 | |
141 | Showa University Hospital | Tokyo | Japan | 142-8666 | |
142 | Teikyo University Hospital | Tokyo | Japan | 173-8605 | |
143 | Sekino Hospital | Toshima | Japan | 171-0014 | |
144 | University of Fukui Hospital | Yoshida-gun | Japan | 910-1193 | |
145 | Seoul National University Bundang Hospital | Gyeonggi-do | Korea, Republic of | 13620 | |
146 | Asan Medical Center | Seoul | Korea, Republic of | 05505 | |
147 | Samsung Medical Center | Seoul | Korea, Republic of | 06351 | |
148 | Korea University Guro Hospital | Seoul | Korea, Republic of | 08308 | |
149 | St. Paul's Hospital, The Catholic University of Korea, College of Medicine | Seoul | Korea, Republic of | 130-709 | |
150 | Wonju Christian Hospital | Wonju | Korea, Republic of | 220-701 | |
151 | Instituto Jalisciense de Investigacion Clinica S.A. de C.V. | Guadalajara | Mexico | 44100 | |
152 | Hospital Dr Angel Leaño universidad Autonoma de Guadalajara AC | Zapopan | Mexico | 45200 | |
153 | NZ Respiratory & Sleep Institute | Auckland | New Zealand | 1051 | |
154 | Dunedin Hospital | Dunedin | New Zealand | ||
155 | RMC Medical Research Ltd | Dunedin | New Zealand | ||
156 | P3 Research | Tauranga | New Zealand | 3110 | |
157 | Centrum Medycyny Oddechowej Robert M. Mróz | Bialystok | Poland | 15-003 | |
158 | Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny | Bialystok | Poland | 15-430 | |
159 | Grazyna Pulka Specjalistyczny Ośrodek ALL-MED | Krakow | Poland | 31-023 | |
160 | Specjalistyczne Centrum Medyczne NOWOMED | Kraków | Poland | 30-349 | |
161 | Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k. | Kraków | Poland | 31-637 | |
162 | Poradnia Pulmonologiczna dla Doroslych | Lódz | Poland | 90-153 | |
163 | Centrum Alergologii Teresa Hofman | Poznan | Poland | 60-214 | |
164 | SPZOZ Proszowice | Proszowice | Poland | 32-100 | |
165 | Niepubliczny Specjalistyczny ZOZ Puls-Med s.c. | Skarżysko-Kamienna | Poland | 26-110 | |
166 | Medica Pro Familia Sp. z o.o. S.K.A. | Warszawa | Poland | 01-868 | |
167 | Klinika Chorób Wewnetrznych i Alergologii MSW | Warszawa | Poland | 02-507 | |
168 | ALL-MED Specjalistyczna Opieka Medyczna | Wroclaw | Poland | 50-445 | |
169 | Colentina Clinical Hospital | Bucharest | Romania | 020125 | |
170 | Prof.Dr.Octavian Fodor Emergency Clinical Hospital | Cluj-Napoca | Romania | 400162 | |
171 | Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Victor Babes Craiova | Craiova | Romania | 200515 | |
172 | Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital | Timisoara | Romania | 300310 | |
173 | SIH Kemerovo Regional Clinical Hospital | Kemerovo | Russian Federation | 650002 | |
174 | Russian Uni of People'S Friendship, Med. Faculty; City Clinical Hospital No 64, Internal Diseases | Moscow | Russian Federation | 117292 | |
175 | Central Clinical Hospital #1 of RZhD JCS | Moscow | Russian Federation | 125367 | |
176 | Novosibirsk Municipal Clinical Hospital For Emergency Medicine #2 | Novosibirsk | Russian Federation | 630008 | |
177 | Ryazan Regional Clinical Hosp | Ryazan | Russian Federation | 390039 | |
178 | St. George the Martyr City Hospital | Saint Petersburg | Russian Federation | ||
179 | St.-Petersburg SMU n. a. Academician I.P.Pavlov; Therapy Department | Saint-Petersburg | Russian Federation | 197022 | |
180 | Smolensk State Medical Academy | Smolensk | Russian Federation | 4812 | |
181 | City Outpatient Dept #94 | St Petersburg | Russian Federation | 193231 | |
182 | St-Petersburg Diagnostic Ctr#1; Pulmonology | St. Petersburg | Russian Federation | 194354 | |
183 | SHI Ctr Occupational Pathology | St. Petersburg | Russian Federation | 195271 | |
184 | St. Petersburg State Budget Medical Institution Pokrovskaya City Hospital | St. Petersburg | Russian Federation | 197022 | |
185 | Tomsk Regional Clinical Hospital | Tomsk | Russian Federation | 634063 | |
186 | Clinical Center of Serbia | Belgrade | Serbia | 11000 | |
187 | Clinical Hospital Center Zvezdara | Belgrade | Serbia | 11000 | |
188 | Clinical Hospital Center ''Bezanijska Kosa''; Department of Pulmology | Belgrade | Serbia | 11080 | |
189 | Alian s.r.o. | Bardejov | Slovakia | 08501 | |
190 | Tehelná Clinic, Inc; IMUNO-ALERGO, s. r.o. | Bratislava | Slovakia | 831 03 | |
191 | Plucna ambulancia | Spisska Nova Ves | Slovakia | 052 01 | |
192 | Melomed Hospital Gatesville | Cape Town | South Africa | 7764 | |
193 | Uni of Cape Town Lung Inst. | Cape Town | South Africa | 7925 | |
194 | Vawda Z.Fa Practice | Durban | South Africa | 4091 | |
195 | Gatesville Medical Centre | Gatesville | South Africa | 7746 | |
196 | Deepak Lakha MBCHB Private Practice | Johannesburg | South Africa | 1820 | |
197 | Botho ke Bontle Health Services | Pretoria | South Africa | 0101 | |
198 | Dr Johannes Breedt; Emmed Research | Pretoria | South Africa | 84 | |
199 | Hospital Universitario Araba | Vitoria | Alava | Spain | 01004 |
200 | Hospital de la Santa Creu; i Sant Pau | Barcelona | Spain | 08025 | |
201 | Hospital Germans Trias i Pujol | Barcelona | Spain | 08916 | |
202 | Hosp Univ Fundacion Alcorcon | Madrid | Spain | 28922 | |
203 | Hospital Virgen del Rocio | Sevilla | Spain | 41013 | |
204 | Hospital Universitario Doctor Peset | Valencia | Spain | 46017 | |
205 | Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi | Ankara | Turkey | 06290 | |
206 | Turgut Ozal Universitesi Tip Fakultesi Bestepe Hastanesi | Ankara | Turkey | 06510 | |
207 | Uludag University; Pulmonology and Allergy Department | Bursa | Turkey | 16059 | |
208 | Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi | Canakkale | Turkey | 17110 | |
209 | Ege University Medical Faculty | Izmir | Turkey | 35100 | |
210 | Izmir Dr. Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi | Izmir | Turkey | 35110 | |
211 | Kirikkale Universitesi Tip Fakultesi Hastanesi | Kirikkale | Turkey | 71100 | |
212 | Mersin University Medical Faculty | Mersin | Turkey | 33169 | |
213 | Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board | Dnepropetrovsk | Ukraine | 49000 | |
214 | Educational Scientific Medical Centre of Donetsk National Medical University; | Donetsk | Ukraine | 83003 | |
215 | Regional Phthisiology and Pulmonology Center | Ivano-Frankivsk | Ukraine | 76018 | |
216 | City Clinical Hospital #27 | Kharkiv | Ukraine | 61002 | |
217 | Medical and Sanitary Unit of OJSC "Kharkiv Tractor Plant n.a. Ordzhonikidze"; Department of Therapy | Kharkiv | Ukraine | 61007 | |
218 | Central Outpatient Hospital of Desnyansky District | Kyiv | Ukraine | 02232 | |
219 | Yanovskyy Inst of Phth. & Pulm; Clinical-functional | Kyiv | Ukraine | 03680 | |
220 | Municipal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital | Kyiv | Ukraine | 04107 | |
221 | Kyiv City Clinical Hospital #8 | Kyiv | Ukraine | 04201 | |
222 | Danylo Halytskyy National Medical University; Lviv | Lviv | Ukraine | 79010 | |
223 | Small Business Private Enterprise Medical Centre Pulse | Vinnytsya | Ukraine | 21001 | |
224 | Municipal Institution of Health Care "Yevpatoriya City Hospital №1 | Yevpatoriya | Ukraine | 97403 | |
225 | SI Dept. Clin. Hospital of Zaporizhzhia-2 Railway Station of SE Prydniprovska Zaliznytsia | Zaporizhzhia | Ukraine | 69104 | |
226 | St Peters Hospital | Chertsey | United Kingdom | KT16 0PZ | |
227 | Castle Hill Hospital; Respiratory Medicine | Cottingham | United Kingdom | HU16 5JQ | |
228 | Ninewells Hospital; Asthma and Allergy Research Group | Dundee | United Kingdom | DD1 9SY | |
229 | St James University Hospital; Respiratory Department | Leeds | United Kingdom | LS9 7TF | |
230 | University North Tees | Teesside | United Kingdom | TS27 |
Sponsors and Collaborators
- Hoffmann-La Roche
Investigators
- Study Director: Clinical Trials, Hoffmann-La Roche
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- GB28688
- 2013-000175-33