Effect of Physiological Ischemic Training on Patients With Atherosclerosis
Study Details
Study Description
Brief Summary
To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
No Intervention: Blank control group
|
|
Experimental: Exercise group
|
Behavioral: exercise
Upper limb resistance training with blood flow obstruction
|
No Intervention: Hyperlipidemia group
|
|
No Intervention: Hyperlipidemia and medication group
|
|
Experimental: Hyperlipidemia and exercise group
|
Behavioral: exercise
Upper limb resistance training with blood flow obstruction
|
Experimental: Hyperlipidemia and medication and exercise group
|
Behavioral: exercise
Upper limb resistance training with blood flow obstruction
|
No Intervention: Routine treatment group
|
|
Experimental: Routine treatment and exercise group
|
Behavioral: exercise
Upper limb resistance training with blood flow obstruction
|
Outcome Measures
Primary Outcome Measures
- Endothelium dependent vasodilation [8 weeks]
Percentage of the change
- Blood lipid analysis results [8 weeks]
Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein
Secondary Outcome Measures
- The inflammatory state [8 weeks]
Content of NO, eNOS, iNOS, IFN-γ, IL-6, IL-10 in blood
- Endothelial repair function [8 weeks]
eNOSmRNA, iNOSmRNA, EPCs in blood
Eligibility Criteria
Criteria
Inclusion Criteria:
-
LDL > 3.11mmol/l and less than 5.63mmol/l;
-
No serious heart, blood vessel and other related diseases;
-
There were no skeletal and muscular diseases affecting sports training;
-
No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time);
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Smoking less than 1 pack / year, no history of drinking.
Exclusion Criteria:
-
Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases;
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Pregnant women and people with disabilities;
-
Other circumstances determined by the researcher not suitable for the study.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Nanjing First Hospital | Nanjing | Jiangsu | China | 210006 |
Sponsors and Collaborators
- Nanjing First Hospital, Nanjing Medical University
Investigators
- Study Chair: Aicui Lin, PhD, Nanjing First Hospital, Nanjing Medical University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- KY20210604-02