AF-CAD: Atrial Fibrillation and Non-obstructive Coronary Lesions
Study Details
Study Description
Brief Summary
Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy. On the other hand, chronic coronary syndromes (CCS) remains the main cause of morbidity and mortality in an aging population. Both disease entities share common risk factors such as hypertension, diabetes and obesity The purpose of the study is to investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Atrial fibrillation (AF) and chronic coronary syndromes (CCS) share common risk factors and both disease entities frequently co-exist. Additionally, AF symptoms may mimic CCS. Objectives: To investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.
The prevalence of CCS in patients with AF varies from 17% to 47% whereas AF in patients with CCS is much less common, ranging from 0.2% to 5.Patients with AF more often have concomitant CCS as compared with sinus rhythm controls. Additionally, AF is more frequently present in patients with either peripheral- or cerebrovascular artery disease than in non-atherosclerotic individuals We conducted a multi-center retrospective study including consecutive patients referred for elective coronary angiography.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Patients underwent coronary angiography We reviewed medical notes of patients hospitalized for coronary angiography because of exacerbated angina (recurrent chest pain, classical stable angina, long history of chest pain/angina or other symptoms such as dyspnea). We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion. |
Procedure: Coronary angiography
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Outcome Measures
Primary Outcome Measures
- Coronary artery disease [Through study completion, an average of 8 years]
Number of Participants with significant findings on coronary angiography
Eligibility Criteria
Criteria
Inclusion Criteria:
- Coronary angiography
Exclusion Criteria:
- We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Medical Univeristy of Bialystok | Bialystok | Poland | 15-276 | |
2 | Department of Cardiology, Medical University of Bialystok, Bialystok, Poland | BiaĆystok | Poland | 15-276 | |
3 | Department of Cardiology and Internal Medicine, Medical University of Gdansk, Gdynia, Poland | Gdansk | Poland | 81-519 | |
4 | Department of Internal diseases, I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation | Moscow | Russian Federation | 119991 | |
5 | iverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom | Liverpool | United Kingdom | L69 7TX |
Sponsors and Collaborators
- Medical University of Bialystok
- I.M. Sechenov First Moscow State Medical University
- Liverpool Heart and Chest Hospital NHS Foundation Trust
- Medical University of Gdansk
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- UMB-KKI-102