AF-CAD: Atrial Fibrillation and Non-obstructive Coronary Lesions

Sponsor
Medical University of Bialystok (Other)
Overall Status
Completed
CT.gov ID
NCT04537507
Collaborator
I.M. Sechenov First Moscow State Medical University (Other), Liverpool Heart and Chest Hospital NHS Foundation Trust (Other), Medical University of Gdansk (Other)
8,000
5
144
1600
11.1

Study Details

Study Description

Brief Summary

Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with excessive risk of ischemic stroke and heart failure as well as reduced life expectancy. On the other hand, chronic coronary syndromes (CCS) remains the main cause of morbidity and mortality in an aging population. Both disease entities share common risk factors such as hypertension, diabetes and obesity The purpose of the study is to investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

Condition or Disease Intervention/Treatment Phase
  • Procedure: Coronary angiography

Detailed Description

Atrial fibrillation (AF) and chronic coronary syndromes (CCS) share common risk factors and both disease entities frequently co-exist. Additionally, AF symptoms may mimic CCS. Objectives: To investigate the hypothesis indicating lack of significant coronary lesions in AF vs. sinus rhythm (SR) patients.

The prevalence of CCS in patients with AF varies from 17% to 47% whereas AF in patients with CCS is much less common, ranging from 0.2% to 5.Patients with AF more often have concomitant CCS as compared with sinus rhythm controls. Additionally, AF is more frequently present in patients with either peripheral- or cerebrovascular artery disease than in non-atherosclerotic individuals We conducted a multi-center retrospective study including consecutive patients referred for elective coronary angiography.

Study Design

Study Type:
Observational
Actual Enrollment :
8000 participants
Observational Model:
Cohort
Time Perspective:
Other
Official Title:
Is Atrial Fibrillation is Associated With Non-significant Coronary Angiography Findings?
Actual Study Start Date :
Jan 1, 2010
Actual Primary Completion Date :
Dec 1, 2021
Actual Study Completion Date :
Jan 1, 2022

Arms and Interventions

Arm Intervention/Treatment
Patients underwent coronary angiography

We reviewed medical notes of patients hospitalized for coronary angiography because of exacerbated angina (recurrent chest pain, classical stable angina, long history of chest pain/angina or other symptoms such as dyspnea). We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion.

Procedure: Coronary angiography

Outcome Measures

Primary Outcome Measures

  1. Coronary artery disease [Through study completion, an average of 8 years]

    Number of Participants with significant findings on coronary angiography

Eligibility Criteria

Criteria

Ages Eligible for Study:
N/A and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • Coronary angiography
Exclusion Criteria:
  • We excluded patients with acute coronary syndromes (ACS), Tako-tsubo cardiomiopathy and history of ischemic heart disease, as well as those referred for coronary angiography before heart valve surgery. Prior cardiosurgical valve replacement was also the exclusion criterion.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Medical Univeristy of Bialystok Bialystok Poland 15-276
2 Department of Cardiology, Medical University of Bialystok, Bialystok, Poland BiaƂystok Poland 15-276
3 Department of Cardiology and Internal Medicine, Medical University of Gdansk, Gdynia, Poland Gdansk Poland 81-519
4 Department of Internal diseases, I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation Moscow Russian Federation 119991
5 iverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom Liverpool United Kingdom L69 7TX

Sponsors and Collaborators

  • Medical University of Bialystok
  • I.M. Sechenov First Moscow State Medical University
  • Liverpool Heart and Chest Hospital NHS Foundation Trust
  • Medical University of Gdansk

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Lukasz Kuzma, Principal Investigator, Medical University of Bialystok
ClinicalTrials.gov Identifier:
NCT04537507
Other Study ID Numbers:
  • UMB-KKI-102
First Posted:
Sep 3, 2020
Last Update Posted:
Jan 10, 2022
Last Verified:
Sep 1, 2021
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Lukasz Kuzma, Principal Investigator, Medical University of Bialystok
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jan 10, 2022