Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus
Study Details
Study Description
Brief Summary
Lichen planus (LP) is a common chronic inflammatory mucocutaneous disease with an immunologic etiology ,which has number of different clinical forms. Alternative natural or herbal origine drugs with antioxidant and anti-inflammatory properties have been used individually or in combination with systemic corticosteroids in order to decrease adverse drug reactions.
This study was conducted to evaluate the effect of quercetin on treatment of erosive -atrophic lesions of oral lichen planus (OLP).
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Phase 1 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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Active Comparator: quercetin quercetin is one of flavonoids , and having therapeutical anti-inflammatory and antioxidant action |
Drug: Quercetin
The patient is directed to digest quercetin hydrate capsule two times a day,until one mouth
|
Placebo Comparator: placebo placebo capsul is produced with lactose for using in placebo/ control group. |
Drug: placebo
The patient is directed to use placebo capsule two times a day, ,until the one mouth
|
Outcome Measures
Primary Outcome Measures
- the effects of this Drug on OLP measured with VAS scale for pain and evaluation of intensity of lesions. [2 months]
In the present work the Analogical Visual Scale is used TO evaluate pain,and we also record the intensity of lesions weekly and any side effect of this Drug
Eligibility Criteria
Criteria
Inclusion Criteria:
-
confirmation of clinical diagnosis of Atrophic and erosive lichen planus by histological examination
-
two weeks wash out periods after the last treatment
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having the experience of atrophic and erosive lesion greater than 1 cm having the experience of pain and burning greater than 3.5 in VAS Score
Exclusion Criteria:
-
confirmation of dysplasia and malignancy in histologic examination
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confirmation of lichenoid reaction in histologic examination
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pregnancy and breast feeding
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using fluorokinolon and cyclosporin which interact with quercetin
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Mashhad university of Medical science, Research Center of oral and maxillofacial medicine | Mashhad | Khorasan Razavi | Iran, Islamic Republic of | 91735 |
Sponsors and Collaborators
- Mashhad University of Medical Sciences
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 88705