Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT03375320
Collaborator
(none)
395
426
2
86.5
0.9
0

Study Details

Study Description

Brief Summary

This randomized phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that have spread to other places in the body (advanced). Cabozantinib is a chemotherapy drug known as a tyrosine kinase inhibitor, and it targets specific tyrosine kinase receptors, that when blocked, may slow tumor growth.

Detailed Description

PRIMARY OBJECTIVES:
  1. To determine whether cabozantinib S-malate (cabozantinib) can significantly improve progression-free survival (PFS) compared to placebo in patients with advanced pancreatic neuroendocrine tumors (NET) whose disease has progressed after prior therapy.

  2. To determine whether cabozantinib can significantly improve progression-free survival (PFS) compared to placebo in patients with advanced carcinoid tumors whose disease has progressed after prior therapy.

SECONDARY OBJECTIVES:
  1. To determine whether cabozantinib can significantly improve overall survival (OS) compared to placebo in patients with advanced pancreatic NET whose disease has progressed after prior therapy.

  2. To determine whether cabozantinib can significantly improve overall survival (OS) compared to placebo in patients with advanced carcinoid tumors whose disease has progressed after prior therapy.

  3. To evaluate safety and tolerability of cabozantinib versus placebo in patients with advanced pancreatic NET using Common Terminology Criteria for Adverse Events (CTCAE) and Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).

  4. To evaluate safety and tolerability of cabozantinib versus placebo in patients with advanced carcinoid tumors using CTCAE and PRO-CTCAE.

  5. To evaluate the overall radiographic response rate of cabozantinib versus placebo in patients with advanced pancreatic NET whose disease has progressed after prior therapy.

  6. To evaluate the overall radiographic response rate of cabozantinib versus placebo in patients with advanced carcinoid tumors whose disease has progressed after prior therapy.

OTHER OBJECTIVES:
  1. Results of the primary analysis will be examined for consistency, while taking into account the stratification factors and/or covariates of baseline quality of life (QOL) and fatigue.
QUALITY OF LIFE SUBSTUDY OBJECTIVES:
  1. To compare overall quality of life, disease-related symptoms, and other domains between the two treatment groups (cabozantinib versus [vs.] placebo) within each cohort of patients (pancreatic NET vs. carcinoid tumor). (Quality of Life Substudy Objective - A021602-HO1)
POPULATION PHARMACOKINETICS SUBSTUDY OBJECTIVES:
  1. To describe the population pharmacokinetic and exposure-response relationships of cabozantinib in patients with advanced neuroendocrine tumors.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive cabozantinib S-malate orally (PO) once daily (QD) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 12 weeks until disease progression or start of new anticancer therapy, and then every 6 months until 8 years after registration.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
395 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Double (Participant, Investigator)
Primary Purpose:
Treatment
Official Title:
Randomized, Double-Blinded Phase III Study of Cabozantinib Versus Placebo in Patients With Advanced Neuroendocrine Tumors After Progression on Prior Therapy (CABINET)
Actual Study Start Date :
Jul 18, 2018
Anticipated Primary Completion Date :
Oct 1, 2025
Anticipated Study Completion Date :
Oct 1, 2025

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm I (cabozantinib S-malate)

Patients receive cabozantinib S-malate PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Drug: Cabozantinib S-malate
Given PO
Other Names:
  • BMS-907351
  • Cabometyx
  • Cometriq
  • XL-184
  • XL184
  • Other: Laboratory Biomarker Analysis
    Correlative studies

    Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment
  • Placebo Comparator: Arm II (placebo)

    Patients receive placebo PO QD on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

    Other: Laboratory Biomarker Analysis
    Correlative studies

    Other: Placebo Administration
    Given PO

    Other: Quality-of-Life Assessment
    Ancillary studies
    Other Names:
  • Quality of Life Assessment
  • Outcome Measures

    Primary Outcome Measures

    1. Progression-free survival (PFS) [From randomization to the first radiographic documentation of disease progression, or death from any cause, assessed for up to 8 years]

      Will be assessed per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 determined by retrospective independent central review. Will be compared between treatment arms using the stratified log rank test at one-sided level 0.025. The stratification factors will be used for the analysis. The hazard ratio (HR) for PFS will be estimated using a stratified Cox proportional hazards model, and the 95% confidence interval (CI) for the HR will be provided. Results from an unstratified analysis will also be provided. Kaplan-Meier methodology will be used to estimate the median PFS for each treatment arm, and Kaplan-Meier curves will be produced. Brookmeyer Crowley methodology will be used to construct the 95% CI for the median PFS for each treatment arm.

    Secondary Outcome Measures

    1. Overall survival (OS) [From randomization to death, from any cause, assessed for up to 8 years]

      The analyses for OS will follow intent-to-treat (ITT) principle and will be conducted separately within each cohort (pancreatic neuroendocrine tumor [NET] and carcinoid tumor). The distribution of OS will be estimated using the method of Kaplan-Meier. The median OS, along with the 95% CI, will be estimated by the two treatment groups. Overall survival will be compared between treatment arms using the stratified log-rank test at a one-sided cumulative 2.5% level of significance. The stratified Cox regression will be used to estimate the HR of OS, along with the 95% CI. A hierarchical approach will be used to control for family-wise type-I error rate, therefore OS will be formally statistically tested only if the primary efficacy endpoint, PFS, is statistically significantly different between the two treatment groups.

    2. Incidence of adverse events (AEs) graded according to the Common Terminology Criteria for Adverse Events (CTCAE) and Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) [Up to 8 years]

      For CTCAE data, the frequency tables will be reviewed to determine the patterns. The overall adverse event rates will be compared between treatment groups using Chi-square test (or Fisher's exact test if the data in contingency table is sparse). PRO-CTCAE data will, at minimum, be analyzed similarly to CTCAE data. The initial analysis of each PRO-CTCAE item will use all available scores in an analysis which mirrors the approach used for the CTCAE data. Supplemental analysis will use model-based multiple imputation incorporating baseline patient characteristics and physician-rated performance status. CTCAE data may be incorporated as auxiliary data into multiple imputation models for AEs which are captured by both PRO-CTCAE and CTCAE. Results from supplemental analysis will be descriptively compared to the results of the initial analysis to assess the robustness of results to missing data. Additional analyses of PRO-CTCAE data beyond those specified above may be undertaken.

    3. Radiographic response rate [Up to 8 years]

      Will be defined as the proportion of patients in each arm whose best response is either complete response (CR) or partial response (PR). Radiographic response rate for both cohorts: the analyses for radiographic response rate will follow the ITT principle and will be conducted separately within each cohort (pancreatic NET and carcinoid tumor). The proportion of patients with either CR or PR as their best response will be estimated using point estimates and 95% confidence intervals according to the methods in Duffy and Santner. Radiographic response rate will be compared between treatment arms using the 2-sample z-test to compare sample proportion at a one-sided 2.5% level of significance.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Documentation of Disease:

    • Histologic Documentation: Well- or moderately-differentiated neuroendocrine tumors of pancreatic and non-pancreatic (i.e. carcinoid) origin by local pathology

    • The pathology report must state ONE of the following: 1) well- or moderately-differentiated neuroendocrine tumor, 2) low- or intermediate-grade neuroendocrine tumor, or 3) carcinoid tumor or atypical carcinoid tumor; documentation of histology from a primary or metastatic site is allowed

    • Patients with poorly differentiated neuroendocrine carcinoma, high-grade neuroendocrine carcinoma, adenocarcinoid tumor, or goblet cell carcinoid tumor are not eligible

    • Stage: Locally advanced/unresectable or metastatic disease

    • Tumor Site: Histological documentation of neuroendocrine tumor of pancreatic, gastrointestinal (GI), lung, or unknown primary site; GI, lung, and unknown primary NETs will enroll in the carcinoid tumor cohort of the study

    • Functional (associated with a clinical hormone syndrome) or nonfunctional tumors are allowed

    • Radiologic Evaluation: Target lesions must have shown evidence of disease progression by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 criteria in the 12 months prior to registration; the radiologic images, imaging reports, and clinic notes indicating growth of existing lesions, development of new lesions, or treatment changes must be submitted

    • Measurable Disease

    • Patients must have measurable disease per RECIST 1.1 by computer tomography (CT) scan or magnetic resonance imaging (MRI)

    • Lesions must be accurately measured in at least one dimension (longest diameter to be recorded) as >= 1 cm with CT or MRI (or >= 1.5 cm for lymph nodes); non-measurable disease includes disease smaller than these dimensions or lesions considered truly non-measurable including: leptomeningeal disease, ascites, pleural or pericardial effusion, lymphangitic involvement of skin or lung

    • Prior Treatment

    • Patient must have experienced disease progression on or intolerance to treatment discontinuation of at least one Food and Drug Administration (FDA)-approved line of therapy (except somatostatin analogs); prior lins of therapy may include: everolimus, sunitinib, or lutetium Lu 177 dotatate in patients with pancreatic NET; everolimus in patients with lung NET; everolimus or lutetium Lu 177 dotatate in patients with gastrointestinal NET

    • Prior treatment (except somatostatin analogs) with biologic therapy, immunotherapy, chemotherapy, investigational agent for malignancy, and/or radiation must be completed at least 28 days prior to registration

    • Prior treatment with somatostatin analogs is allowed, and continuation of treatment with somatostatin analogs while on cabozantinib/placebo is allowed provided that the patient has been on a stable dose for at least two months

    • Prior systemic treatment with radionuclide therapy must be completed at least 6 weeks prior to registration

    • Prior treatment with hepatic artery embolization (including bland embolization, chemoembolization, and selective internal radiation therapy) or ablative therapies is allowed if measurable disease remains outside of the treated area or if there is documented disease progression in a treated site; prior liver-directed or other ablative treatment must be completed at least 28 days prior to registration

    • Prior treatment with cabozantinib is not allowed

    • Patients should have resolution of any toxic effects of prior therapy (except alopecia and fatigue) to National Cancer Institute (NCI) CTCAE, version 5.0, grade 1 or less

    • Patients must have completed any major surgery at least 12 weeks prior to registration and any minor surgery (including uncomplicated tooth extractions) at least 28 days prior to registration; complete wound healing from major surgery must have occurred at least 28 days prior to registration, and complete wound healing from minor surgery must have occurred at least 10 days prior to registration

    • Patient History

    • No class III or IV congestive heart failure (CHF) within 6 months of registration

    • No clinically significant cardiac arrhythmia within 6 months of registration

    • No unstable angina or MI within 6 months of registration

    • No thromboembolic events within 6 months of registration (including [incl.] stroke, transient ischemic attack [TIA], deep vein thrombosis [DVT], & pulmonary embolism [PE])

    • No known history of congenital long QT syndrome

    • No uncontrolled hypertension within 14 days of registration (defined as systolic blood pressure [SBP] >= 150 mmHg and/or diastolic blood pressure [DBP] >= 90 mmHg despite optimal medical management)

    • No clinically significant GI bleeding within 6 months of registration

    • No clinically significant gastrointestinal abnormalities that may increase the risk for gastrointestinal bleeding within 6 months of registration including, but not limited to: active peptic ulcer, known endoluminal metastatic lesion(s) with history of bleeding, inflammatory bowel disease, or other gastrointestinal conditions with increased risk of perforation

    • No GI perforation within 6 months of registration

    • No known tumor with invasion into the GI tract from the outside causing increased risk of perforation or bleeding within 28 days of registration

    • No radiologic or clinical evidence of pancreatitis

    • No known cavitary lung lesions

    • No known endobronchial lesions involving the main or lobar bronchi and/or lesions infiltrating major pulmonary vessels that increase the risk of pulmonary hemorrhage; (CT with contrast is recommended to evaluate such lesions)

    • No hemoptysis greater than 1/2 teaspoon (2.5 mL) or any other signs of pulmonary hemorrhage within the 3 months prior to registration

    • No known tumor invading or encasing any major blood vessels

    • No history of non-healing wounds or ulcers within 28 days of registration

    • No history of fracture within 28 days of registration

    • No brain metastases or cranial epidural disease unless adequately treated, stable, and off steroid support for at least 4 weeks prior to registration

    • No known medical condition causing an inability to swallow oral formulations of agents

    • No history of allergic reaction attributed to compounds of similar chemical or biological composition to cabozantinib/placebo

    • No "currently active" second malignancy other than non-melanoma skin cancers or cervical carcinoma in situ; patients are not considered to have a "currently active" malignancy if they have completed therapy and are free of disease for >= 3 years

    • Concomitant Medications

    • Other planned concurrent investigational agents or other tumor directed therapies (chemotherapy, radiation) are not allowed while on this study

    • Concurrent use of somatostatin analogs while on cabozantinib/placebo is allowed provided that the patient has been on a stable dose for at least two months

    • Full dose oral anticoagulation/antiplatelet therapy is not permitted; low dose aspirin =< 81 mg/day is allowed; anticoagulation with therapeutic doses of low molecular weight heparin (LMWH) is allowed in patients who are on a stable dose of LMWH for at least 6 weeks prior to registration; treatment with warfarin is not allowed; anticoagulation in patients with brain metastases is not permitted

    • Chronic concomitant treatment with strong inhibitors of CYP3A4 is not allowed; patients must discontinue the drug at least 14 days prior to registration on the study

    • Chronic concomitant treatment with strong CYP3A4 inducers is not allowed; patients must discontinue the drug at least 14 days prior to the start of study treatment

    • Not pregnant and not nursing

    • Women of childbearing potential must have a negative pregnancy test done =< 14 days prior to registration

    • A female of childbearing potential is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months (i.e. has had menses at any time in the preceding 12 consecutive months)

    • Eastern Cooperative Oncology Group (ECOG) performance status: 0-2

    • Absolute neutrophil count (ANC) >= 1,500/mm^3

    • Hemoglobin >= 9 g/dL

    • Platelet count >= 100,000/mm^3

    • Prothrombin time (PT)/ international normalized ratio (INR), partial thromboplastin time (PTT) < 1.3 x upper limit of normal (ULN)

    • Aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) =< 3 x ULN

    • Total bilirubin =< 1.5 x ULN

    • Except in the case of Gilbert disease, in which case total bilirubin must be =< 3 x ULN

    • Creatinine =< 1.5 mg/dL OR creatinine clearance >= 45 mL/min

    • Albumin >= 2.8 g/dL

    • Potassium within normal limits (WNL)

    • Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible

    • Phosphorus WNL

    • Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible

    • Calcium WNL Phosphorus WNL

    • Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible

    • Magnesium WNL

    • Supplementation is acceptable to achieve a value WNL; in patients with low albumin levels, a corrected calcium value WNL is acceptable; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible

    • Urine protein to creatinine (UPC) ratio =< 1

    • QT interval corrected for heart rate using Fridericia's formula (QTcF) =< 500 msec

    • Thyroid-stimulating hormone (TSH) WNL

    • Supplementation is acceptable to achieve a TSH WNL; in patients with abnormal TSH, if free T4 is normal and patient is clinically euthyroid, patient is eligible

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Katmai Oncology Group Anchorage Alaska United States 99508
    2 Kingman Regional Medical Center Kingman Arizona United States 86401
    3 Banner University Medical Center - Tucson Tucson Arizona United States 85719
    4 University of Arizona Cancer Center-North Campus Tucson Arizona United States 85719
    5 University of Arkansas for Medical Sciences Little Rock Arkansas United States 72205
    6 Kaiser Permanente-Deer Valley Medical Center Antioch California United States 94531
    7 PCR Oncology Arroyo Grande California United States 93420
    8 Sutter Auburn Faith Hospital Auburn California United States 95602
    9 Alta Bates Summit Medical Center-Herrick Campus Berkeley California United States 94704
    10 Mills-Peninsula Medical Center Burlingame California United States 94010
    11 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    12 Epic Care-Dublin Dublin California United States 94568
    13 Epic Care Partners in Cancer Care Emeryville California United States 94608
    14 Kaiser Permanente-Fremont Fremont California United States 94538
    15 Palo Alto Medical Foundation-Fremont Fremont California United States 94538
    16 Kaiser Permanente-Fresno Fresno California United States 93720
    17 Contra Costa Regional Medical Center Martinez California United States 94553-3156
    18 Fremont - Rideout Cancer Center Marysville California United States 95901
    19 Memorial Medical Center Modesto California United States 95355
    20 Kaiser Permanente-Modesto Modesto California United States 95356
    21 Palo Alto Medical Foundation-Camino Division Mountain View California United States 94040
    22 Alta Bates Summit Medical Center - Summit Campus Oakland California United States 94609
    23 Kaiser Permanente-Oakland Oakland California United States 94611
    24 Palo Alto Medical Foundation Health Care Palo Alto California United States 94301
    25 Stanford Cancer Institute Palo Alto Palo Alto California United States 94304
    26 Kaiser Permanente-Redwood City Redwood City California United States 94063
    27 Kaiser Permanente-Richmond Richmond California United States 94801
    28 Kaiser Permanente-Roseville Roseville California United States 95661
    29 Sutter Roseville Medical Center Roseville California United States 95661
    30 Kaiser Permanente Downtown Commons Sacramento California United States 95814
    31 Sutter Medical Center Sacramento Sacramento California United States 95816
    32 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
    33 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    34 Salinas Valley Memorial Salinas California United States 93901
    35 California Pacific Medical Center-Pacific Campus San Francisco California United States 94115
    36 Kaiser Permanente-San Francisco San Francisco California United States 94115
    37 UCSF Medical Center-Mission Bay San Francisco California United States 94158
    38 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    39 Kaiser Permanente San Leandro San Leandro California United States 94577
    40 Mills Health Center San Mateo California United States 94401
    41 Kaiser Permanente-San Rafael San Rafael California United States 94903
    42 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    43 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    44 Palo Alto Medical Foundation-Santa Cruz Santa Cruz California United States 95065
    45 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
    46 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    47 Kaiser Permanente-Stockton Stockton California United States 95210
    48 Palo Alto Medical Foundation-Sunnyvale Sunnyvale California United States 94086
    49 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    50 Kaiser Permanente-Vallejo Vallejo California United States 94589
    51 Sutter Solano Medical Center/Cancer Center Vallejo California United States 94589
    52 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    53 Rocky Mountain Cancer Centers-Aurora Aurora Colorado United States 80012
    54 Rocky Mountain Cancer Centers-Boulder Boulder Colorado United States 80304
    55 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    56 National Jewish Health-Main Campus Denver Colorado United States 80206
    57 Rocky Mountain Cancer Centers-Midtown Denver Colorado United States 80218
    58 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    59 Rocky Mountain Cancer Centers-Rose Denver Colorado United States 80220
    60 Mountain Blue Cancer Care Center - Swedish Englewood Colorado United States 80113
    61 Swedish Medical Center Englewood Colorado United States 80113
    62 National Jewish Health-Western Hematology Oncology Golden Colorado United States 80401
    63 Saint Mary's Hospital and Regional Medical Center Grand Junction Colorado United States 81501
    64 North Colorado Medical Center Greeley Colorado United States 80631
    65 Good Samaritan Medical Center Lafayette Colorado United States 80026
    66 Rocky Mountain Cancer Centers-Littleton Littleton Colorado United States 80120
    67 Rocky Mountain Cancer Centers-Sky Ridge Lone Tree Colorado United States 80124
    68 McKee Medical Center Loveland Colorado United States 80539
    69 National Jewish Health-Northern Hematology Oncology Thornton Colorado United States 80260
    70 SCL Health Lutheran Medical Center Wheat Ridge Colorado United States 80033
    71 Danbury Hospital Danbury Connecticut United States 06810
    72 Norwalk Hospital Norwalk Connecticut United States 06856
    73 MedStar Georgetown University Hospital Washington District of Columbia United States 20007
    74 GenesisCare USA - Aventura FP Aventura Florida United States 33180
    75 GenesisCare USA - Aventura Aventura Florida United States 33180
    76 GenesisCare USA - Boca Ration FP06 Boca Raton Florida United States 33431
    77 Regional Cancer Center-Lee Memorial Health System Fort Myers Florida United States 33905
    78 Memorial Regional Hospital/Joe DiMaggio Children's Hospital Hollywood Florida United States 33021
    79 Moffitt Cancer Center Tampa Florida United States 33612
    80 Emory University Hospital Midtown Atlanta Georgia United States 30308
    81 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    82 Emory Saint Joseph's Hospital Atlanta Georgia United States 30342
    83 Hawaii Cancer Care - Savio 'Aiea Hawaii United States 96701
    84 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    85 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    86 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    87 Queen's Medical Center Honolulu Hawaii United States 96813
    88 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    89 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    90 Kaiser Permanente Moanalua Medical Center Honolulu Hawaii United States 96819
    91 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    92 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    93 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    94 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    95 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    96 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    97 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    98 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    99 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    100 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    101 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    102 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    103 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    104 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    105 Illinois CancerCare-Canton Canton Illinois United States 61520
    106 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    107 University of Illinois Chicago Illinois United States 60612
    108 University of Chicago Comprehensive Cancer Center Chicago Illinois United States 60637
    109 Carle on Vermilion Danville Illinois United States 61832
    110 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    111 Illinois CancerCare-Dixon Dixon Illinois United States 61021
    112 Carle Physician Group-Effingham Effingham Illinois United States 62401
    113 Crossroads Cancer Center Effingham Illinois United States 62401
    114 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    115 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    116 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    117 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    118 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    119 Loyola University Medical Center Maywood Illinois United States 60153
    120 UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois United States 60451
    121 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    122 University of Chicago Medicine-Orland Park Orland Park Illinois United States 60462
    123 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    124 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    125 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    126 Illinois CancerCare-Peru Peru Illinois United States 61354
    127 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    128 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    129 Springfield Clinic Springfield Illinois United States 62702
    130 Carle Cancer Center Urbana Illinois United States 61801
    131 Illinois CancerCare - Washington Washington Illinois United States 61571
    132 Memorial Hospital of South Bend South Bend Indiana United States 46601
    133 University of Iowa Healthcare Cancer Services Quad Cities Bettendorf Iowa United States 52722
    134 Mercy Hospital Cedar Rapids Iowa United States 52403
    135 Oncology Associates at Mercy Medical Center Cedar Rapids Iowa United States 52403
    136 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    137 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    138 Greater Regional Medical Center Creston Iowa United States 50801
    139 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    140 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    141 Broadlawns Medical Center Des Moines Iowa United States 50314
    142 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    143 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    144 Trinity Regional Medical Center Fort Dodge Iowa United States 50501
    145 University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa United States 52242
    146 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    147 University of Kentucky/Markey Cancer Center Lexington Kentucky United States 40536
    148 LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana United States 70805
    149 Our Lady of The Lake Baton Rouge Louisiana United States 70808
    150 Louisiana Hematology Oncology Associates LLC Baton Rouge Louisiana United States 70809
    151 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
    152 Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana United States 70809
    153 Northshore Oncology Associates-Covington Covington Louisiana United States 70433
    154 Oncology Center of The South Incorporated Houma Louisiana United States 70360
    155 Brigham and Women's Hospital Boston Massachusetts United States 02115
    156 Boston Medical Center Boston Massachusetts United States 02118
    157 Beth Israel Deaconess Medical Center Boston Massachusetts United States 02215
    158 Dana-Farber Cancer Institute Boston Massachusetts United States 02215
    159 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    160 Hickman Cancer Center Adrian Michigan United States 49221
    161 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    162 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    163 Bronson Battle Creek Battle Creek Michigan United States 49017
    164 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    165 Trinity Health IHA Medical Group Hematology Oncology - Brighton Brighton Michigan United States 48114
    166 Saint Joseph Mercy Canton Canton Michigan United States 48188
    167 Trinity Health IHA Medical Group Hematology Oncology - Canton Canton Michigan United States 48188
    168 Caro Cancer Center Caro Michigan United States 48723
    169 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    170 Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital Chelsea Michigan United States 48118
    171 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    172 McLaren Cancer Institute-Clarkston Clarkston Michigan United States 48346
    173 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    174 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    175 Henry Ford Hospital Detroit Michigan United States 48202
    176 Ascension Saint John Hospital Detroit Michigan United States 48236
    177 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    178 Weisberg Cancer Treatment Center Farmington Hills Michigan United States 48334
    179 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    180 Genesee Hematology Oncology PC Flint Michigan United States 48503
    181 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    182 Hurley Medical Center Flint Michigan United States 48503
    183 McLaren Cancer Institute-Flint Flint Michigan United States 48532
    184 Singh and Arora Hematology Oncology PC Flint Michigan United States 48532
    185 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    186 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    187 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    188 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    189 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    190 Ascension Borgess Cancer Center Kalamazoo Michigan United States 49009
    191 Karmanos Cancer Institute at McLaren Greater Lansing Lansing Michigan United States 48910
    192 Sparrow Hospital Lansing Michigan United States 48912
    193 Hope Cancer Clinic Livonia Michigan United States 48154
    194 Trinity Health Saint Mary Mercy Livonia Hospital Livonia Michigan United States 48154
    195 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    196 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    197 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    198 Toledo Clinic Cancer Centers-Monroe Monroe Michigan United States 48162
    199 McLaren Cancer Institute-Macomb Mount Clemens Michigan United States 48043
    200 McLaren Cancer Institute-Central Michigan Mount Pleasant Michigan United States 48858
    201 McLaren Cancer Institute-Northern Michigan Petoskey Michigan United States 49770
    202 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    203 Hope Cancer Center Pontiac Michigan United States 48341
    204 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    205 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    206 Huron Medical Center PC Port Huron Michigan United States 48060
    207 Lake Huron Medical Center Port Huron Michigan United States 48060
    208 McLaren-Port Huron Port Huron Michigan United States 48060
    209 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    210 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    211 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    212 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    213 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    214 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    215 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    216 Macomb Hematology Oncology PC Warren Michigan United States 48093
    217 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    218 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    219 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    220 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    221 Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus Ypsilanti Michigan United States 48197
    222 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    223 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    224 Minnesota Oncology - Burnsville Burnsville Minnesota United States 55337
    225 Mercy Hospital Coon Rapids Minnesota United States 55433
    226 Essentia Health - Deer River Clinic Deer River Minnesota United States 56636
    227 Essentia Health Cancer Center Duluth Minnesota United States 55805
    228 Fairview Southdale Hospital Edina Minnesota United States 55435
    229 Unity Hospital Fridley Minnesota United States 55432
    230 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    231 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    232 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    233 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    234 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    235 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    236 Health Partners Inc Minneapolis Minnesota United States 55454
    237 New Ulm Medical Center New Ulm Minnesota United States 56073
    238 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    239 Mayo Clinic in Rochester Rochester Minnesota United States 55905
    240 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    241 Regions Hospital Saint Paul Minnesota United States 55101
    242 United Hospital Saint Paul Minnesota United States 55102
    243 Essentia Health Sandstone Sandstone Minnesota United States 55072
    244 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    245 Lakeview Hospital Stillwater Minnesota United States 55082
    246 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    247 Ridgeview Medical Center Waconia Minnesota United States 55387
    248 Rice Memorial Hospital Willmar Minnesota United States 56201
    249 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    250 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    251 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    252 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    253 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    254 Parkland Health Center - Farmington Farmington Missouri United States 63640
    255 Washington University School of Medicine Saint Louis Missouri United States 63110
    256 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    257 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    258 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    259 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    260 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    261 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    262 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    263 Community Hospital of Anaconda Anaconda Montana United States 59711
    264 Billings Clinic Cancer Center Billings Montana United States 59101
    265 Saint Vincent Frontier Cancer Center Billings Montana United States 59102
    266 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    267 Saint James Community Hospital and Cancer Treatment Center Butte Montana United States 59701
    268 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    269 Great Falls Clinic Great Falls Montana United States 59405
    270 Saint Peter's Community Hospital Helena Montana United States 59601
    271 Kalispell Regional Medical Center Kalispell Montana United States 59901
    272 Community Medical Hospital Missoula Montana United States 59804
    273 CHI Health Saint Francis Grand Island Nebraska United States 68803
    274 Nebraska Cancer Specialists/Oncology Hematology West PC - MECC Omaha Nebraska United States 68114
    275 Nebraska Methodist Hospital Omaha Nebraska United States 68114
    276 Carson Tahoe Regional Medical Center Carson City Nevada United States 89703
    277 Cancer and Blood Specialists-Henderson Henderson Nevada United States 89052
    278 Comprehensive Cancer Centers of Nevada - Henderson Henderson Nevada United States 89052
    279 Comprehensive Cancer Centers of Nevada-Horizon Ridge Henderson Nevada United States 89052
    280 Las Vegas Cancer Center-Henderson Henderson Nevada United States 89052
    281 OptumCare Cancer Care at Seven Hills Henderson Nevada United States 89052
    282 Comprehensive Cancer Centers of Nevada-Southeast Henderson Henderson Nevada United States 89074
    283 GenesisCare USA - Henderson Henderson Nevada United States 89074
    284 Desert West Surgery Las Vegas Nevada United States 89102
    285 OptumCare Cancer Care at Charleston Las Vegas Nevada United States 89102
    286 University Medical Center of Southern Nevada Las Vegas Nevada United States 89102
    287 Hope Cancer Care of Nevada Las Vegas Nevada United States 89103
    288 Cancer and Blood Specialists-Shadow Las Vegas Nevada United States 89106
    289 Radiation Oncology Centers of Nevada Central Las Vegas Nevada United States 89106
    290 GenesisCare USA - Las Vegas Las Vegas Nevada United States 89109
    291 HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway Las Vegas Nevada United States 89109
    292 HealthCare Partners Medical Group Oncology/Hematology-San Martin Las Vegas Nevada United States 89113
    293 Radiation Oncology Centers of Nevada Southeast Las Vegas Nevada United States 89119
    294 Cancer Therapy and Integrative Medicine Las Vegas Nevada United States 89121
    295 Ann M Wierman MD LTD Las Vegas Nevada United States 89128
    296 Cancer and Blood Specialists-Tenaya Las Vegas Nevada United States 89128
    297 Comprehensive Cancer Centers of Nevada - Northwest Las Vegas Nevada United States 89128
    298 GenesisCare USA - Vegas Tenaya Las Vegas Nevada United States 89128
    299 HealthCare Partners Medical Group Oncology/Hematology-Tenaya Las Vegas Nevada United States 89128
    300 OptumCare Cancer Care at MountainView Las Vegas Nevada United States 89128
    301 Comprehensive Cancer Centers of Nevada-Summerlin Las Vegas Nevada United States 89144
    302 Summerlin Hospital Medical Center Las Vegas Nevada United States 89144
    303 Las Vegas Cancer Center-Medical Center Las Vegas Nevada United States 89148-2405
    304 Comprehensive Cancer Centers of Nevada Las Vegas Nevada United States 89148
    305 GenesisCare USA - Fort Apache Las Vegas Nevada United States 89148
    306 OptumCare Cancer Care at Fort Apache Las Vegas Nevada United States 89148
    307 HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills Las Vegas Nevada United States 89149
    308 Comprehensive Cancer Centers of Nevada - Central Valley Las Vegas Nevada United States 89169
    309 University Cancer Center Las Vegas Nevada United States 89169
    310 Hope Cancer Care of Nevada-Pahrump Pahrump Nevada United States 89048
    311 Renown Regional Medical Center Reno Nevada United States 89502
    312 Saint Mary's Regional Medical Center Reno Nevada United States 89503
    313 Radiation Oncology Associates Reno Nevada United States 89509
    314 Dartmouth Hitchcock Medical Center Lebanon New Hampshire United States 03756
    315 Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey United States 07920
    316 Englewood Hospital and Medical Center Englewood New Jersey United States 07631
    317 Memorial Sloan Kettering Monmouth Middletown New Jersey United States 07748
    318 Memorial Sloan Kettering Bergen Montvale New Jersey United States 07645
    319 The Valley Hospital-Luckow Pavilion Paramus New Jersey United States 07652
    320 Valley Hospital Ridgewood New Jersey United States 07450
    321 Valley Medical Group - Wayne Multispecialty Practice Wayne New Jersey United States 07470
    322 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    323 New Mexico Oncology Hematology Consultants Albuquerque New Mexico United States 87109
    324 Presbyterian Kaseman Hospital Albuquerque New Mexico United States 87110
    325 Presbyterian Rust Medical Center/Jorgensen Cancer Center Rio Rancho New Mexico United States 87124
    326 Hematology Oncology Associates of Central New York-Auburn Auburn New York United States 13021
    327 Roswell Park Cancer Institute Buffalo New York United States 14263
    328 Memorial Sloan Kettering Commack Commack New York United States 11725
    329 Hematology Oncology Associates of Central New York-East Syracuse East Syracuse New York United States 13057
    330 Memorial Sloan Kettering Westchester Harrison New York United States 10604
    331 Mount Sinai Hospital New York New York United States 10029
    332 Memorial Sloan Kettering Cancer Center New York New York United States 10065
    333 University of Rochester Rochester New York United States 14642
    334 Hematology Oncology Associates of Central New York-Onondaga Hill Syracuse New York United States 13215
    335 Memorial Sloan Kettering Nassau Uniondale New York United States 11553
    336 UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina United States 27599
    337 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    338 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    339 Margaret R Pardee Memorial Hospital Hendersonville North Carolina United States 28791
    340 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    341 Vidant Oncology-Kinston Kinston North Carolina United States 28501
    342 Marion L Shepard Cancer Center at Vidant Beaufort Hospital Washington North Carolina United States 27889
    343 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    344 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    345 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    346 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
    347 Strecker Cancer Center-Belpre Belpre Ohio United States 45714
    348 Adena Regional Medical Center Chillicothe Ohio United States 45601
    349 Case Western Reserve University Cleveland Ohio United States 44106
    350 Ohio State University Comprehensive Cancer Center Columbus Ohio United States 43210
    351 Columbus Oncology and Hematology Associates Inc Columbus Ohio United States 43214
    352 Grant Medical Center Columbus Ohio United States 43215
    353 The Mark H Zangmeister Center Columbus Ohio United States 43219
    354 Doctors Hospital Columbus Ohio United States 43228
    355 Delaware Health Center-Grady Cancer Center Delaware Ohio United States 43015
    356 OhioHealth Mansfield Hospital Mansfield Ohio United States 44903
    357 Marietta Memorial Hospital Marietta Ohio United States 45750
    358 OhioHealth Marion General Hospital Marion Ohio United States 43302
    359 Toledo Clinic Cancer Centers-Maumee Maumee Ohio United States 43537
    360 Toledo Radiation Oncology at Northwest Ohio Onocolgy Center Maumee Ohio United States 43537
    361 UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio United States 44060
    362 UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights Ohio United States 44130
    363 Licking Memorial Hospital Newark Ohio United States 43055
    364 University Hospitals Parma Medical Center Parma Ohio United States 44129
    365 Mercy Health Perrysburg Cancer Center Perrysburg Ohio United States 43551
    366 Southern Ohio Medical Center Portsmouth Ohio United States 45662
    367 Mercy Health - Saint Anne Hospital Toledo Ohio United States 43623
    368 Toledo Clinic Cancer Centers-Toledo Toledo Ohio United States 43623
    369 University Hospitals Sharon Health Center Wadsworth Ohio United States 44281
    370 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    371 Genesis Healthcare System Cancer Care Center Zanesville Ohio United States 43701
    372 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    373 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    374 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    375 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    376 Legacy Mount Hood Medical Center Gresham Oregon United States 97030
    377 Providence Newberg Medical Center Newberg Oregon United States 97132
    378 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    379 Legacy Good Samaritan Hospital and Medical Center Portland Oregon United States 97210
    380 Providence Portland Medical Center Portland Oregon United States 97213
    381 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    382 Legacy Meridian Park Hospital Tualatin Oregon United States 97062
    383 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    384 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    385 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    386 Saint Vincent Hospital Erie Pennsylvania United States 16544
    387 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    388 Jefferson Hospital Jefferson Hills Pennsylvania United States 15025
    389 Forbes Hospital Monroeville Pennsylvania United States 15146
    390 Thomas Jefferson University Hospital Philadelphia Pennsylvania United States 19107
    391 Fox Chase Cancer Center Philadelphia Pennsylvania United States 19111
    392 Temple University Hospital Philadelphia Pennsylvania United States 19140
    393 Allegheny General Hospital Pittsburgh Pennsylvania United States 15212
    394 West Penn Hospital Pittsburgh Pennsylvania United States 15224
    395 Wexford Health and Wellness Pavilion Wexford Pennsylvania United States 15090
    396 Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina United States 29316
    397 Prisma Health Cancer Institute - Easley Easley South Carolina United States 29640
    398 Prisma Health Cancer Institute - Butternut Greenville South Carolina United States 29605
    399 Prisma Health Cancer Institute - Faris Greenville South Carolina United States 29605
    400 Prisma Health Cancer Institute - Eastside Greenville South Carolina United States 29615
    401 Prisma Health Cancer Institute - Greer Greer South Carolina United States 29650
    402 Prisma Health Cancer Institute - Seneca Seneca South Carolina United States 29672
    403 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    404 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    405 Farmington Health Center Farmington Utah United States 84025
    406 University of Utah Sugarhouse Health Center Salt Lake City Utah United States 84106
    407 Huntsman Cancer Institute/University of Utah Salt Lake City Utah United States 84112
    408 Virginia Mason Medical Center Seattle Washington United States 98101
    409 Legacy Salmon Creek Hospital Vancouver Washington United States 98686
    410 Edwards Comprehensive Cancer Center Huntington West Virginia United States 25701
    411 West Virginia University Healthcare Morgantown West Virginia United States 26506
    412 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    413 Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin United States 54701
    414 University of Wisconsin Carbone Cancer Center Madison Wisconsin United States 53792
    415 Marshfield Medical Center-Marshfield Marshfield Wisconsin United States 54449
    416 Marshfield Clinic-Minocqua Center Minocqua Wisconsin United States 54548
    417 ProHealth D N Greenwald Center Mukwonago Wisconsin United States 53149
    418 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    419 ProHealth Oconomowoc Memorial Hospital Oconomowoc Wisconsin United States 53066
    420 Marshfield Medical Center-Rice Lake Rice Lake Wisconsin United States 54868
    421 Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin United States 54482
    422 ProHealth Waukesha Memorial Hospital Waukesha Wisconsin United States 53188
    423 UW Cancer Center at ProHealth Care Waukesha Wisconsin United States 53188
    424 Marshfield Medical Center - Weston Weston Wisconsin United States 54476
    425 Billings Clinic-Cody Cody Wyoming United States 82414
    426 Welch Cancer Center Sheridan Wyoming United States 82801

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Jennifer A Chan, Alliance for Clinical Trials in Oncology

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT03375320
    Other Study ID Numbers:
    • NCI-2017-02297
    • NCI-2017-02297
    • A021602
    • A021602
    • U10CA180821
    First Posted:
    Dec 18, 2017
    Last Update Posted:
    Aug 15, 2022
    Last Verified:
    Jun 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Aug 15, 2022