Bladder-PAD: Augmented Bladder Tumor Detection Using Real Time Based Artificial Intelligence
Study Details
Study Description
Brief Summary
Today the standard for the diagnosis and monitoring of bladder tumors is bladder endoscopy. The performance of this exam is not perfect. With this work, based on artificial intelligence, the investigators wish to combine endoscopy with a complementary diagnostic tool in order to improve patient care. The main objective will be to reduce diagnostic errors / wanderings in patients treated or followed for bladder tumors, by imposing a new standard of diagnostic bladder mapping (high PPV and VPN, high precision)(primary purpose diagnostic). The secondary objective will be to homogenize and systematize the descriptive part of the lesions, and to use AI to better characterize tumor aggressiveness. The final objective being to validate a new precision tool (diagnostic companion) essential for developing and standardizing the therapeutic management of bladder tumors (correcting inter-observer heterogeneity).
In this project, video frame will be first extracted from our dataset of cystoscopy videos hosted in in the Next Cloud Recherche. Selected medical image will be segmented and analyzed using our pre-trained CNN model with a feature detection algorithm to obtain features.
Data will be analyzed on both patient and lesion levels. The study will assess the Bladder-PAD accuracy on the detection of bladder tumors, and its ability to predict tumor risk of recurrence and progression.
Condition or Disease | Intervention/Treatment | Phase |
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Study Design
Outcome Measures
Primary Outcome Measures
- Tumor detection rate of white light cystoscopy [one day]
- Tumor detection rate of Bladder-PAD cystoscopy [one day]
- Tumor false detection rate of white light cystoscopy [one day]
- Tumor false detection rate of Bladder-PAD cystoscopy [one day]
Eligibility Criteria
Criteria
Inclusion Criteria:
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unifocal primary or recurrent suspected bladder cancer with tumor size less or equal than 3 cm
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multifocal primary or recurrent suspected bladder cancer less or equal than 5 lesions and with tumor size less or equal than 3 cm.
Exclusion Criteria:
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Evidence of more than 5 tumors or more than 3 cm
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computed tomography/cystoscopy suspect of muscle-invasive bladder cancer (cT2 or higher)
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computed tomography/magnetic resonance evidence of distant metastases (lymphatic or organic)
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Exclusion criteria will include gross hematuria and bacillus Calmette-Guerin (BCG) treatment or chemotherapy within 3 months of inclusion
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An exception will be made if patients had received only a single course of chemotherapy immediately following TUR
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Patients objecting to the use of their data in the context of research.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Amiens University Hospital | Amiens | France | 80054 |
Sponsors and Collaborators
- Centre Hospitalier Universitaire, Amiens
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PI2022_843_0014