QUANTICO-RETRO: Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure

Sponsor

University Hospital, Strasbourg, France (Other)

Overall Status

Recruiting

CT.gov ID

NCT04534400

Collaborator

VISIBLE PATIENT, E-MEDIA (Other)

1,000

Enrollment

Locations

Anticipated Duration (Months)

500

Patients Per Site

11.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.

This study aim at assessing the correlation between the amount of radiologic pulmonary alteration and the clinical severity in two clinical situation :

SARS-CoV-2 infections
Postoperative hypoxemic acute respiratory failure

Condition or Disease	Intervention/Treatment	Phase
SARS-CoV-2 Infection Respiratory Failure With Hypoxia	Radiation: thoracic CT-scan

Study Design

Study Type:

Observational

Anticipated Enrollment :

1000 participants

Observational Model:

Cohort

Time Perspective:

Retrospective

Official Title:

Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic

Actual Study Start Date :

Sep 1, 2020

Anticipated Primary Completion Date :

Mar 1, 2024

Anticipated Study Completion Date :

Mar 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
Patients with SARS-CoV-2 infection	Radiation: thoracic CT-scan Automated measurement
Patients with Postoperative hypoxemic respiratory failure	Radiation: thoracic CT-scan Automated measurement

Arm

Intervention/Treatment

Patients with SARS-CoV-2 infection

Radiation: thoracic CT-scan

Automated measurement

Patients with Postoperative hypoxemic respiratory failure

Radiation: thoracic CT-scan

Automated measurement

Outcome Measures

Primary Outcome Measures

Correlation between altered pulmonary volume and ordinal severity scale [2 days after CT scan]

Secondary Outcome Measures

Correlation between altered pulmonary volume and ordinal severity scale [7 days after CT scan]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Inclusion Criteria:

patient with insurance covering
patient admitted to the participating hospitals for SARS-CoV-2 infection or postoperative acute hypoxemic respiratory failure between 01/01/2019 and 05/11/2020

Exclusion Criteria:

patient transferred to another hospital than the participating center during the 7 days following the CT scan

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	HÔPITAUX UNIVERSITAIRES DE STRASBOURG, Hôpital de Hautepierre, Service de Réanimation Médicale	Strasbourg		France	67098
2	Hôpitaux Universitaires de Nancy Service d'anesthésie réanimation Hôpital de Brabois	Vandœuvre-lès-Nancy		France	54500

Sponsors and Collaborators

University Hospital, Strasbourg, France
VISIBLE PATIENT, E-MEDIA

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

University Hospital, Strasbourg, France

ClinicalTrials.gov Identifier:

NCT04534400

Other Study ID Numbers:

7888

First Posted:

Sep 1, 2020

Last Update Posted:

Dec 16, 2021

Last Verified:

Dec 1, 2021

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

COVID-19

Respiratory Insufficiency

Hypoxia

Study Results

No Results Posted as of Dec 16, 2021