Genetic Risks for Bicuspid Aortic Valve Disease
Study Details
Study Description
Brief Summary
Bicuspid Aortic Valve (BAV) is the most common congenital heart malformation in adults, but very little is known about the genetic causes or risk factors for adverse outcomes. Currently, it is estimated that most cases of aortic stenosis in patients less than 65 years old are caused by BAVs. BAV patients are also at high risk to develop aneurysms of the ascending aorta, which may lead to aortic dissections. Dr. Prakash and his colleagues plan to use individual genetic information to identify persons with BAV who are at high risk for complications and to customize therapies.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
To be included in the study, patients must have a bicuspid or unicuspid aortic valve, documented by clinical history or imaging studies. If the aortic valve was replaced surgically, they may still be eligible. Participants will be asked to donate a single tube of blood and fill out a questionnaire. Patients will also be followed up by telephone or email about once a year to determine if they experience any medical complications related to Bicuspid Aortic Valve (BAV), such as aortic aneurysms, aortic dissections or valve disease. Patients may not be included if they are less than 18 years old at the time of recruitment or have a recognized genetic syndrome or genetic mutation such as Marfan or Ehlers-Danlos syndrome.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| BAV Cohort Patients with bicuspid or unicuspid aortic valves, regardless of surgical status. |
Outcome Measures
Primary Outcome Measures
- Thoracic aortic aneurysms and dissections [10 years]
Development of new aneurysms and/or dissections of the thoracic aorta
- Aortic valve replacement surgery [10 years]
Secondary Outcome Measures
- Aortic enlargement [10 years]
Dilation of thoracic aorta, new or progressive
Other Outcome Measures
- Aortic valve degeneration [10 years]
Increase in valve degeneration score by at least 1 unit
Eligibility Criteria
Criteria
Inclusion Criteria:
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At least 18 years of age
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Diagnosis of bicuspid or unicuspid aortic valve
Exclusion Criteria:
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Less than 18 years of age
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Recognized syndrome or identified genetic mutation
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | University of Texas Health Science Center Houston | Houston | Texas | United States | 77030 |
Sponsors and Collaborators
- The University of Texas Health Science Center, Houston
Investigators
- Principal Investigator: Siddharth Prakash, MD, PhD, The University of Texas Health Science Center, Houston
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- HSC-MS-11-0185