Binocular Vision Alternations and fMRI Activation After ICL Implantation for High Myopia
Study Details
Study Description
Brief Summary
Implantable collamer lens (ICL) is one of the most effective operation for high myopia. Due to refractive correction changed, and prism effect of the spectacle removed, in the early stage after ICL implantation, binocular function might be dysfunction, leading to asthenopia, blurred vision, double vision and so on. This study will recruit the high myopia subjects that scheduled for ICL implantation, purpose to investigate the binocular vision alternations and brain activation that impacted by ICL implantation.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Study Design
Outcome Measures
Primary Outcome Measures
- Changes of phoria at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Phoria was measured by phoropter.
- Changes of AC/A at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Gradient AC/A was measured by phoropter.
- Changes of fusion vergence at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Fusion vergence was measured by phoropter.
- Changes of accommodative response at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Accommodative response was measured using monocular estimated method.
- Changes of relative accommodation at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Relative accommodation was measured by phoropter.
- Changes of near point of convergence at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Near point of convergence was measured using push-up method.
- Changes of accommodation amplitude at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Accommodative amplitude was measured using push-up method.
- Changes of vergence facility at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Vergence facility was measured by +2.00D/-2.00D flipper.
- Changes of accommodative facility at different time points [The examination was performed before operation and 1 week, 1 month, 3 monthes, 6 monthes after ICL implantation.]
Accommodative facility was measured by 3△BI/12△BO flipper.
Secondary Outcome Measures
- Changes of brain activation at different time points [The examination was performed before operation and 1 month, 6 monthes after ICL implantation.]
Functional magnetic resonance imaging activation of the brain
Eligibility Criteria
Criteria
Inclusion Criteria:
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Age 18-35
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Spherical equivalent over -6.00DS, astigmatism within -2.00DC, anisometropia within -2.00DS
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BCVA ≥ 0.8
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Plan to accept implantable collamer lens surgery
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Near point of convergence within 10cm
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Positive fusion vergence over 20pd
Exclusion Criteria:
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Stabismus
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Previous ocular surgery or trauma
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History of vision therapy
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Monovision and nystagmus
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Mental disease or craniocerebral trauma
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Zhongshan Ophthalmic Center, Sun Yat-sen University | Guangzhou | Guangdong | China | 510060 |
Sponsors and Collaborators
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Additional Information:
- Accommodative changes after SMILE for moderate to high myopia correction.
- Changes in fusional vergence amplitudes after laser refractive surgery for moderate myopia.
- Prism adaptation changes resting-state functional connectivity in the dorsal stream of visual attention networks in healthy adults: A fMRI study.
- Prism adaptation enhances decoupling between the default mode network and the attentional networks.
Publications
- Han J, Hong S, Lee S, Kim JK, Lee HK, Han SH. Changes in fusional vergence amplitudes after laser refractive surgery for moderate myopia. J Cataract Refract Surg. 2014 Oct;40(10):1670-5. doi: 10.1016/j.jcrs.2014.01.043. Epub 2014 Aug 20.
- Tsujimoto K, Mizuno K, Nishida D, Tahara M, Yamada E, Shindo S, Kasuga S, Liu M. Prism adaptation changes resting-state functional connectivity in the dorsal stream of visual attention networks in healthy adults: A fMRI study. Cortex. 2019 Oct;119:594-605. doi: 10.1016/j.cortex.2018.10.018. Epub 2018 Oct 31.
- Wilf M, Serino A, Clarke S, Crottaz-Herbette S. Prism adaptation enhances decoupling between the default mode network and the attentional networks. Neuroimage. 2019 Oct 15;200:210-220. doi: 10.1016/j.neuroimage.2019.06.050. Epub 2019 Jun 22.
- Zheng K, Han T, Zhou X. Accommodative changes after SMILE for moderate to high myopia correction. BMC Ophthalmol. 2016 Oct 4;16(1):173. doi: 10.1186/s12886-016-0352-8.
- 2022KYPJ198