Biology Studies of Hematologic Cancers

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Enrolling by invitation
CT.gov ID
NCT00923442
Collaborator
(none)
550
1

Study Details

Study Description

Brief Summary

This study will collect tumor samples from people with cancers of the blood, bone marrow, or lymph glands for laboratory study of the biology of these conditions. Such studies contribute to a better understanding of cancer biology and to the development of new treatments. Planned studies include:

  • Examination of individual cancer cells and to search for differences compared to other types of cancer and normal cells

  • Examination of the chromosomes and genes in cancer cells and to search for differences compared to other types of cancer and normal cells

  • Development of sensitive methods to detect small amounts of cancer that remain after treatment

  • Search for new cancer proteins that might serve as targets for treatment

  • Investigation of methods to develop cancer vaccines.

Patients from >= 1 to 75 years of age with acute lymphocytic leukemia, acute myelogenous leukemia, myelodysplastic syndrome, chronic myelogenous leukemia, juvenile myelomonocytic leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, and other hematologic malignancies may be eligible for this study.

Blood or bone marrow samples will be collected when sampling is required for the patient's medical care. Cells from some individuals will be grown in test tubes, establishing cell lines or in animals, establishing xenograft models. (A xenograft is transplantation of cells of one species to another species.)

Detailed Description

Background:

Laboratory-based investigations have contributed to an improved understanding of pathophysiology and to the development of new therapies for hematologic malignancies.

The aim of this protocol is to facilitate biologic study of leukemias, pre-malignant conditions, myelodysplastic syndromes, lymphomas, and other blood disorders.

This is a sample acquisition protocol for targeted study of hematologic malignancies by a collaborative network of NIH investigators from multiple Institutes/Centers.

Objective:

This biology protocol is designed to allow sample acquisition for use in the study of hematologic malignancies. A variety of laboratory investigations designed to support NIH translational trials; to apply new methodologies in the study of cellular, and molecular biology; to probe for new therapeutic targets; and to develop new treatment approaches will be performed.

Eligibility:

Diagnosis of any hematologic malignancy or pre-malignant conditions, including but not restricted to the following: Acute Lymphocytic Leukemia (ALL), Acute Myelogenous Leukemia (AML), Myelodysplastic Syndrome (MDS), Chronic Myelogenous Leukemia (CML), Juvenile Myelomonocytic Leukemia (JMML, J-CML), Non-Hodgkin s Lymphoma (NHL), Hodgkin s Disease

Tumor tissue that has been previously collected and is available for study or that can be collected with minimal additional risk to the subject during sampling required for routine patient care.

Patient age: >= 1 to 75 years.

Design:

Biologic assays relevant to the investigation of hematologic malignancies will be performed in an exploratory fashion, some studies are developmental, i.e., assay design in support of current or planned CC clinical trials. Others are standard assays that will be applied in attempt to identify new targets or test new therapeutic approaches.

.

Study Design

Study Type:
Observational
Anticipated Enrollment :
550 participants
Observational Model:
Cohort
Time Perspective:
Prospective
Official Title:
Hematologic Malignancy Biology Study
Actual Study Start Date :
Feb 24, 2004

Arms and Interventions

Arm Intervention/Treatment
1

patients (from >/= 1 to 75 years old) diagnosed with any hematologic malignancy or pre-malignant condition

Outcome Measures

Primary Outcome Measures

  1. Tissue acquisition for lab investigations [1 Month]

    The examination of biologic assays relevant to the investigation of hematologic malignancies

Eligibility Criteria

Criteria

Ages Eligible for Study:
1 Year to 75 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
  • INCLUSION CRITERIA

Confirmed pathological diagnosis of any hematologic malignancy or pre-malignant blood disorder, including but not restricted to the following:

Acute Lymphocytic Leukemia (ALL)

Acute Myelogenous Leukemia (AML)

Myelodysplastic Syndrome (MDS)

Chronic Myelogenous Leukemia (CML)

Juvenile Myelomonocytic Leukemia (JMML, J-CML)

Non-Hodgkin's Lymphoma (NHL)

Hodgkin's Disease

Tumor tissue that has been previously collected and is available for study or that can be collected with minimal additional risk to the subject during sampling required for routine patient care.

Patient age: >= 1 to 75 years.

Prior therapy: no restrictions

Subject, parent/guardian, legally authorized representative (LAR), or durable power of attorney must be able to give informed consent and sign the informed consent document.

EXCLUSION CRITERIA

None

Contacts and Locations

Locations

Site City State Country Postal Code
1 National Institutes of Health Clinical Center Bethesda Maryland United States 20892

Sponsors and Collaborators

  • National Cancer Institute (NCI)

Investigators

  • Principal Investigator: Nirali N Shah, M.D., National Cancer Institute (NCI)

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publications

None provided.
Responsible Party:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00923442
Other Study ID Numbers:
  • 040102
  • 04-C-0102
  • NCT00900393
First Posted:
Jun 18, 2009
Last Update Posted:
Aug 3, 2022
Last Verified:
Jul 29, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by National Cancer Institute (NCI)
Additional relevant MeSH terms:

Study Results

No Results Posted as of Aug 3, 2022