Biomarkers in Tissue Samples From Patients With Stage I or Stage III Endometrial Cancer
Study Details
Study Description
Brief Summary
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying at biomarkers in tissue samples from patients with stage I or stage III endometrial cancer.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Detailed Description
OBJECTIVES:
- To identify microRNA expression patterns associated with lymph node metastasis in samples from patients with endometrial cancer.
OUTLINE: Banked tumor tissue specimens are analyzed for microRNA expression profiling by microarray analysis and reverse transcriptase-PCR assays.
Study Design
Outcome Measures
Primary Outcome Measures
- Association between microRNA expression and lymph node metastasis []
Eligibility Criteria
Criteria
DISEASE CHARACTERISTICS:
-
Histologically confirmed endometrioid endometrial cancer
-
Stage IA, IB, IC, or IIIC disease
-
Any grade
-
Enrolled and evaluated on GOG-0210 Molecular Staging Study of Endometrial Cancer
-
Consented to allow their specimens and clinical data to be collected and stored for future research
-
Underwent complete surgical staging, including the following:
-
Hysterectomy
-
Bilateral oophorectomy
-
Washings as well as pelvic lymphadenectomy (sampling of four left and four right pelvic lymph nodes)
-
Para-aortic lymphadenectomy (sampling of one left and one right para-aortic lymph node)
-
Sufficient high-quality frozen primary tumor for testing with ≥ 75% tumor cellularity and ≤ 10% necrosis
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Gynecologic Oncology Group
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: David S. Miller, MD, Simmons Cancer Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CDR0000672415
- GOG-8014