Combined Dexmedetomidine and Glycopyrrolate Therapy
Study Details
Study Description
Brief Summary
Catheter-related bladder discomfort after transurethral resection of bladder tumor is frequent because of indwelling urinary catheter for irrigation. The mechanism of the catheter-related bladder discomfort is similar to that of overactive bladder, in which muscarinic acetylcholine receptors are stimulated. The catheter-related bladder discomfort is a well known predisposing factor for emergence delirium after general anesthesia. In this study, we aimed to compare the incidence of catheter-related bladder discomfort between dexmedetomidine only therapy and combind dexmedetomidine and glycopyrrolate therapy.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Active Comparator: Dexmedetomidine only dexmedetomidine is administered during the surgery |
Drug: Dexmedetomidine
Dexmedetomidine administration during the surgery.
|
| Experimental: Combined dexmedetomidine and glycopyrrolate glycopyrrolate and dexmedetomidine are administered during the surgery |
Drug: Glycopyrrolate + dexmedetomidine
Intravenous glycopyrrolate before anesthetic induction. Dexmedetomidine administration during the surgery.
|
Outcome Measures
Primary Outcome Measures
- The incidence of catheter-related bladder discomfort [0 minute after entering the post-anesthetic care unit]
No = not complaining of bladder discomfort on asking; Mild = report discomfot only on questioning; Moderate: report without questioning without behavior responses; Severe = report without questioniing accompanied by behavior responses. Mild, Moderate, Severe bladder discomfort is defined to have catheter-related bladder discomfort
Secondary Outcome Measures
- Emergence agitation [0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit]
(1)calm (2)slightly agitated but consolable (3)moderately agitated and inconsolable (4)severely agitated and highly inconsolable
- Delirium [0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit]
(1)acute and fluctuating changes in mental status (2)inattention (3)disorganized or incoherent thinking (4)altered level of consciousness. (1),(2) and (3), (1),(2), and (4), or (1)(2)(3)and (4) are defined to have deilrium.
- Postoperative pain [0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit]
numerical rating scale (0=no pain to 10=worst pain imaginable)
- Sedation score [0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit]
(1)anxious, agitated or restless (2)cooperative, oriented and trranquil (3)responds to commands, asleep (4)brisk response to light glabellar taps or oud noise (5)sluggish response to light glabellar taps or loud noise (6)noresponse
- Dry mouth [0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit]
yes or no
- postoperative nausea and vomiting [0 minute, 30 minute, and 6 hours after entering the post-anesthetic care unit]
yes or no
Eligibility Criteria
Criteria
Inclusion Criteria:
-
American Society of Anesthesiologists physical status I and II
-
elective transurethral resection of bladder tumor under general anesthesia
Exclusion Criteria:
-
arrhythmia
-
bladder outflow obstruction
-
overacitve bladder
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end stage renal disease
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neurogenic bladder
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morbid obesity
-
psychiatric disorder
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Kangbuk Samsung Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- DEXLYCO