Evaluation of Blood Platelet Indices,Platelet Aggregation in the Activity of IBD Patients on Biological Treatment
Study Details
Study Description
Brief Summary
ulcerative colitis and Crohn's disease, the two major forms of inflammatory bowel disease, are chronic, idiopathic, relapsing inflammatory conditions of the gastrointestinal tract. The mechanism is multifactorial and may result from the combined interaction of environmental, genetic, epithelial barrier defects, dysregulated immune responses, and microbial factors
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Histopathological examinations play a role in the diagnosis and management of UC, but they are costly and invasive. So, non-invasive inflammatory biomarkers of IBD, such as the WBCS, ESR and CRP are used in clinical practice .
Platelets play a critical role in blood hemostasis so impaired platelet activation may cause persistent mucosal inflammation. Many studies have demonstrated that patients with IBD may have increased risks of venous thrombosis. Thrombosis is a major cause of morbidity and mortality in IBD.
Platelet to lymphocyte ratio can be easily calculated from CBC can serve as useful biomarkers for predicting mucosal inflammation in UC.
Current disease management guidelines were focused on the use of anti-inflammatory agents, aminosalicylates, and corticosteroids. However, some patients are still refractory to these therapies.
Biological therapy has revolutionized the management of inflammatory bowel disease in the last few years. There available biologic medicines are infliximab, adalimumab, golimumab, vedolizumab, and ustekinumab. Biological therapy brought a better control of inflammatory bowel diseases. Its use requires specific care before the beginning and during the treatment.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
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healthy group the healthy group, not diagnosed IBD |
Biological: Infliximab
obseravation with investigation
|
IBD patients controlled by conventional treatment controlled by conventional treatment and divided to UC group and Crohns group |
Biological: Infliximab
obseravation with investigation
|
uncontrolled IBD patients on biological's treatment divided to uc received biological and Crohns received biolgical |
Biological: Infliximab
obseravation with investigation
|
Outcome Measures
Primary Outcome Measures
- detect of disease activity of IBD patients received biological treatment in the start and in 14 weeks after treatment compared to whose controlled by platelet indices and platelet lymphocytic ratio. [about 14 weeks after start of treatment of inflixmab]
Evaluation of disease activity of IBD patients received biological treatment in the start and in 14 weeks after treatment compared to whose controlled by platelet indices and platelet lymphocytic ratio.
Eligibility Criteria
Criteria
Inclusion Criteria:
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All patients diagnosed with inflammatory bowel disease ulcerative colitis or crohn's disease
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All IBD patients received biological treatment
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All IBD patients controlled with conventional treatment
Exclusion Criteria:
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IBS patients
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IBD Patients with: a) another autoimmune disease like ITP and SLE B) Bleeding tendency as hemophilia or thrombophilia C) Previous thrombotic events or on anticoagulants or antiplatelet drugs D) With another comorbidity as liver cell failure, respiratory failure, renal failure and cardiac failure
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- AssuitU22