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The Brain Activation During Different Motor Patterns in Healthy Adults

Sponsor
National Taiwan University Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT04868929
Collaborator
(none)
35
Enrollment
1
Location
10
Anticipated Duration (Months)
3.5
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study aims to investigate the brain activation during different motor patterns, including motor execution (ME), motor imagery (MI), action observation (AO) and mirror visual feedback (MVF). In addition, the relations between brain activation and motor performance will also be explored. This study includes two parts, which are upper limb and lower limb part. While executing all the tasks, brain activation in primary motor cortex(M1), premotor cortex(PMC), and supplementary motor cortex(SMA) will be monitored by functional near-infrared spectroscopy. One-way ANOVA with repeated measure will be used to detect the differences of brain activation level between each mode. Pearson correlation coefficient will be used to determine the relations of brain activation and motor performance.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    In upper limb part, subjects will be instructed to execute functional reaching task in ME, MI, AO, and MVF mode. During ME mode, motor performance including maximum speed, maximum acceleration, and jerk will be collected simultaneously. In the lower limb part, subjects will be instructed to walking over ground in ME, MI, and AO mode. During ME mode, the temporal and spatial gait parameters, including speed, stride time, cadence, and stride length will be collected.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    35 participants
    Observational Model:
    Case-Crossover
    Time Perspective:
    Cross-Sectional
    Official Title:
    The Brain Activation During Motor Execution, Motor Imagery, Action Observation, and Mirror Visual Feedback in Healthy Adults
    Anticipated Study Start Date :
    May 1, 2021
    Anticipated Primary Completion Date :
    Feb 28, 2022
    Anticipated Study Completion Date :
    Feb 28, 2022

    Outcome Measures

    Primary Outcome Measures

    1. Brain activities over primary motor cortex [Day 1]

      A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

    2. Brain activities over premotor cortex [Day 1]

      A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

    3. Brain activities over supplementary motor area [Day 1]

      A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

    Secondary Outcome Measures

    1. Motor performance of upper limb -maximum speed [Day 1]

      cm/s

    2. Motor performance of upper limb -maximum acceleration [Day 1]

      cm/s^2

    3. Motor performance of upper limb - jerk [Day 1]

      cm/s^3

    4. Motor performance of lower limb - gait speed [Day 1]

      cm/s

    5. Motor performance of lower limb - cadence [Day 1]

      steps

    6. Motor performance of lower limb - stride time [Day 1]

      second

    7. Motor performance of lower limb - stride length [Day 1]

      cm

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 30 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    • Inclusion Criteria

    1. Age between 20 to 30 years.

    2. Right-handed.

    3. Ability to walk 30 meters independently without an assistive device.

    4. No neurogical, cardiopulmonary, or muscle diseases that might interfere with the experiment.

    5. Mini-Mental State Examination (MMSE) score greater than 24.

    • Exclusion Criteria 1. Physiological condition is unstable.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 National Taiwan University Hospital Taipei Taiwan

    Sponsors and Collaborators

    • National Taiwan University Hospital

    Investigators

    • Principal Investigator: Yanci Liu, PHD, National Taiwan University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    National Taiwan University Hospital
    ClinicalTrials.gov Identifier:
    NCT04868929
    Other Study ID Numbers:
    • 202102037RINA
    First Posted:
    May 3, 2021
    Last Update Posted:
    May 6, 2021
    Last Verified:
    Apr 1, 2021
    Keywords provided by National Taiwan University Hospital
    brain activation
    near infrared spectroscopy
    motor imagery
    action observation
    mirror visual feedback

    Study Results

    No Results Posted as of May 6, 2021