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Brain Activity in Adults With ADHD During Neuropsychological Tasks

Sponsor
Kantonsspital Aarau (Other)
Overall Status
Completed
CT.gov ID
NCT02578342
Collaborator
(none)
45
Enrollment
1
Location
63
Duration (Months)
0.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.

Condition or Disease Intervention/Treatment Phase
  • Device: MRI

Detailed Description

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood.

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.

Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.

Study Design

Study Type:
Observational
Actual Enrollment :
45 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching
Study Start Date :
Aug 1, 2015
Actual Primary Completion Date :
May 1, 2020
Actual Study Completion Date :
Nov 1, 2020

Arms and Interventions

Arm Intervention/Treatment
Healthy volunteers

healthy volunteer between age of 20 to 55 will undergo MRI examination.

Device: MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
ADHD subjects without medication

Medication-naive subjects with ADHD (20-55 years) will undergo MRI examination.

Device: MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
ADHD subjects with medication

Subjects with ADHD (20-55 years), under medication will undergo MRI examination.

Device: MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency

Outcome Measures

Primary Outcome Measures

  1. Changes in blood oxygenation level dependency (BOLD) [2 hours]

    The study consist solely of one MRI examination performed within 2 hours.

Eligibility Criteria

Criteria

Ages Eligible for Study:
20 Years to 55 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • Participant is between 20-55 years old

  • Participant is not pregnant

Exclusion Criteria:

  • Participant is not able to consent him/herself

  • Suspected or proven pregnancy

  • Nursing

  • Neurological diseases that could interfere with a diagnosis of ADHD

  • Psychiatric comorbidity under treatment

  • Previous history of psychiatric medication

  • Substance abuse

  • Intelligence quotient<75

  • Claustrophobia

  • Electrical simulator nerve or bone

  • Implanted medication infusion pump

  • Cerebral aneurysm clips

  • Unstable medical condition

Contacts and Locations

Locations

Site City State Country Postal Code
1 Kantonsspital Aarau Aarau Aargau Switzerland 5001

Sponsors and Collaborators

  • Kantonsspital Aarau

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Luca Remonda, Prof. Dr. med., Kantonsspital Aarau
ClinicalTrials.gov Identifier:
NCT02578342
Other Study ID Numbers:
  • 1410.000.055
First Posted:
Oct 16, 2015
Last Update Posted:
Apr 7, 2022
Last Verified:
Apr 1, 2022
Additional relevant MeSH terms:
Hyperkinesis
Attention Deficit Disorder with Hyperactivity

Study Results

No Results Posted as of Apr 7, 2022