The Efficacy and Safety of PEG-rhG-CSF in Preventing Chemotherapy-induced Neutropenia

Sponsor
wang shusen (Other)
Overall Status
Unknown status
CT.gov ID
NCT02761460
Collaborator
(none)
338
1
1
30.9
10.9

Study Details

Study Description

Brief Summary

The purpose of this study is to evaluate the safety and efficacy of PEG-rhG-CSF in preventing chemotherapy-induced neutropenia

Condition or Disease Intervention/Treatment Phase
Phase 3

Detailed Description

Neutrophilic granulocytopenias is one of the most common and most serious complications in chemotherapy. Research shows that about 25% ~ 40% in patients receiving standard chemotherapy can appear neutropenia with fever. It can increase the risk of infection and Chemotherapy related death, and lead to the delay of chemotherapy, and maybe Reduce the curative effect of chemotherapy. RhG-CSF has widely used to prevent neutropenia, but its half-time is short, and need daily injections to maintain the effective blood drug concentration. Patients are with poor compliance, related adverse reaction and medical costs increase. At the same time, some patients appear neutropenia thought RhG-CSF is given. Therefore, how to reduce the frequency of RhG-CSF injections and more effectively prevent neutropenia more effectively, on the premise of ensure the safety of patients to achieve better effect of chemotherapy, has always been the focus of the clinical problem.

Pegylated recombinant human granulocyte-colony stimulating factor(PEG-rhG-CSF) is a first class national new drug developed by domestic pharmaceutical companies. According to some phase Ⅱand phase Ⅲ clinical trials, PEG-rhG-CSF has a good effect. The patients need only one injection for PEG-rhG-CSF each Cycle of chemotherapy, and the effect of rising white blood cell is more smoothly, and it can avoid pain of repeated injection of PEG-rhG-CSF

Study Design

Study Type:
Interventional
Anticipated Enrollment :
338 participants
Allocation:
N/A
Intervention Model:
Single Group Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
The Study of Evaluating the Efficacy and Safety of PEG-rhG-CSF in Preventing Chemotherapy-induced Neutropenia
Actual Study Start Date :
May 4, 2016
Anticipated Primary Completion Date :
Apr 1, 2018
Anticipated Study Completion Date :
Dec 1, 2018

Arms and Interventions

Arm Intervention/Treatment
Experimental: PEG-rhG-CSF

PEG-rhG-CSF 6mg is given for patients Greater than or equal to 45 kg, 3mg is given for those less than 45kg 24-48 hours after chemotherapy,

Drug: PEG-rhG-CSF
PEG-rhG-CSF 6mg is given for patients Greater than or equal to 45 kg, 3mg is given for those less than 45kg 24-48 hours after chemotherapy

Outcome Measures

Primary Outcome Measures

  1. the rate of Ⅲ or Ⅳ class of neutropenia [1 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 70 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  1. Provision of informed consent Histologically proven breast cancer

  2. Patients need to accept many cycles chemotherapy alone

  3. appears III/IV neutropenia after last cycle of chemotherapy, and plan in the subsequent cycle using the same chemotherapy program.

  4. KPS≥70

  5. Lifetime is expected to more than 3 months

  6. Before enrollment,ANC≥ANC ≥1.5×109 /L,Platelet Count (PLT) ≥80×109 /L, White Blood Cell (WBC )≥3.0×109 /L.

  7. Sign Informed Consent Form (ICF).

Exclusion Criteria:
  1. There is any difficult to control infection, or within 72 h before chemotherapy received antibiotic treatment systematically

  2. Any abnormal bone marrow hyperplasia and other hematopoietic function was abnormal

  3. Suffer from other malignant tumor was not cured, or patients with brain metastasis

  4. Total Bilirubin (TBIL),Alanine Transminase (ALT),Aspartate aminotransferase(AST)>2.5×ULN

  5. Cr>1.5×ULN

  6. Be allergic to this product or other genetically engineered e. coli sources of biological products

  7. Mental or neurological disorders

  8. Women with pregnancy or lactation; The childbearing age women refused to accept contraception

  9. The investigators think that the person doesn't fit into the group

Contacts and Locations

Locations

Site City State Country Postal Code
1 Shusen Wang Guangzhou Guangdong China 510060

Sponsors and Collaborators

  • wang shusen

Investigators

  • Study Chair: Shusen Wang, Doctor, Sun Yat-sen University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
wang shusen, Chief Physician, Sun Yat-sen University
ClinicalTrials.gov Identifier:
NCT02761460
Other Study ID Numbers:
  • 2015-FXY-083
First Posted:
May 4, 2016
Last Update Posted:
Jun 1, 2017
Last Verified:
May 1, 2017
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Additional relevant MeSH terms:

Study Results

No Results Posted as of Jun 1, 2017