Analysis of Breast-Conserving Surgery Plus Whole-Breast Irradiation Versus Mastectomy
Study Details
Study Description
Brief Summary
This is a retrospective propensity score-matched analysis of a large institutional cohort of patients in order to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery or mastectomy for breast cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
The aim of the study is to compare long-term outcomes and clinicopathologic characteristics between patients treated with breast conserving surgery + whole breast irradiation or mastectomy for breast cancer.
Recent observations regarding long-term outcomes among patients with early-stage breast cancer who underwent breast-conserving surgery plus whole-breast irradiation or mastectomy are from a small number of registry-based studies.
Therefore, these findings may overestimate differences in survival between the two groups, compared with randomized controlled trials conducted in the 1980s.
This study performed a propensity score-matched analysis in a cohort of 9710 patients aged <70 years who underwent breast conserving surgery + whole breast irradiation or mastectomy without external radiotherapy for a first primary breast cancer (pT1-2, N0-3a) at the European Institute of Oncology between 2000 and 2008.
Patients were matched by propensity score.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Breast-conserving surgery Patients who underwent breast-conserving surgery plus whole-breast irradiation |
Procedure: Breast-conserving surgery
Breast conserving surgery plus whole breast irradiation
|
| Mastectomy Patients who underwent mastectomy |
Procedure: Mastectomy
Breast mastectomy
|
Outcome Measures
Primary Outcome Measures
- Cumulative incidence of ipsilateral breast tumor recurrence [10 years]
Incidence of ipsilateral breast tumor recurrence in breast conserving surgery group compared to mastectomy group
- Cumulative incidence of axillary lymph node recurrence [10 years]
cumulative incidence of axillary lymph node recurrence in breast conserving surgery group compared to mastectomy group
- Cumulative incidence of contralateral breast cancer [10 years]
Cumulative incidence of contralateral breast cancer in breast conserving surgery group compared to mastectomy group
- Rate of distant metastasis [10 years]
Incidence of distant metastasis in breast conserving surgery group compared to mastectomy group
- Cumulative incidence of breast cancer specific survival [10 years]
Cumulative incidence of breast cancer specific survival in breast conserving surgery group compared to mastectomy group
- Rate of overall survival [10 years]
Incidence of survival in breast conserving surgery group compared to mastectomy group
Eligibility Criteria
Criteria
Inclusion Criteria:
-
First primary breast cancer
-
pT1-2
-
pN0-3a
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Surgery performed at European Institute of Oncology between 2000 and 2008
Exclusion Criteria:
-
pT>=3
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Neoadjuvant treatment
-
Presence of metastatic breast disease at the time of admission or within 3 months
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- European Institute of Oncology
Investigators
- Principal Investigator: Francesca Magnoni, MD, European Institute of Oncology
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- UID 2762