Caffeine Consumption and Cataract Prevention
Study Details
Study Description
Brief Summary
Effect of peroral caffeine consumption on the delay of cataract onset.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Several experimental studies have shown that caffeine inhibits cataract development by scavenging reactive oxygen species. Evidence from epidemiological studies, however, is controversial. Varma et al., found that the incidence of cataract blindness in humans was significantly lower in groups consuming higher amounts of coffee in comparison to the groups with lower coffee intake. Moreover, Rautiainen et al. showed that the dietary total antioxidant capacity including coffee of middle-aged and elderly women was inversely associated with the risk of age-dependent cataract. Another population-based study involving the population residing in Beaver Dam, Wisconsin, did not find a meaningful association between 10-year cumulative incidence of cataract and the amount of caffeine intake.
Although cataracts can be surgically removed, barriers that prevent access to surgery are a problem in many countries. Moreover, no prophylactic treatments are currently available to prevent the onset of cataract. Yet estimates indicate that a delay of only 10 years in the onset of cataract could reduce the need for cataract surgery by as much as 50%.
The present study aims to investigate whether peroral caffeine consumption on a regular daily basis for a significant period of time and sufficient dose delays cataract development.
12000 eyes of 6000 patients will be included into this study. Patient will have to fill out a questionnaire for caffeine consumption habits during lifetime and risk factors for cataract development. Further, a complete ophthalmic examination, cataract grading, refraction, visual testing, and biometry will be performed.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Caffeine questionnaire A questionnaire concerning caffeine habits will be handed out to the patients |
Behavioral: Questionnaire
Patients have to answer a questionnaire about their caffeine consumption habits during lifetime
|
Outcome Measures
Primary Outcome Measures
- Caffeine consumption [48 months]
Caffeine consumption will be assessed using a questionnaire concerning the caffeine drinking habits
Eligibility Criteria
Criteria
Inclusion Criteria:
-
age older than 21 years
-
cataract
Exclusion Criteria:
- age younger than 21 years
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital Vienna | Vienna | Austria | 1140 |
Sponsors and Collaborators
- Vienna Institute for Research in Ocular Surgery
Investigators
- Principal Investigator: Oliver Findl, MD, Vienna Institute for Research in Ocular Surgery (VIROS), Hanusch Hospital Vienna
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CaffQuest