Influence of Adiposity on IGF-1 and Fitness Response to Exercise in Cancer Survivors
Study Details
Study Description
Brief Summary
This is a pilot feasibility study of an investigation of the influence of excess adiposity on cardiorespiratory fitness (CRF), insulin-like growth factor-1 (IGF-1), and metabolic responses to a standardized aerobic exercise program in cancer survivors. This investigation attempts to isolate the influence of adiposity on these responses. We will enroll overweight, obese, and normal weight cancer survivors with a primary diagnosis of breast, prostate, or colorectal cancer who have completed all cancer-related treatment. Participants will engage in a 15-week aerobic exercise intervention with pre- and post-intervention assessments.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Aerobic exercise 15-week standardized aerobic exercise intervention |
Behavioral: Aerobic Exercise
A 15-week standardized aerobic exercise intervention.
Frequency: 5 days/wk (2 supervised)
Intensity: 50-59% heart rate reserve
Time: 40 min/session (ramp up from 25-40 during first 4 weeks)
Type: Aerobic exercise (e.g. treadmill, walking/jogging, cycling, elliptical)
|
Outcome Measures
Primary Outcome Measures
- Recruitment [up to 12 months]
Number of participants joining the study per month
- Study Adherence [up to 12 months]
Percentage of participants completing pre- and post-intervention assessments
- Intervention Adherence [15 weeks]
Average percentage of prescribed exercise sessions completed by participants
Secondary Outcome Measures
- Serum IGF-1 [Baseline, Week 15]
Collected via venipuncture
- Estimated VO2max [Baseline, Week 15]
Maximal oxygen consumption estimated from a 3 minute step test (Tecumseh Step Test)
- Total visceral adiposity [Baseline, Week 15]
Collected with dual-energy x-ray absorptiometry
Eligibility Criteria
Criteria
Inclusion Criteria:
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Primary cancer diagnosis of breast, prostate, or colorectal cancer
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Completion of all cancer-related treatment > than 6 months prior and < 5 years prior to enrollment
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Ability and willingness to participate in a supervised exercise program
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All participants will be required to obtain a signed physician clearance to participate in exercise form prior to enrollment
Exclusion Criteria:
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Presence of a secondary active cancer diagnosis or metastatic disease
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Any current cancer treatment (including hormonal treatment) or planned cancer treatment in the next 5 months
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Greater than 100 min of self-reported regular exercise per week
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BMI < 18.5 (underweight)
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Any significant metabolic condition, such as diabetes. Individuals with pre-diabetes or metabolic syndrome will not be excluded, but this information will be recorded.
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Any medical condition that would impact the safety of, or participation in, an exercise program or exercise testing, including:
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Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
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Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
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Pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
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Known cardiovascular disease, uncontrolled hypertension, or new cardiac event within the past 6 months
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- University of Colorado, Denver
Investigators
- Principal Investigator: Ryan Marker, University of Colorado, Denver
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 22-0356.ccc