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S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer

Sponsor
Southwest Oncology Group (Other)
Overall Status
Recruiting
CT.gov ID
NCT03418961
Collaborator
National Cancer Institute (NCI) (NIH)
817
Enrollment
580
Locations
3
Arms
135.6
Anticipated Duration (Months)
1.4
Patients Per Site
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase III trial studies how well carvedilol works in preventing cardiac toxicity in patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. A beta-blocker, such as carvedilol, is used to treat heart failure and high blood pressure, and it may prevent the heart from side effects of chemotherapy.

Condition or Disease Intervention/Treatment Phase
  • Drug: Carvedilol
  • Other: Laboratory Biomarker Analysis
  • Other: Patient Observation
 Phase 3

Detailed Description

PRIMARY OBJECTIVES:
  1. To assess whether prophylactic beta blocker therapy with carvedilol compared with no intervention reduces the risk of subsequent cardiac dysfunction in patients with metastatic breast cancer receiving trastuzumab?based HER-2 targeted therapy.
SECONDARY OBJECTIVES:

  1. To assess whether prophylactic beta blocker therapy with carvedilol compared with no intervention reduces the risk of predefined subsequent cardiac events in patients with metastatic breast cancer receiving trastuzumab?based HER-2 targeted therapy.

  2. To evaluate if prophylactic carvedilol compared with no intervention results in a longer time to first interruption of trastuzumab?based HER-2 targeted therapy due to either cardiac dysfunction or events.

  3. To assess whether prophylactic beta blocker therapy with carvedilol compared with no intervention reduces the risk of subsequent cardiac dysfunction OR events in this population.

  4. To establish and prospectively collect a predefined panel of baseline core cardiovascular measures and develop a predictive model of cardiac dysfunction.

  5. To evaluate the rate of cardiac dysfunction in an observational arm consisting of individuals otherwise eligible for the study except for use of beta blockers, angiotensin receptor blocker (ARB), or angiotensin converting enzyme (ACE) inhibitors for other medical reasons.

TERTIARY OBJECTIVES:

  1. To evaluate the isoleucine (lle) 655 valine (Val) and and alanine (Ala)ll70 proline (Pro) single nucleotide polymorphisms (SNPs) of the HER-2 gene as a predictive biomarker of study-defined cardiac dysfunction.

  2. To evaluate plasma neuregulin-1 at baseline and over study time as a predictive biomarker of study-defined cardiac dysfunction.

  3. To evaluate the feasibility of performing serial left ventricular strain in a National Clinical Trials Network (NCTN) group setting, with the goal of 75% of patients contributing both a baseline and at least one follow-up strain measurement.

  4. To bank blood for future translational medicine studies such as brain natriuretic peptide (BNP), additional SNPs, and high sensitivity troponin.

OUTLINE: Patients are randomized to 1 of 2 arms. Patients taking beta blocker, ARB, or ACE inhibitor at registration are assigned to Arm III.

ARM I: Patients not taking beta blocker, ARB, or ACE inhibitor at registration receive carvedilol orally (PO) twice daily (BID). Courses repeat every 12 weeks for 108 weeks in the absence of disease progression or unacceptable toxicity.

ARM II: Patients not taking beta blocker, ARB, or ACE inhibitor at registration receive no study intervention for up to 108 weeks.

ARM III: Patients undergo observation for up to 108 weeks.

After completion of study, patients are followed up for up to 108 weeks.

Study Design

Study Type:
Interventional
Anticipated Enrollment :
817 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Outcomes Assessor)
Primary Purpose:
Supportive Care
Official Title:
Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients With Metastatic HER-2+ Breast Cancer, Phase III
Actual Study Start Date :
Sep 15, 2017
Anticipated Primary Completion Date :
Jan 1, 2029
Anticipated Study Completion Date :
Jan 1, 2029

Arms and Interventions

Arm Intervention/Treatment
Experimental: Arm I (carvedilol)

Patients not taking beta blocker, ARB, or ACE inhibitor at registration receive carvedilol PO BID. Courses repeat every 12 weeks for 108 weeks in the absence of disease progression or unacceptable toxicity.

Drug: Carvedilol
Given PO
Other Names:
  • Coreg

    • Other: Laboratory Biomarker Analysis
    Correlative studies
    Active Comparator: Arm II (no intervention)

    Patients not taking beta blocker, ARB, or ACE inhibitor at registration receive no study intervention for up to 108 weeks.

    Other: Laboratory Biomarker Analysis
    Correlative studies
    Active Comparator: Arm III (observation)

    Patients undergo observation for up to 108 weeks.

    Other: Laboratory Biomarker Analysis
    Correlative studies

    Other: Patient Observation
    Undergo observation
    Other Names:
  • Active Surveillance
  • deferred therapy
  • expectant management
  • observation
  • Watchful Waiting

    		•

    Outcome Measures

    Primary Outcome Measures

    1. Time to the first identification of cardiac dysfunction [Up to 108 weeks]

      Real-time, blinded, central echocardiography (ECHO) read as a decrease in the left ventricular ejection fraction (LVEF) of >= 10 percentage points from baseline to a value of < 50% OR decrease of LVEF by >= 5 percentage points from baseline to LVEF < 50% in those baselines having a baseline LVEF of 50-54%. The distributions of time to cardiac dysfunction will be described using cumulative incidence estimates, with the statistical significance of treatment arm differences assessed by Cox and Fine-Gray regression models with adjustment for stratification factors. Gray's test will also be applied

    Secondary Outcome Measures

    1. Incidence of adverse events associated with beta blocker treatment [Up to 108 weeks]

      Adverse events associated with beta blocker treatment will be assessed.

    2. Rate of first interruption of trastuzumab [Up to 108 weeks]

      The distributions of time to interruption of trastuzumab-based therapy will be described using cumulative incidence estimates, with the statistical significance of treatment arm differences assessed by Cox and Fine-Gray regression models with adjustment for stratification factors. Gray?s test will also be applied to the primary endpoint to assess whether the results are sensitive to different model assumptions.

    3. Rate of death [Up to 108 weeks]

      Will compare rate of death from competing causes between treatment arms via Cox regression to evaluate whether those rates impact the primary analysis comparison.

    4. Time to first occurrence of cardiac event [Up to 108 weeks]

      any of the following treating physician documented events requiring hospitalization or medical treatment, and subsequent temporary or permanent discontinuation of trastuzumab- based HER-2 targeted therapy: arrhythmia, unstable angina, non-ST segment elevated myocardial infarction, myocardial infarction, or congestive heart failure.

    5. Drug adherence [Up to 108 weeks]

      Patients on the active arm will be asked to record study drug consumption on a monthly intake calendar. Amount of study drug taken among patients randomized to the active arm and study drug adoption among patients randomized to the no intervention arm (i.e., contamination) will be recorded by study site staff on a case report form at each follow-up visit to assess the sensitivity of the primary treatment effect to observed conditions.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • STEP 1 REGISTRATION

    • Patients must have metastatic breast cancer and be initiating within 7 days of step 1 registration or continuing trastuzumab?based HER-2 targeted therapy without concurrent anthracyclines in first or second line setting; patients may have brain metastasis; there is no limit for number of doses of HER-2 targeted therapy prior to registration; examples of eligible HER-2 targeted therapy:

    • Trastuzumab

    • Trastuzumab + chemotherapy or hormonal therapy

    • Trastuzumab + other HER-2 targeted agent with or without chemotherapy (such as pertuzumab)

    • Ado-trastuzumab (Kadcyla)

    • NOTE: Patients on lapatinib without trastuzumab are not eligible; planned treatment with concurrent HER-2 targeted therapy and anthracyclines is not permitted

    • Patients must be at increased risk for cardiotoxicity defined by at least one of the following:

    • Previous anthracycline exposure, OR

    • 1 or more of the following risk factors for heart disease:

    • Left ventricular ejection fraction (LVEF) 50-54% by local echocardiography (ECHO) read

    • Age >= 65

    • Body mass index (BMI) >= 30 kg/m^2

    • Current or prior anti-hypertensive therapy

    • Diagnosis of coronary artery disease (CAD)

    • Diabetes mellitus

    • Atrial fibrillation/flutter

    • Patients must not have taken within 21 days prior to step 1 registration, be currently taking at the time of step 1 registration, or planning to take once registered to step 1 a beta blocker, ARB, or ACE inhibitor in order to be randomized (Arms 1 and 2)

    • Patients currently taking a beta blocker, ARB, or ACE inhibitor at the time of step 1 registration are eligible to register for the non-randomized observational cohort (Arm 3)

    • Patients must not be currently taking or planning to take during study treatment the following medications:

    • B2 agonists

    • Bosutinib

    • Ceritinib

    • Floctafenine

    • Methacholine

    • Pazopanib

    • Rivastigmine

    • Vincristine

    • Silodosin

    • Patients must have a Zubrod Performance status of 0-2

    • Patients must have a complete physical examination and medical history within 28 days prior to registration

    • Patients must have LVEF >= 50% by 2-dimensional (D) echocardiogram within 28 days prior to registration; the echocardiogram must be obtained from a S1501 validated ECHO laboratory (lab) and submitted for central review by the S1501 ECHO core lab; ECHO should not be submitted for central read until patient has been otherwise deemed eligible

    • Serum bilirubin < 3.0 x institutional upper limit of normal (IULN)

    • Serum glutamic oxaloacetic transaminase (SGOT)/aspartate aminotransferase (AST) and serum glutamic pyruvic transaminase (SGPT)/alanine aminotransferase (ALT) < 5.0 x IULN

    • Patients must have electrocardiogram with corrected QT (QTc) with correction within 28 days prior to registration

    • Patients must have a systolic blood pressure >= 80 mm Hg within 14 days prior to registration

    • Patients must not be dialysis dependent

    • Patients must be able to swallow tablets

    • Patients must not have uncontrolled asthma

    • Patients must not co-enroll on other treatment trials

    • No other prior malignancy is allowed except for the following: adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, prostate cancer on active surveillance, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease free for five years

    • Patients must not be pregnant or nursing due to potential fetal or nursing infant harm; women/men of reproductive potential must have agreed to use an effective contraceptive method, a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures

    • Patients must be willing to submit blood specimens

    • Sites must seek additional patient consent for the future use of specimens

    • Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines

    • As a part of the OPEN registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

    • STEP 2 REGISTRATION (Randomization)

    • Patients must not be registered to step 2 until receiving confirmation from the ECHO Core Lab that the patient?s LVEF by echocardiogram was >= 50% by central review; patients must be registered within 5 calendar days of receiving the e-mail notification

    • Site must verify that there is no known change in the step 1 eligibility since initial registration

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Anchorage Associates in Radiation Medicine Anchorage Alaska United States 98508
    2 Alaska Breast Care and Surgery LLC Anchorage Alaska United States 99508
    3 Alaska Oncology and Hematology LLC Anchorage Alaska United States 99508
    4 Alaska Women's Cancer Care Anchorage Alaska United States 99508
    5 Anchorage Oncology Centre Anchorage Alaska United States 99508
    6 Katmai Oncology Group Anchorage Alaska United States 99508
    7 Providence Alaska Medical Center Anchorage Alaska United States 99508
    8 Fairbanks Memorial Hospital Fairbanks Alaska United States 99701
    9 CHI Saint Vincent Cancer Center Hot Springs Hot Springs Arkansas United States 71913
    10 Kaiser Permanente-Deer Valley Medical Center Antioch California United States 94531
    11 Providence Saint Joseph Medical Center/Disney Family Cancer Center Burbank California United States 91505
    12 Enloe Medical Center Chico California United States 95926
    13 City of Hope Comprehensive Cancer Center Duarte California United States 91010
    14 Epic Care-Dublin Dublin California United States 94568
    15 Bay Area Breast Surgeons Inc Emeryville California United States 94608
    16 Epic Care Partners in Cancer Care Emeryville California United States 94608
    17 Kaiser Permanente-Fremont Fremont California United States 94538
    18 Fresno Cancer Center Fresno California United States 93720
    19 Kaiser Permanente-Fresno Fresno California United States 93720
    20 USC / Norris Comprehensive Cancer Center Los Angeles California United States 90033
    21 Contra Costa Regional Medical Center Martinez California United States 94553-3156
    22 City of Hope Mission Hills Mission Hills California United States 91345
    23 Kaiser Permanente-Modesto Modesto California United States 95356
    24 City of Hope Newport Beach Newport Beach California United States 92660
    25 Alta Bates Summit Medical Center - Summit Campus Oakland California United States 94609
    26 Bay Area Tumor Institute Oakland California United States 94609
    27 Kaiser Permanente Oakland-Broadway Oakland California United States 94611
    28 Kaiser Permanente-Oakland Oakland California United States 94611
    29 Kaiser Permanente-Rancho Cordova Cancer Center Rancho Cordova California United States 95670
    30 Kaiser Permanente-Redwood City Redwood City California United States 94063
    31 Kaiser Permanente-Richmond Richmond California United States 94801
    32 Rohnert Park Cancer Center Rohnert Park California United States 94928
    33 Kaiser Permanente-Roseville Roseville California United States 95661
    34 The Permanente Medical Group-Roseville Radiation Oncology Roseville California United States 95678
    35 University of California Davis Comprehensive Cancer Center Sacramento California United States 95817
    36 Kaiser Permanente-South Sacramento Sacramento California United States 95823
    37 South Sacramento Cancer Center Sacramento California United States 95823
    38 Kaiser Permanente - Sacramento Sacramento California United States 95825
    39 Kaiser Permanente-San Francisco San Francisco California United States 94115
    40 Kaiser Permanente-Santa Teresa-San Jose San Jose California United States 95119
    41 Kaiser Permanente San Leandro San Leandro California United States 94577
    42 Kaiser Permanente-San Rafael San Rafael California United States 94903
    43 Kaiser San Rafael-Gallinas San Rafael California United States 94903
    44 Kaiser Permanente Medical Center - Santa Clara Santa Clara California United States 95051
    45 Kaiser Permanente-Santa Rosa Santa Rosa California United States 95403
    46 City of Hope South Pasadena South Pasadena California United States 91030
    47 Kaiser Permanente Cancer Treatment Center South San Francisco California United States 94080
    48 Kaiser Permanente-South San Francisco South San Francisco California United States 94080
    49 Kaiser Permanente-Stockton Stockton California United States 95210
    50 City of Hope Upland Upland California United States 91786
    51 Kaiser Permanente Medical Center-Vacaville Vacaville California United States 95688
    52 Kaiser Permanente-Vallejo Vallejo California United States 94589
    53 Kaiser Permanente-Walnut Creek Walnut Creek California United States 94596
    54 Penrose-Saint Francis Healthcare Colorado Springs Colorado United States 80907
    55 Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado United States 80907
    56 Kaiser Permanente-Franklin Denver Colorado United States 80205
    57 Porter Adventist Hospital Denver Colorado United States 80210
    58 SCL Health Saint Joseph Hospital Denver Colorado United States 80218
    59 Mercy Medical Center Durango Colorado United States 81301
    60 Southwest Oncology PC Durango Colorado United States 81301
    61 Mountain Blue Cancer Care Center Golden Colorado United States 80401
    62 Good Samaritan Medical Center Lafayette Colorado United States 80026
    63 Kaiser Permanente-Rock Creek Lafayette Colorado United States 80026
    64 Rocky Mountain Cancer Centers-Lakewood Lakewood Colorado United States 80228
    65 Saint Anthony Hospital Lakewood Colorado United States 80228
    66 Littleton Adventist Hospital Littleton Colorado United States 80122
    67 Kaiser Permanente-Lone Tree Lone Tree Colorado United States 80124
    68 Longmont United Hospital Longmont Colorado United States 80501
    69 Rocky Mountain Cancer Centers-Longmont Longmont Colorado United States 80501
    70 Parker Adventist Hospital Parker Colorado United States 80138
    71 Rocky Mountain Cancer Centers-Parker Parker Colorado United States 80138
    72 Saint Mary Corwin Medical Center Pueblo Colorado United States 81004
    73 Rocky Mountain Cancer Centers - Pueblo Pueblo Colorado United States 81008
    74 Rocky Mountain Cancer Centers-Thornton Thornton Colorado United States 80260
    75 Middlesex Hospital Middletown Connecticut United States 06457
    76 Stamford Hospital/Bennett Cancer Center Stamford Connecticut United States 06904
    77 Bayhealth Hospital Kent Campus Dover Delaware United States 19901
    78 Beebe South Coastal Health Campus Frankford Delaware United States 19945
    79 Beebe Medical Center Lewes Delaware United States 19958
    80 Delaware Clinical and Laboratory Physicians PA Newark Delaware United States 19713
    81 Helen F Graham Cancer Center Newark Delaware United States 19713
    82 Medical Oncology Hematology Consultants PA Newark Delaware United States 19713
    83 Christiana Care Health System-Christiana Hospital Newark Delaware United States 19718
    84 Beebe Health Campus Rehoboth Beach Delaware United States 19971
    85 TidalHealth Nanticoke / Allen Cancer Center Seaford Delaware United States 19973
    86 Christiana Care Health System-Wilmington Hospital Wilmington Delaware United States 19801
    87 Broward Health Medical Center Fort Lauderdale Florida United States 33316
    88 Mount Sinai Medical Center Miami Beach Florida United States 33140
    89 Moffitt Cancer Center Tampa Florida United States 33612
    90 Cleveland Clinic-Weston Weston Florida United States 33331
    91 Emory University Hospital Midtown Atlanta Georgia United States 30308
    92 Emory University Hospital/Winship Cancer Institute Atlanta Georgia United States 30322
    93 Emory Saint Joseph's Hospital Atlanta Georgia United States 30342
    94 Northside Hospital Atlanta Georgia United States 30342
    95 John B Amos Cancer Center Columbus Georgia United States 31904
    96 Northeast Georgia Medical Center-Gainesville Gainesville Georgia United States 30501
    97 Low Country Cancer Care Savannah Georgia United States 31404
    98 Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia United States 31405
    99 Summit Cancer Care-Candler Savannah Georgia United States 31405
    100 Lewis Hall Singletary Oncology Center Thomasville Georgia United States 31792
    101 Pali Momi Medical Center 'Aiea Hawaii United States 96701
    102 Queen's Cancer Center - Pearlridge 'Aiea Hawaii United States 96701
    103 The Cancer Center of Hawaii-Pali Momi 'Aiea Hawaii United States 96701
    104 Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii United States 96813
    105 Island Urology Honolulu Hawaii United States 96813
    106 Queen's Cancer Cenrer - POB I Honolulu Hawaii United States 96813
    107 Queen's Medical Center Honolulu Hawaii United States 96813
    108 Straub Clinic and Hospital Honolulu Hawaii United States 96813
    109 University of Hawaii Cancer Center Honolulu Hawaii United States 96813
    110 Hawaii Cancer Care Inc-Liliha Honolulu Hawaii United States 96817
    111 Kuakini Medical Center Honolulu Hawaii United States 96817
    112 Queen's Cancer Center - Kuakini Honolulu Hawaii United States 96817
    113 The Cancer Center of Hawaii-Liliha Honolulu Hawaii United States 96817
    114 Kaiser Permanente Moanalua Medical Center Honolulu Hawaii United States 96819
    115 Kapiolani Medical Center for Women and Children Honolulu Hawaii United States 96826
    116 Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii United States 96766
    117 Saint Alphonsus Cancer Care Center-Boise Boise Idaho United States 83706
    118 Saint Luke's Cancer Institute - Boise Boise Idaho United States 83712
    119 Saint Alphonsus Cancer Care Center-Caldwell Caldwell Idaho United States 83605
    120 Kootenai Health - Coeur d'Alene Coeur d'Alene Idaho United States 83814
    121 Walter Knox Memorial Hospital Emmett Idaho United States 83617
    122 Saint Luke's Cancer Institute - Fruitland Fruitland Idaho United States 83619
    123 Idaho Urologic Institute-Meridian Meridian Idaho United States 83642
    124 Saint Luke's Cancer Institute - Meridian Meridian Idaho United States 83642
    125 Saint Alphonsus Medical Center-Nampa Nampa Idaho United States 83686
    126 Saint Luke's Cancer Institute - Nampa Nampa Idaho United States 83686
    127 Kootenai Clinic Cancer Services - Post Falls Post Falls Idaho United States 83854
    128 Kootenai Cancer Clinic Sandpoint Idaho United States 83864
    129 Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho United States 83301
    130 Rush - Copley Medical Center Aurora Illinois United States 60504
    131 Illinois CancerCare-Bloomington Bloomington Illinois United States 61704
    132 Illinois CancerCare-Canton Canton Illinois United States 61520
    133 Memorial Hospital of Carbondale Carbondale Illinois United States 62902
    134 SIH Cancer Institute Carterville Illinois United States 62918
    135 Illinois CancerCare-Carthage Carthage Illinois United States 62321
    136 Centralia Oncology Clinic Centralia Illinois United States 62801
    137 John H Stroger Jr Hospital of Cook County Chicago Illinois United States 60612
    138 University of Illinois Chicago Illinois United States 60612
    139 Carle on Vermilion Danville Illinois United States 61832
    140 Cancer Care Specialists of Illinois - Decatur Decatur Illinois United States 62526
    141 Decatur Memorial Hospital Decatur Illinois United States 62526
    142 Carle Physician Group-Effingham Effingham Illinois United States 62401
    143 Crossroads Cancer Center Effingham Illinois United States 62401
    144 Illinois CancerCare-Eureka Eureka Illinois United States 61530
    145 Illinois CancerCare-Galesburg Galesburg Illinois United States 61401
    146 Western Illinois Cancer Treatment Center Galesburg Illinois United States 61401
    147 Illinois CancerCare-Kewanee Clinic Kewanee Illinois United States 61443
    148 Illinois CancerCare-Macomb Macomb Illinois United States 61455
    149 Carle Physician Group-Mattoon/Charleston Mattoon Illinois United States 61938
    150 Loyola University Medical Center Maywood Illinois United States 60153
    151 Good Samaritan Regional Health Center Mount Vernon Illinois United States 62864
    152 Cancer Care Center of O'Fallon O'Fallon Illinois United States 62269
    153 Illinois CancerCare-Ottawa Clinic Ottawa Illinois United States 61350
    154 Illinois CancerCare-Pekin Pekin Illinois United States 61554
    155 OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center Pekin Illinois United States 61554
    156 Illinois CancerCare-Peoria Peoria Illinois United States 61615
    157 OSF Saint Francis Radiation Oncology at Peoria Cancer Center Peoria Illinois United States 61615
    158 Methodist Medical Center of Illinois Peoria Illinois United States 61636
    159 OSF Saint Francis Medical Center Peoria Illinois United States 61637
    160 Illinois CancerCare-Peru Peru Illinois United States 61354
    161 Valley Radiation Oncology Peru Illinois United States 61354
    162 Illinois CancerCare-Princeton Princeton Illinois United States 61356
    163 Southern Illinois University School of Medicine Springfield Illinois United States 62702
    164 Springfield Clinic Springfield Illinois United States 62702
    165 Memorial Medical Center Springfield Illinois United States 62781
    166 Southwest Illinois Health Services LLP Swansea Illinois United States 62226
    167 Carle Cancer Center Urbana Illinois United States 61801
    168 The Carle Foundation Hospital Urbana Illinois United States 61801
    169 Rush-Copley Healthcare Center Yorkville Illinois United States 60560
    170 Franciscan Health Indianapolis Indianapolis Indiana United States 46237
    171 Franciscan Saint Elizabeth Health - Lafayette East Lafayette Indiana United States 47905
    172 Franciscan Health Mooresville Mooresville Indiana United States 46158
    173 Reid Health Richmond Indiana United States 47374
    174 Union Hospital Terre Haute Indiana United States 47804
    175 Medical Oncology and Hematology Associates-West Des Moines Clive Iowa United States 50325
    176 Mercy Cancer Center-West Lakes Clive Iowa United States 50325
    177 Alegent Health Mercy Hospital Council Bluffs Iowa United States 51503
    178 Greater Regional Medical Center Creston Iowa United States 50801
    179 Iowa Methodist Medical Center Des Moines Iowa United States 50309
    180 Medical Oncology and Hematology Associates-Des Moines Des Moines Iowa United States 50309
    181 Broadlawns Medical Center Des Moines Iowa United States 50314
    182 Medical Oncology and Hematology Associates-Laurel Des Moines Iowa United States 50314
    183 Mercy Medical Center - Des Moines Des Moines Iowa United States 50314
    184 Iowa Lutheran Hospital Des Moines Iowa United States 50316
    185 Methodist West Hospital West Des Moines Iowa United States 50266-7700
    186 Mercy Medical Center-West Lakes West Des Moines Iowa United States 50266
    187 Coffeyville Regional Medical Center Coffeyville Kansas United States 67337
    188 Central Care Cancer Center - Garden City Garden City Kansas United States 67846
    189 Saint Catherine Hospital Garden City Kansas United States 67846
    190 Central Care Cancer Center - Great Bend Great Bend Kansas United States 67530
    191 HaysMed University of Kansas Health System Hays Kansas United States 67601
    192 University of Kansas Cancer Center-West Kansas City Kansas United States 66112
    193 University of Kansas Cancer Center Kansas City Kansas United States 66160
    194 Kansas Institute of Medicine Cancer and Blood Center Lenexa Kansas United States 66219
    195 Minimally Invasive Surgery Hospital Lenexa Kansas United States 66219
    196 Olathe Health Cancer Center Olathe Kansas United States 66061
    197 Menorah Medical Center Overland Park Kansas United States 66209
    198 University of Kansas Cancer Center-Overland Park Overland Park Kansas United States 66210
    199 University of Kansas Hospital-Indian Creek Campus Overland Park Kansas United States 66211
    200 Saint Luke's South Hospital Overland Park Kansas United States 66213
    201 Ascension Via Christi - Pittsburg Pittsburg Kansas United States 66762
    202 Salina Regional Health Center Salina Kansas United States 67401
    203 University of Kansas Health System Saint Francis Campus Topeka Kansas United States 66606
    204 University of Kansas Hospital-Westwood Cancer Center Westwood Kansas United States 66205
    205 Flaget Memorial Hospital Bardstown Kentucky United States 40004
    206 Commonwealth Cancer Center-Corbin Corbin Kentucky United States 40701
    207 Saint Joseph Radiation Oncology Resource Center Lexington Kentucky United States 40504
    208 Saint Joseph Hospital East Lexington Kentucky United States 40509
    209 Saint Joseph London London Kentucky United States 40741
    210 Jewish Hospital Louisville Kentucky United States 40202
    211 Saints Mary and Elizabeth Hospital Louisville Kentucky United States 40215
    212 Jewish Hospital Medical Center Northeast Louisville Kentucky United States 40245
    213 Jewish Hospital Medical Center South Shepherdsville Kentucky United States 40165
    214 LSU Health Baton Rouge-North Clinic Baton Rouge Louisiana United States 70805
    215 Louisiana Hematology Oncology Associates LLC Baton Rouge Louisiana United States 70809
    216 Mary Bird Perkins Cancer Center Baton Rouge Louisiana United States 70809
    217 Ochsner Health Center-Summa Baton Rouge Louisiana United States 70809
    218 Our Lady of the Lake Physicians Group - Medical Oncology Baton Rouge Louisiana United States 70809
    219 Medical Center of Baton Rouge Baton Rouge Louisiana United States 70816
    220 Louisiana Hematology Oncology Associates Baton Rouge Louisiana United States 70817
    221 Our Lady of the Lake Medical Oncology Baton Rouge Louisiana United States 70817
    222 Woman's Hospital Baton Rouge Louisiana United States 70817
    223 Ochsner Hematology Oncology North Shore - Covington (West Region) Covington Louisiana United States 70433
    224 Ochsner Medical Center Jefferson New Orleans Louisiana United States 70121
    225 LSU Health Sciences Center at Shreveport Shreveport Louisiana United States 71103
    226 UM Upper Chesapeake Medical Center Bel Air Maryland United States 21014
    227 Lahey Hospital and Medical Center Burlington Massachusetts United States 01805
    228 Winchester Hospital Winchester Massachusetts United States 01890
    229 Saint Joseph Mercy Hospital Ann Arbor Michigan United States 48106
    230 University of Michigan Comprehensive Cancer Center Ann Arbor Michigan United States 48109
    231 Bronson Battle Creek Battle Creek Michigan United States 49017
    232 McLaren Cancer Institute-Bay City Bay City Michigan United States 48706
    233 McLaren Cancer Institute-Bloomfield Bloomfield Michigan United States 48302
    234 IHA Hematology Oncology Consultants-Brighton Brighton Michigan United States 48114
    235 Saint Joseph Mercy Brighton Brighton Michigan United States 48114
    236 Henry Ford Cancer Institute-Downriver Brownstown Michigan United States 48183
    237 IHA Hematology Oncology Consultants-Canton Canton Michigan United States 48188
    238 Saint Joseph Mercy Canton Canton Michigan United States 48188
    239 Caro Cancer Center Caro Michigan United States 48723
    240 IHA Hematology Oncology Consultants-Chelsea Chelsea Michigan United States 48118
    241 Saint Joseph Mercy Chelsea Chelsea Michigan United States 48118
    242 Hematology Oncology Consultants-Clarkston Clarkston Michigan United States 48346
    243 McLaren Cancer Institute-Clarkston Clarkston Michigan United States 48346
    244 Newland Medical Associates-Clarkston Clarkston Michigan United States 48346
    245 Henry Ford Macomb Hospital-Clinton Township Clinton Township Michigan United States 48038
    246 Henry Ford Medical Center-Fairlane Dearborn Michigan United States 48126
    247 Wayne State University/Karmanos Cancer Institute Detroit Michigan United States 48201
    248 Henry Ford Hospital Detroit Michigan United States 48202
    249 Ascension Saint John Hospital Detroit Michigan United States 48236
    250 Great Lakes Cancer Management Specialists-Doctors Park East China Township Michigan United States 48054
    251 Genesee Cancer and Blood Disease Treatment Center Flint Michigan United States 48503
    252 Genesee Hematology Oncology PC Flint Michigan United States 48503
    253 Genesys Hurley Cancer Institute Flint Michigan United States 48503
    254 Hurley Medical Center Flint Michigan United States 48503
    255 McLaren Cancer Institute-Flint Flint Michigan United States 48532
    256 Singh and Arora Hematology Oncology PC Flint Michigan United States 48532
    257 Mercy Health Saint Mary's Grand Rapids Michigan United States 49503
    258 Spectrum Health at Butterworth Campus Grand Rapids Michigan United States 49503
    259 Academic Hematology Oncology Specialists Grosse Pointe Woods Michigan United States 48236
    260 Great Lakes Cancer Management Specialists-Van Elslander Cancer Center Grosse Pointe Woods Michigan United States 48236
    261 Michigan Breast Specialists-Grosse Pointe Woods Grosse Pointe Woods Michigan United States 48236
    262 Allegiance Health Jackson Michigan United States 49201
    263 Bronson Methodist Hospital Kalamazoo Michigan United States 49007
    264 West Michigan Cancer Center Kalamazoo Michigan United States 49007
    265 Borgess Medical Center Kalamazoo Michigan United States 49048
    266 McLaren-Greater Lansing Lansing Michigan United States 48910
    267 Sparrow Hospital Lansing Michigan United States 48912
    268 McLaren Cancer Institute-Lapeer Region Lapeer Michigan United States 48446
    269 Hope Cancer Clinic Livonia Michigan United States 48154
    270 Saint Mary Mercy Hospital Livonia Michigan United States 48154
    271 Great Lakes Cancer Management Specialists-Macomb Medical Campus Macomb Michigan United States 48044
    272 Michigan Breast Specialists-Macomb Township Macomb Michigan United States 48044
    273 Saint Mary's Oncology/Hematology Associates of Marlette Marlette Michigan United States 48453
    274 McLaren Cancer Institute-Macomb Mount Clemens Michigan United States 48043
    275 Mercy Health Mercy Campus Muskegon Michigan United States 49444
    276 Lakeland Hospital Niles Niles Michigan United States 49120
    277 Ascension Providence Hospitals - Novi Novi Michigan United States 48374
    278 Henry Ford Medical Center-Columbus Novi Michigan United States 48377
    279 21st Century Oncology-Pontiac Pontiac Michigan United States 48341
    280 Hope Cancer Center Pontiac Michigan United States 48341
    281 Newland Medical Associates-Pontiac Pontiac Michigan United States 48341
    282 Saint Joseph Mercy Oakland Pontiac Michigan United States 48341
    283 Spectrum Health Reed City Hospital Reed City Michigan United States 49677
    284 Great Lakes Cancer Management Specialists-Rochester Hills Rochester Hills Michigan United States 48309
    285 Ascension Saint Mary's Hospital Saginaw Michigan United States 48601
    286 Oncology Hematology Associates of Saginaw Valley PC Saginaw Michigan United States 48604
    287 Lakeland Medical Center Saint Joseph Saint Joseph Michigan United States 49085
    288 Marie Yeager Cancer Center Saint Joseph Michigan United States 49085
    289 Ascension Providence Hospitals - Southfield Southfield Michigan United States 48075
    290 Bhadresh Nayak MD PC-Sterling Heights Sterling Heights Michigan United States 48312
    291 Ascension Saint Joseph Hospital Tawas City Michigan United States 48764
    292 Munson Medical Center Traverse City Michigan United States 49684
    293 Advanced Breast Care Center PLLC Warren Michigan United States 48088
    294 Great Lakes Cancer Management Specialists-Macomb Professional Building Warren Michigan United States 48093
    295 Macomb Hematology Oncology PC Warren Michigan United States 48093
    296 Michigan Breast Specialists-Warren Warren Michigan United States 48093
    297 Saint John Macomb-Oakland Hospital Warren Michigan United States 48093
    298 Henry Ford West Bloomfield Hospital West Bloomfield Michigan United States 48322
    299 Saint Mary's Oncology/Hematology Associates of West Branch West Branch Michigan United States 48661
    300 Metro Health Hospital Wyoming Michigan United States 49519
    301 Huron Gastroenterology PC Ypsilanti Michigan United States 48106
    302 IHA Hematology Oncology Consultants-Ann Arbor Ypsilanti Michigan United States 48197
    303 Sanford Joe Lueken Cancer Center Bemidji Minnesota United States 56601
    304 Essentia Health Saint Joseph's Medical Center Brainerd Minnesota United States 56401
    305 Fairview Ridges Hospital Burnsville Minnesota United States 55337
    306 Mercy Hospital Coon Rapids Minnesota United States 55433
    307 Essentia Health Cancer Center Duluth Minnesota United States 55805
    308 Essentia Health Saint Mary's Medical Center Duluth Minnesota United States 55805
    309 Miller-Dwan Hospital Duluth Minnesota United States 55805
    310 Fairview Southdale Hospital Edina Minnesota United States 55435
    311 Lake Region Healthcare Corporation-Cancer Care Fergus Falls Minnesota United States 56537
    312 Unity Hospital Fridley Minnesota United States 55432
    313 Essentia Health Hibbing Clinic Hibbing Minnesota United States 55746
    314 Fairview Clinics and Surgery Center Maple Grove Maple Grove Minnesota United States 55369
    315 Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota United States 55109
    316 Saint John's Hospital - Healtheast Maplewood Minnesota United States 55109
    317 Abbott-Northwestern Hospital Minneapolis Minnesota United States 55407
    318 Hennepin County Medical Center Minneapolis Minnesota United States 55415
    319 Health Partners Inc Minneapolis Minnesota United States 55454
    320 Monticello Cancer Center Monticello Minnesota United States 55362
    321 New Ulm Medical Center New Ulm Minnesota United States 56073
    322 North Memorial Medical Health Center Robbinsdale Minnesota United States 55422
    323 Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota United States 55416
    324 Regions Hospital Saint Paul Minnesota United States 55101
    325 United Hospital Saint Paul Minnesota United States 55102
    326 Saint Francis Regional Medical Center Shakopee Minnesota United States 55379
    327 Lakeview Hospital Stillwater Minnesota United States 55082
    328 Essentia Health Virginia Clinic Virginia Minnesota United States 55792
    329 Ridgeview Medical Center Waconia Minnesota United States 55387
    330 Rice Memorial Hospital Willmar Minnesota United States 56201
    331 Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota United States 55125
    332 Fairview Lakes Medical Center Wyoming Minnesota United States 55092
    333 Baptist Memorial Hospital and Cancer Center-Golden Triangle Columbus Mississippi United States 39705
    334 Baptist Cancer Center-Grenada Grenada Mississippi United States 38901
    335 University of Mississippi Medical Center Jackson Mississippi United States 39216
    336 Baptist Memorial Hospital and Cancer Center-Union County New Albany Mississippi United States 38652
    337 Baptist Memorial Hospital and Cancer Center-Oxford Oxford Mississippi United States 38655
    338 Singing River Hospital Pascagoula Mississippi United States 39581
    339 Baptist Memorial Hospital and Cancer Center-Desoto Southhaven Mississippi United States 38671
    340 Saint Louis Cancer and Breast Institute-Ballwin Ballwin Missouri United States 63011
    341 Central Care Cancer Center - Bolivar Bolivar Missouri United States 65613
    342 Parkland Health Center-Bonne Terre Bonne Terre Missouri United States 63628
    343 Cox Cancer Center Branson Branson Missouri United States 65616
    344 Saint Francis Medical Center Cape Girardeau Missouri United States 63703
    345 Southeast Cancer Center Cape Girardeau Missouri United States 63703
    346 Siteman Cancer Center at West County Hospital Creve Coeur Missouri United States 63141
    347 Centerpoint Medical Center LLC Independence Missouri United States 64057
    348 Capital Region Southwest Campus Jefferson City Missouri United States 65109
    349 Freeman Health System Joplin Missouri United States 64804
    350 Mercy Hospital Joplin Joplin Missouri United States 64804
    351 Truman Medical Centers Kansas City Missouri United States 64108
    352 Saint Luke's Hospital of Kansas City Kansas City Missouri United States 64111
    353 Research Medical Center Kansas City Missouri United States 64132
    354 University of Kansas Cancer Center - North Kansas City Missouri United States 64154
    355 University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri United States 64064
    356 Saint Luke's East - Lee's Summit Lee's Summit Missouri United States 64086
    357 University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri United States 64116
    358 Delbert Day Cancer Institute at PCRMC Rolla Missouri United States 65401
    359 Mercy Clinic-Rolla-Cancer and Hematology Rolla Missouri United States 65401
    360 Heartland Regional Medical Center Saint Joseph Missouri United States 64506
    361 Saint Louis Cancer and Breast Institute-South City Saint Louis Missouri United States 63109
    362 Washington University School of Medicine Saint Louis Missouri United States 63110
    363 Mercy Hospital South Saint Louis Missouri United States 63128
    364 Siteman Cancer Center-South County Saint Louis Missouri United States 63129
    365 Missouri Baptist Medical Center Saint Louis Missouri United States 63131
    366 Siteman Cancer Center at Christian Hospital Saint Louis Missouri United States 63136
    367 Mercy Hospital Saint Louis Saint Louis Missouri United States 63141
    368 Siteman Cancer Center at Saint Peters Hospital Saint Peters Missouri United States 63376
    369 Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri United States 63670
    370 Mercy Hospital Springfield Springfield Missouri United States 65804
    371 CoxHealth South Hospital Springfield Missouri United States 65807
    372 Missouri Baptist Sullivan Hospital Sullivan Missouri United States 63080
    373 Missouri Baptist Outpatient Center-Sunset Hills Sunset Hills Missouri United States 63127
    374 Mercy Hospital Washington Washington Missouri United States 63090
    375 Community Hospital of Anaconda Anaconda Montana United States 59711
    376 Billings Clinic Cancer Center Billings Montana United States 59101
    377 Bozeman Deaconess Hospital Bozeman Montana United States 59715
    378 Benefis Healthcare- Sletten Cancer Institute Great Falls Montana United States 59405
    379 Great Falls Clinic Great Falls Montana United States 59405
    380 Saint Peter's Community Hospital Helena Montana United States 59601
    381 Kalispell Regional Medical Center Kalispell Montana United States 59901
    382 Saint Patrick Hospital - Community Hospital Missoula Montana United States 59802
    383 Community Medical Hospital Missoula Montana United States 59804
    384 CHI Health Saint Francis Grand Island Nebraska United States 68803
    385 Heartland Hematology and Oncology Kearney Nebraska United States 68845
    386 CHI Health Good Samaritan Kearney Nebraska United States 68847
    387 Saint Elizabeth Regional Medical Center Lincoln Nebraska United States 68510
    388 Alegent Health Immanuel Medical Center Omaha Nebraska United States 68122
    389 Hematology and Oncology Consultants PC Omaha Nebraska United States 68122
    390 Alegent Health Bergan Mercy Medical Center Omaha Nebraska United States 68124
    391 Alegent Health Lakeside Hospital Omaha Nebraska United States 68130
    392 Creighton University Medical Center Omaha Nebraska United States 68131
    393 Midlands Community Hospital Papillion Nebraska United States 68046
    394 Morristown Medical Center Morristown New Jersey United States 07960
    395 Newton Medical Center Newton New Jersey United States 07860
    396 Robert Wood Johnson University Hospital Somerset Somerville New Jersey United States 08876
    397 Overlook Hospital Summit New Jersey United States 07902
    398 Holy Name Hospital Teaneck New Jersey United States 07666
    399 University of New Mexico Cancer Center Albuquerque New Mexico United States 87102
    400 NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center New York New York United States 10032
    401 Nyack Hospital Nyack New York United States 10960
    402 Stony Brook University Medical Center Stony Brook New York United States 11794
    403 Southeastern Medical Oncology Center-Clinton Clinton North Carolina United States 28328
    404 Southeastern Medical Oncology Center-Goldsboro Goldsboro North Carolina United States 27534
    405 Wayne Memorial Hospital Goldsboro North Carolina United States 27534
    406 Onslow Memorial Hospital Jacksonville North Carolina United States 28546
    407 Southeastern Medical Oncology Center-Jacksonville Jacksonville North Carolina United States 28546
    408 Sanford Bismarck Medical Center Bismarck North Dakota United States 58501
    409 Essentia Health Cancer Center-South University Clinic Fargo North Dakota United States 58103
    410 Sanford Broadway Medical Center Fargo North Dakota United States 58122
    411 Sanford Roger Maris Cancer Center Fargo North Dakota United States 58122
    412 Cleveland Clinic Akron General Akron Ohio United States 44307
    413 UHHS-Chagrin Highlands Medical Center Beachwood Ohio United States 44122
    414 Indu and Raj Soin Medical Center Beavercreek Ohio United States 45431
    415 Aultman Health Foundation Canton Ohio United States 44710
    416 Dayton Physicians LLC-Miami Valley South Centerville Ohio United States 45459
    417 Miami Valley Hospital South Centerville Ohio United States 45459
    418 Geauga Hospital Chardon Ohio United States 44024
    419 The Christ Hospital Cincinnati Ohio United States 45219
    420 University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio United States 45219
    421 Good Samaritan Hospital - Cincinnati Cincinnati Ohio United States 45220
    422 Oncology Hematology Care Inc-Kenwood Cincinnati Ohio United States 45236
    423 Bethesda North Hospital Cincinnati Ohio United States 45242
    424 TriHealth Cancer Institute-Westside Cincinnati Ohio United States 45247
    425 TriHealth Cancer Institute-Anderson Cincinnati Ohio United States 45255
    426 Case Western Reserve University Cleveland Ohio United States 44106
    427 Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio United States 44111
    428 Cleveland Clinic Foundation Cleveland Ohio United States 44195
    429 Good Samaritan Hospital - Dayton Dayton Ohio United States 45406
    430 Miami Valley Hospital Dayton Ohio United States 45409
    431 Dayton Physician LLC-Miami Valley Hospital North Dayton Ohio United States 45415
    432 Miami Valley Hospital North Dayton Ohio United States 45415
    433 Mercy Cancer Center-Elyria Elyria Ohio United States 44035
    434 Armes Family Cancer Center Findlay Ohio United States 45840
    435 Blanchard Valley Hospital Findlay Ohio United States 45840
    436 Orion Cancer Care Findlay Ohio United States 45840
    437 Atrium Medical Center-Middletown Regional Hospital Franklin Ohio United States 45005-1066
    438 Dayton Physicians LLC-Atrium Franklin Ohio United States 45005
    439 Dayton Physicians LLC-Wayne Greenville Ohio United States 45331
    440 Wayne Hospital Greenville Ohio United States 45331
    441 Cleveland Clinic Cancer Center Independence Independence Ohio United States 44131
    442 Greater Dayton Cancer Center Kettering Ohio United States 45409
    443 First Dayton Cancer Care Kettering Ohio United States 45420
    444 Kettering Medical Center Kettering Ohio United States 45429
    445 Cleveland Clinic Cancer Center Mansfield Mansfield Ohio United States 44906
    446 Hillcrest Hospital Cancer Center Mayfield Heights Ohio United States 44124
    447 UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio United States 44060
    448 UH Seidman Cancer Center at Southwest General Hospital Middleburg Heights Ohio United States 44130
    449 North Coast Cancer Care Sandusky Ohio United States 44870
    450 Springfield Regional Cancer Center Springfield Ohio United States 45504
    451 Springfield Regional Medical Center Springfield Ohio United States 45505
    452 Cleveland Clinic Cancer Center Strongsville Strongsville Ohio United States 44136
    453 Dayton Physicians LLC-Upper Valley Troy Ohio United States 45373
    454 Upper Valley Medical Center Troy Ohio United States 45373
    455 University Hospitals Sharon Health Center Wadsworth Ohio United States 44281
    456 South Pointe Hospital Warrensville Heights Ohio United States 44122
    457 University of Cincinnati Cancer Center-West Chester West Chester Ohio United States 45069
    458 UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio United States 44145
    459 UHHS-Westlake Medical Center Westlake Ohio United States 44145
    460 Cleveland Clinic Wooster Family Health and Surgery Center Wooster Ohio United States 44691
    461 University of Oklahoma Health Sciences Center Oklahoma City Oklahoma United States 73104
    462 Mercy Hospital Oklahoma City Oklahoma City Oklahoma United States 73120
    463 Oklahoma Cancer Specialists and Research Institute-Tulsa Tulsa Oklahoma United States 74146
    464 Saint Alphonsus Medical Center-Baker City Baker City Oregon United States 97814
    465 Saint Charles Health System Bend Oregon United States 97701
    466 Clackamas Radiation Oncology Center Clackamas Oregon United States 97015
    467 Providence Cancer Institute Clackamas Clinic Clackamas Oregon United States 97015
    468 Bay Area Hospital Coos Bay Oregon United States 97420
    469 Providence Newberg Medical Center Newberg Oregon United States 97132
    470 Saint Alphonsus Medical Center-Ontario Ontario Oregon United States 97914
    471 Providence Portland Medical Center Portland Oregon United States 97213
    472 Providence Saint Vincent Medical Center Portland Oregon United States 97225
    473 Kaiser Permanente Northwest Portland Oregon United States 97227
    474 Oregon Health and Science University Portland Oregon United States 97239
    475 Saint Charles Health System-Redmond Redmond Oregon United States 97756
    476 Lehigh Valley Hospital-Cedar Crest Allentown Pennsylvania United States 18103
    477 Lehigh Valley Hospital - Muhlenberg Bethlehem Pennsylvania United States 18017
    478 Bryn Mawr Hospital Bryn Mawr Pennsylvania United States 19010
    479 Christiana Care Health System-Concord Health Center Chadds Ford Pennsylvania United States 19317
    480 Pocono Medical Center East Stroudsburg Pennsylvania United States 18301
    481 Lehigh Valley Hospital-Hazleton Hazleton Pennsylvania United States 18201
    482 Riddle Memorial Hospital Media Pennsylvania United States 19063
    483 Paoli Memorial Hospital Paoli Pennsylvania United States 19301
    484 Phoenixville Hospital Phoenixville Pennsylvania United States 19460
    485 Guthrie Medical Group PC-Robert Packer Hospital Sayre Pennsylvania United States 18840
    486 Lankenau Medical Center Wynnewood Pennsylvania United States 19096
    487 Prisma Health Cancer Institute - Spartanburg Boiling Springs South Carolina United States 29316
    488 Medical University of South Carolina Charleston South Carolina United States 29425
    489 Prisma Health Cancer Institute - Laurens Clinton South Carolina United States 29325
    490 Prisma Health Cancer Institute - Easley Easley South Carolina United States 29640
    491 Prisma Health Cancer Institute - Butternut Greenville South Carolina United States 29605
    492 Prisma Health Cancer Institute - Faris Greenville South Carolina United States 29605
    493 Prisma Health Greenville Memorial Hospital Greenville South Carolina United States 29605
    494 Prisma Health Cancer Institute - Eastside Greenville South Carolina United States 29615
    495 Self Regional Healthcare Greenwood South Carolina United States 29646
    496 Prisma Health Cancer Institute - Greer Greer South Carolina United States 29650
    497 Prisma Health Cancer Institute - Seneca Seneca South Carolina United States 29672
    498 Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota United States 57104
    499 Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota United States 57117-5134
    500 Memorial Hospital Chattanooga Tennessee United States 37404
    501 Baptist Memorial Hospital and Cancer Center-Collierville Collierville Tennessee United States 38017
    502 Pulmonary Medicine Center of Chattanooga-Hixson Hixson Tennessee United States 37343
    503 Baptist Memorial Hospital and Cancer Center-Memphis Memphis Tennessee United States 38120
    504 Baptist Memorial Hospital for Women Memphis Tennessee United States 38120
    505 Memorial GYN Plus Ooltewah Tennessee United States 37363
    506 Saint Joseph Regional Cancer Center Bryan Texas United States 77802
    507 UMC Cancer Center / UMC Health System Lubbock Texas United States 79415
    508 University Hospital San Antonio Texas United States 78229
    509 University of Texas Health Science Center at San Antonio San Antonio Texas United States 78229
    510 Augusta Health Center for Cancer and Blood Disorders Fishersville Virginia United States 22939
    511 Providence Regional Cancer System-Aberdeen Aberdeen Washington United States 98520
    512 MultiCare Auburn Medical Center Auburn Washington United States 98001
    513 Virginia Mason Bainbridge Island Medical Center Bainbridge Island Washington United States 98110
    514 Overlake Medical Center Bellevue Washington United States 98004
    515 PeaceHealth Saint Joseph Medical Center Bellingham Washington United States 98225
    516 Harrison HealthPartners Hematology and Oncology-Bremerton Bremerton Washington United States 98310
    517 Harrison Medical Center Bremerton Washington United States 98310
    518 Highline Medical Center-Main Campus Burien Washington United States 98166
    519 Providence Regional Cancer System-Centralia Centralia Washington United States 98531
    520 Swedish Cancer Institute-Edmonds Edmonds Washington United States 98026
    521 Saint Elizabeth Hospital Enumclaw Washington United States 98022
    522 Providence Regional Cancer Partnership Everett Washington United States 98201
    523 Virginia Mason Federal Way Medical Center Federal Way Washington United States 98002
    524 Saint Francis Hospital Federal Way Washington United States 98003
    525 Tacoma/Valley Radiation Oncology Centers-Gig Harbor Gig Harbor Washington United States 98332
    526 MultiCare Gig Harbor Medical Park Gig Harbor Washington United States 98335
    527 Swedish Cancer Institute-Issaquah Issaquah Washington United States 98029
    528 Kadlec Clinic Hematology and Oncology Kennewick Washington United States 99336
    529 Northwest Cancer Clinic Kennewick Washington United States 99336
    530 Providence Regional Cancer System-Lacey Lacey Washington United States 98503
    531 Saint Clare Hospital Lakewood Washington United States 98499
    532 PeaceHealth Saint John Medical Center Longview Washington United States 98632
    533 Virginia Mason Lynnwood Medical Center Lynnwood Washington United States 98036
    534 Jefferson Healthcare Port Townsend Washington United States 98368
    535 Harrison HealthPartners Hematology and Oncology-Poulsbo Poulsbo Washington United States 98370
    536 Peninsula Cancer Center Poulsbo Washington United States 98370
    537 MultiCare Good Samaritan Hospital Puyallup Washington United States 98372
    538 Tacoma/Valley Radiation Oncology Centers-Puyallup Puyallup Washington United States 98372
    539 Valley Medical Center Renton Washington United States 98055
    540 Virginia Mason Medical Center Seattle Washington United States 98101
    541 Pacific Gynecology Specialists Seattle Washington United States 98104
    542 Swedish Medical Center-Ballard Campus Seattle Washington United States 98107
    543 Seattle Cancer Care Alliance Seattle Washington United States 98109
    544 Kaiser Permanente Washington Seattle Washington United States 98112
    545 Swedish Medical Center-First Hill Seattle Washington United States 98122-4307
    546 Swedish Medical Center-Cherry Hill Seattle Washington United States 98122-5711
    547 University of Washington Medical Center - Montlake Seattle Washington United States 98195
    548 PeaceHealth United General Medical Center Sedro-Woolley Washington United States 98284
    549 Providence Regional Cancer System-Shelton Shelton Washington United States 98584
    550 MultiCare Deaconess Cancer and Blood Specialty Center - Valley Spokane Valley Washington United States 99216
    551 MultiCare Deaconess Cancer and Blood Specialty Center - Downtown Spokane Washington United States 99204
    552 MultiCare Deaconess Cancer and Blood Specialty Center - North Spokane Washington United States 99218
    553 Tacoma/Valley Radiation Oncology Centers-Jackson Hall Tacoma Washington United States 97405
    554 Franciscan Research Center-Northwest Medical Plaza Tacoma Washington United States 98405
    555 MultiCare Tacoma General Hospital Tacoma Washington United States 98405
    556 Northwest Medical Specialties PLLC Tacoma Washington United States 98405
    557 Tacoma/Valley Radiation Oncology Centers-Saint Joe's Tacoma Washington United States 98405
    558 PeaceHealth Southwest Medical Center Vancouver Washington United States 98664
    559 Providence Saint Mary Regional Cancer Center Walla Walla Washington United States 99362
    560 North Star Lodge Cancer Center at Yakima Valley Memorial Hospital Yakima Washington United States 98902
    561 Providence Regional Cancer System-Yelm Yelm Washington United States 98597
    562 Duluth Clinic Ashland Ashland Wisconsin United States 54806
    563 Bellin Memorial Hospital Green Bay Wisconsin United States 54301
    564 Mercyhealth Hospital and Cancer Center - Janesville Janesville Wisconsin United States 53548
    565 Cancer Center of Western Wisconsin New Richmond Wisconsin United States 54017
    566 Billings Clinic-Cody Cody Wyoming United States 82414
    567 Welch Cancer Center Sheridan Wyoming United States 82801
    568 National Cancer Center-Korea Goyang-si Gyeonggi-do Korea, Republic of 410-769
    569 Advance Oncology Center Aguadilla Puerto Rico 00603
    570 Doctor's Cancer Center-Arecibo Arecibo Puerto Rico 00614
    571 Cancer Center-Metro Medical Center Bayamon Bayamon Puerto Rico 00959-5060
    572 Hematologia Oncologia San Pablo Bayamon Puerto Rico 00961
    573 HIMA San Pablo Oncologic Hospital Caguas Puerto Rico 00726
    574 Doctors Cancer Center Manati Puerto Rico 00674
    575 Instituto Oncologia Moderna Ponce Ponce Puerto Rico 00716
    576 San Juan Community Oncology Group San Juan Puerto Rico 00917
    577 Primary Care Physician Group San Juan Puerto Rico 00920
    578 San Juan City Hospital San Juan Puerto Rico 00936
    579 Centro de Hematologia y Oncologia del Sur Santa Isabel Puerto Rico 00757
    580 King Faisal Specialist Hospital and Research Centre Riyadh Saudi Arabia 11211

    Sponsors and Collaborators

    • Southwest Oncology Group
    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Justin Floyd, Southwest Oncology Group

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Southwest Oncology Group
    ClinicalTrials.gov Identifier:
    NCT03418961
    Other Study ID Numbers:
    • S1501
    • NCI-2016-01047
    • S1501
    • SWOG-S1501
    • UG1CA189974
    First Posted:
    Feb 1, 2018
    Last Update Posted:
    Nov 10, 2021
    Last Verified:
    Nov 1, 2021
    Studies a U.S. FDA-regulated Drug Product:
    Yes
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Breast Neoplasms
    Neoplasms
    Cardiotoxicity
    Carvedilol

    Study Results

    No Results Posted as of Nov 10, 2021