Using a Mouthwash Containing Propolis, Clove Oil and Chlorhexidine to Improve the Caries Risk of High Risk Patients
Study Details
Study Description
Brief Summary
This study is conducted to determine if using a mouthwash containing propolis, clove oil and chlorhexidine will improve the caries risk of high risk patients in comparison to using a mouthwash containing chlorhexidine only.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Detailed Description
A total of 64 patients will be assigned in this study. Patients will be randomly divided into two groups according to type of mouthwash (A) where group A1 patients will use chlorhexidine mouthwash as control group while group A2 patients will use chlorhexidine with propolis and clove oil mouthwash as intervention group with 32 patients in each group. Each group will be further divided into two groups according to times of application (T) where T1 represents patients using the mouthwash once daily for one week every month for 6 months and T2 where patients will use the mouthwash twice daily for one week every month for 6 months with 16 patients in each subgroup.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Chlorhexidine Once Daily Chlorhexidine HCL 0.12% mouthwash to be used once daily for one week each month for six months |
Other: Chlorhexidine mouthwash
Chlorhexidine HCL 0.12% mouthwash
|
Active Comparator: Chlorhexidine Twice Daily Chlorhexidine HCL 0.12% mouthwash to be used twice daily for one week each month for six months |
Other: Chlorhexidine mouthwash
Chlorhexidine HCL 0.12% mouthwash
|
Experimental: Propolis Once Daily Chlorhexidine Gluconate 0.12% with Propolis 1% and Clove Oil 1% mouthwash to be used once daily for one week each month for six months |
Other: Chlorhexidine, Propolis and Clove Oil mouthwash
Chlorhexidine Gluconate 0.12% with Propolis 1% and Clove Oil 1% mouthwash
|
Experimental: Propolis Twice Daily Chlorhexidine Gluconate 0.12% with Propolis 1% and Clove Oil 1% mouthwash to be used twice daily for one week each month for six months |
Other: Chlorhexidine, Propolis and Clove Oil mouthwash
Chlorhexidine Gluconate 0.12% with Propolis 1% and Clove Oil 1% mouthwash
|
Outcome Measures
Primary Outcome Measures
- Caries Risk Assessment [6 month]
Patient caries risk assessment will be measured using the cariogram model
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients should be over 18 years of age.
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Patients should be with high caries risk assessment.
Exclusion Criteria:
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Patients with a compromised medical history.
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Severe or active periodontal disease.
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Patients with a diseased salivary gland
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History of allergies or other adverse reactions to chlorhexidine, propolis, bee stings, or clove
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Patients on any antibiotics during the past month
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Conservative Dentistry Department Out-Patient Clinic | Cairo | Egypt | 12613 |
Sponsors and Collaborators
- Moataz Gamal Ali Abdul-Maksoud Konsouh
- Cairo University
Investigators
- Study Director: Mohammad A Ezzat, Ph.D., Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
- Alian AY, McNally ME, Fure S, Birkhed D. Assessment of caries risk in elderly patients using the Cariogram model. J Can Dent Assoc. 2006 Jun;72(5):459-63.
- Anauate Netto C, Marcucci MC, Paulino N, Anido-Anido A, Amore R, de Mendonça S, Borelli Neto L, Bretz WA. Effects of typified propolis on mutans streptococci and lactobacilli: a randomized clinical trial. Braz Dent Sci. 2013 Apr 1;16(2):31-36.
- Autio-Gold J. The role of chlorhexidine in caries prevention. Oper Dent. 2008 Nov-Dec;33(6):710-6. doi: 10.2341/08-3. Review.
- Duailibe SA, Gonçalves AG, Ahid FJ. Effect of a propolis extract on Streptococcus mutans counts in vivo. J Appl Oral Sci. 2007 Oct;15(5):420-3.
- Eley BM. Antibacterial agents in the control of supragingival plaque--a review. Br Dent J. 1999 Mar 27;186(6):286-96. Review.
- Grossman, E., Retter, G., Sturzenberger, O. P., Rosa, M. D. La, Dickinson, T. D., Ferretti, G. A., … Meckel, A. H. (1986). Six-month Study of the Effects of a Chlorhexidine Mouthrinse on Gingivitis in Adults. Journal of Periodontal Research, 33-43.
- Hegde KS, Bhat SS, Rao A, Sain S. Effect of Propolis on Streptococcus mutans Counts: An in vivo Study. Int J Clin Pediatr Dent. 2013 Jan;6(1):22-5. doi: 10.5005/jp-journals-10005-1180. Epub 2013 Apr 26.
- Kim MJ, Kim CS, Kim BH, Ro SB, Lim YK, Park SN, Cho E, Ko JH, Kwon SS, Ko YM, Kook JK. Antimicrobial effect of Korean propolis against the mutans streptococci isolated from Korean. J Microbiol. 2011 Feb;49(1):161-4. doi: 10.1007/s12275-011-1002-8. Epub 2011 Mar 3. Erratum in: J Microbiol. 2011 Apr;49(2)327. Cho, Engene [corrected to Cho, Eugene].
- Libério SA, Pereira AL, Araújo MJ, Dutra RP, Nascimento FR, Monteiro-Neto V, Ribeiro MN, Gonçalves AG, Guerra RN. The potential use of propolis as a cariostatic agent and its actions on mutans group streptococci. J Ethnopharmacol. 2009 Aug 17;125(1):1-9. doi: 10.1016/j.jep.2009.04.047. Epub 2009 May 5. Review.
- SILNESS J, LOE H. PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. Acta Odontol Scand. 1964 Feb;22:121-35.
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