Case-Control Study of Pesticides and Childhood Leukemia

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Completed
CT.gov ID
NCT00342888
Collaborator
(none)
629
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Childhood leukemia is the most common type of childhood cancer and its etiology is largely unknown. Most case-control studies of childhood leukemia have reported elevated risks among children whose parents were occupationally exposed to pesticides or who used pesticides in the home or garden. Investigators at the University of California at Berkeley (UCB) conducted a case-control study of childhood leukemia in 35 counties in the San Francisco Bay area and the agricultural Central Valley of California. A major focus of the UCB study is to evaluate whether household or occupational exposure to pesticides increases the risk of childhood leukemia. Our collaboration provided additional funding to collect carpet dust samples for the measurement of pesticides and other chemicals. For 470 participants, we attempted to collect carpet dust using a special high volume small surface sampler (HVS3) vacuum and by taking dust from participants vacuum cleaner. As of July 2006, dust samples will be collected only from participant's vacuum cleaner. Samples were collected at a home visit approximately 3-6 months after the first in-person interview. We will also provide support for mapping of the crops (i.e., determining crop field boundaries and crop species) within 1200 meters (3/4 mile) of residences so that the residential proximity to agricultural fields treated with pesticides can be determined. We will conduct the epidemiologic analysis of pesticide and other chemical levels in carpet dust and risk of childhood leukemia. We will also evaluate whether residential proximity to agricultural pesticide use is associated with risk of leukemia. Further, we will conduct an Exposure Pilot Study that will include a subset of the study population. Two components of the Pilot Study will evaluate how well a used vacuum bag and a window sill wipe predict pesticide and other chemical concentrations in carpet dust samples collected with the more complicated HVS3 vacuum method. The third component will compare pesticides detected in carpet dust with pesticides predicted by geographic proximity to agriculture.

Condition or DiseaseIntervention/TreatmentPhase

    Detailed Description

    Childhood leukemia is the most common type of childhood cancer and its etiology is largely unknown. Most case-control studies of childhood leukemia have reported elevated risks among children whose parents were occupationally exposed to pesticides or who used pesticides in the home or garden. Investigators at the University of California at Berkeley (UCB) conducted a case-control study of childhood leukemia in 35 counties in the San Francisco Bay area and the agricultural Central Valley of California. A major focus of the UCB study was to evaluate whether household or occupational exposure to pesticides increases the risk of childhood leukemia. Our collaboration provided additional funding to collect carpet dust samples for the measurement of pesticides and other chemicals. For 470 participants, we attempted to collect carpet dust using a special high volume small surface sampler (HVS3) vacuum and by taking dust from participants vacuum cleaner. As of July 2006, dust samples were collected only from participant's vacuum cleaner. Samples were collected at a home visit approximately 3-6 months after the first in-person interview. We also provided support for mapping of the crops (i.e., determining crop field boundaries and crop species) within 1200 meters (3/4 mile) of residences so that the residential proximity to agricultural fields treated with pesticides can be determined. We will conduct the epidemiologic analysis of pesticide and other chemical levels in carpet dust and risk of childhood leukemia. We will also evaluate whether residential proximity to agricultural pesticide use is associated with risk of leukemia. Further, we will conduct an Exposure Pilot Study that will include a subset of the study population. Two components of the Pilot Study will evaluate how well a used vacuum bag and a window sill wipe predict pesticide and other chemical concentrations in carpet dust samples collected with the more complicated HVS3 vacuum method. The third component will compare pesticides detected in carpet dust with pesticides predicted by geographic proximity to agriculture.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    629 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    A Case-Control Study of Pesticides and Childhood Leukemia
    Actual Study Start Date :
    Oct 30, 2001

    Arms and Interventions

    ArmIntervention/Treatment
    Childhood Leukemia Cases

    Cases were diagnosed at 9 hospitals in Northern California

    Matched Controls

    Controls were matched on age, gender and race/ethnicity from birth certificates in Northern California

    Outcome Measures

    Primary Outcome Measures

    1. odds ratios for exposures to environmental contaminants and other factors related to childhood leukemia. [Data analysis still ongoing]

      childhood leukemia

    2. factors associated with concentrations of chemicals including pesticides and persistent organochlorines in house dust samples [Data analysis still ongoing]

      concentrations of the chemicals

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    N/A to 8 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    • INCLUSION CRITERIA:

    All cases and controls were selected from participants in the UCB case-control study who have completed the Tier I interview.

    Study population is limited to children.

    All races and ethnicities will be included in the study.

    Tier I:

    The cases eligible for participation in Tier I of the UCB study of all newly diagnosed cases of childhood leukemia 0-14 years old resident in 35 counties in San Francisco Bay Area and the Central Valley

    Further inclusion criteria are no prior cancer diagnosis and at least one English or Spanish speaking parent.

    Tier II:

    Tier II participants will be selected from cases and controls that complete the Tier I interview. Cases (and their match controls), aged 0-7, diagnosed from December 1, 1999 through 2003, and who still reside at the home where they were living ate the diagnosis date, will be eligible for the Tier II interview.

    Contacts and Locations

    Locations

    SiteCityStateCountryPostal Code
    1University of California, BerkeleyBerkeleyCaliforniaUnited States94720-0001

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Mary Ward, Ph.D., National Cancer Institute (NCI)

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT00342888
    Other Study ID Numbers:
    • 999902030
    • 02-C-N030
    • NCT00556985
    First Posted:
    Jun 21, 2006
    Last Update Posted:
    Apr 8, 2022
    Last Verified:
    Feb 14, 2022
    Keywords provided by National Cancer Institute (NCI)
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Apr 8, 2022