The Visual Plasticity During Adversity and Prosperity in Infants With Congenital Cataracts
Phenotypic plasticity is the ability of individuals to change their phenotypic status when exposed to environmental variations. However, whether the plastic changes show differential susceptibility in adversity and prosperity is debated and the specific pattern of plasticity remains elusive.
Here the investigators address this question by tracking the phenotypes (functional, structural, physical, and attachment traits) in two groups of infants before and after visual deprivation: one group experienced a short duration of complete deprivation (extreme adversity) and the other group experienced a long durations of partial deprivation (watered-down adversity).
|Condition or Disease||Intervention/Treatment||Phase|
Arms and Interventions
|Experimental: dense cataract group|
Procedure: bilateral cataract removal surgery for dense cataract
Participants were born with dense bilateral cataracts (extreme adversity) will undergo surgery for bilateral cataract removal at an early age, mostly around 3 months of age.
|Experimental: non-dense nuclear cataract group|
Procedure: bilateral cataract removal surgery for non-dense nuclear cataract
Participants were born with non-dense and nuclear bilateral cataracts (watered-down adversity) will undergo cataract removal surgery bilaterally in a compromised timing, mostly around one year old.
Primary Outcome Measures
- Change from baseline in visual acuity measured by Teller visual acuity cards [1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery]
Secondary Outcome Measures
- Change from baseline in refractive status measured by autorefractor and objective retinoscopy [1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months and 12 months after surgery]
- Diagnosis with dense or non-dense nuclear congenital cataract
no metabolic diseases, mental retardation or central nervous diseases
had no history of inherited diseases
Contacts and Locations
|1||Zhongshan Ophthalmic Center||Guangzhou||Guangdong||China||510060|
Sponsors and Collaborators
- Sun Yat-sen University
- Principal Investigator: Haotian Lin, Zhongshan Ophthalmic Center, Sun Yat-sen University
Study Documents (Full-Text)None provided.
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