Different Hemostasis According to the Anesthetic Agents

Sponsor

Seoul National University Bundang Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT02151305

Collaborator

(none)

Enrollment

Location

Arms

Duration (Months)

3.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.

Condition or Disease	Intervention/Treatment	Phase
Cataract Retina Detachment Pterygium Keratitis Vitreous Hemorrhage	Drug: Propofol, remifentanil Drug: Sevoflurane	N/A

Study Design

Study Type:

Interventional

Actual Enrollment :

66 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Triple (Participant, Investigator, Outcomes Assessor)

Primary Purpose:

Supportive Care

Official Title:

The Influence of Propofol and Sevoflurane on Hemostasis During Ophthalmic Surgery: Rotational Thromboelastographic Study.

Study Start Date :

Aug 1, 2010

Actual Primary Completion Date :

Apr 1, 2012

Actual Study Completion Date :

Apr 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Total intravenous anesthesia group This group received propofol and remifentanil for the maintenance of general anesthesia.	Drug: Propofol, remifentanil
Experimental: Inhalation anesthesia group This group received sevoflurane for the maintenance of general anesthesia.	Drug: Sevoflurane

Arm

Intervention/Treatment

Experimental: Total intravenous anesthesia group

This group received propofol and remifentanil for the maintenance of general anesthesia.

Drug: Propofol, remifentanil

Experimental: Inhalation anesthesia group

This group received sevoflurane for the maintenance of general anesthesia.

Drug: Sevoflurane

Outcome Measures

Primary Outcome Measures

Clotting time of ROTEM [10 minutes before the induction of anesthesia, 1 h after finishing anesthesia]
Clot firmness time of ROTEM [10 minutes before the induction of anesthesia, 1 h after finishing anesthesia]
Alpha angle of ROTEM [10 minutes before the induction of anesthesia, 1 h after finishing anesthesia]
Maximum clot firmness of ROTEM [10 minutes before the induction of anesthesia, 1 h after finishing anesthesia]

Secondary Outcome Measures

Hemoglobin [10 minutes before the induction of anesthesia]
Hematocrit [10 minutes before the induction of anesthesia]
Platelet count [10 minutes before the induction of anesthesia]
International normalized ratio of prothrombin time [10 minutes before the induction of anesthesia]
Activated partial thromboplastin time [10 minutes before the induction of anesthesia]
Fibrinogen [10 minutes before the induction of anesthesia]