Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study

Sponsor

National Institute of Mental Health (NIMH) (NIH)

Overall Status

Completed

CT.gov ID

NCT00006177

Collaborator

(none)

1,303

Enrollment

Location

Study Details

Study Description

Brief Summary

This research protocol seeks to learn more about bipolar disorder in children and adolescents ages 6-17. Researchers will describe the moods and behaviors of children with bipolar disorder and use specialized testing and brain imaging to learn about specific brain changes associated with the disorder. This protocol studies children who have been diagnosed with bipolar disorder, and those who have a sibling or parent with bipolar disorder and are thus considered "at risk" for developing the disorder....

Condition or Disease	Intervention/Treatment	Phase
Bipolar Disorder Mood Disorders Attention Deficit Hyerpactivity Disorder

Detailed Description

Objective:

For this protocol we define Bipolar Spectrum disorders (BSD) as the propensity to have a manic episode by having Bipolar Disorder or Substance/Medication-Induced Bipolar and Related Disorder. BSD in children and adolescents is receiving increased research attention, but important questions remain about its developmental trajectory, phenomenology and behavioral correlates, and little is known about its underlying neural mechanisms. In its study of youth with BSD, this study has three objectives:

to use longitudinal techniques to characterize the clinical and physiological manifestations of pediatric BSD, and to use cross-sectional techniques (e.g., comparing children and adults with BSD on these measures) to provide preliminary data to guide such longitudinal studies
to identify and follow longitudinally behavioral, neuropsychological, neurophysiological, and neuroanatomical correlates of pediatric BSD, and compare to children with chronic irritability and hyperarousal symptoms (severe mood dysregulation, SMD, as outlined in protocol 02-M-0021), youth with attention deficit hyperactivity disorder (ADHD), and typically developing youth.
to examine genetic and familial correlates of pediatric BSD

Study population:

There are 11 separate populations being studied in this protocol:

Children and adolescents between the ages of 6-17 years old who meet criteria for BSD.
Adults between the ages of 18-58 years old who meet criteria for BD, including those age 18-25 with BSD.
Control populations of: a) Healthy volunteer children and adolescents between the ages of 3-17 years old, b) Parents of healthy volunteer children or healthy adults in research, c) Children 8-17 years old with attention deficit hyperactivity disorder (ADHD), who do not have a mood disorder.
First and second-degree biological relatives of those in (B.1) or (B.2), above, and are between 3-58 years old.
A subgroup of these cohorts will be Old Order Amish individuals who fulfill eligibility for (1), (2), (3a), (3b), or (4).

Design:

For children and adolescents with BSD (i.e. Bipolar Disorder or those with Substance/Medication-Induced Bipolar and Related Disorder), this study is an outpatient characterization and longitudinal follow-along design. Once determined to be eligible, individuals come for an initial assessment, and then at varying intervals they return for clinical interviews, behavioral tasks, and structural and functional MRI.

For children and adolescents who are relatives of individuals with BSD, this is an outpatient follow-along design during which individuals come for an outpatient assessment and at 2-year intervals for clinical interviews, behavioral tasks, and structural and functional MRI.

For healthy volunteer children, children with only ADHD, adults with BD, and parents of healthy volunteer children, this study is an outpatient cross-sectional study that includes clinical interviews, behavioral tasks, and structural and functional MRI.

For all others, individuals come to NIH for clinical interviews, behavioral tasks, and MRI.

For most individuals in the Amish community, the investigation occurs in the field, where they receive clinical interviews and behavioral tasks. Some may choose to come to the NIH to participate in behavioral testing and MRI.

For all individuals, genetic material from saliva or blood is obtained under protocol 01-M-0254.

Outcome measures:

This study will examine between group differences in clinical, behavioral, genetic, neuroanatomical, and neurophysiological variables in individuals with BSD, their relatives, and healthy volunteers. Findings in children with BSD will also be compared to those with severe mood dysregulation, sometimes called a broad phenotype of pediatric BD, recruited under protocol 02-M-0021 (Nottelman, 2001).

Longitudinal clinical, behavioral, and neuroanatomical data will also be obtained.

Study Design

Study Type:

Observational

Actual Enrollment :

1303 participants

Observational Model:

Cohort

Time Perspective:

Other

Official Title:

The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents With Bipolar Disorder

Study Start Date :

Aug 11, 2000

Arms and Interventions

Arm	Intervention/Treatment
Adult bipolar patients Adult bipolar patients
Adult Extended Relatives of BD probands Adult Extended Relatives of BD probands
Bipolar Children and Youth Bipolar Children and Youth
Child/Adolescent Extended Relatives of BD probands Child/Adolescent Extended Relatives of BD probands
Children with ADHD only (controls) Children with ADHD only (controls)
First degree relatives of BD patients First degree relatives of BD patients
Healthy volunteer adults (parents or not) Healthy volunteer adults (parents or not)
Healthy volunteer children and youth Healthy volunteer children and youth

Outcome Measures

Primary Outcome Measures

Objective 1: clinical manifestations [lifetime of protocol]
(1) clinical interviews [e.g., Schedule for Affective Disorders and Schizophrenia for School-Age Children-present and lifetime version, K-SADS-PL, (Kaufman et al., 1997); Structured Clinical Interview for DSM-IV-TR Axis I Disorders, SCID (First et al., 2002)]; (2) clinical and mood rating assessments (e.g., Children's Depression Rating Scale (Poznanski et al., 1984), Young Mania Rating Scale (Young et al., 1978), Pediatric Anxiety Rating (2002), EMA; (3) episode setting via detailed clinical interview at baseline and every 6 month follow up phone call (4) parent-report and self-report [e.g., The Screen for Child Anxiety Related Emotional Disorders SCARED (Birmaher et al., 1997); Social Responsiveness Scale, SRS (Constantino et al., 2003, Granader et al.); Child Behavior Checklist CBCL (Achenbach, 1991)].
Objective 2: behavioral, neuropsychological, neurophysiological, and neuroanatomical correlates [lifetime of protocol]
1) behavioral performance (e.g., accuracy, response time) on tasks assessing attention, emotion, and attention-emotion interactions; (e.g., Stop/Change task, CPT/Flanker, Decision Making tasks) 2) neuropsychological performance (e.g., performance and verbal IQ) 3) brain activation using functional MRI during tasks assessing attention, emotion, and attention-emotion interactions; 4) structural MRI to examine the size, shape and development of grey matter; 5) Diffusion Tensor Imaging (DTI) to measure white matter track myelination; 6) resting state imaging to test functional connectivity between prefrontal regions and the amygdala
Objective 3: genetic and familial correlates [lifetime of protocol]
(1) clinical interviews [e.g., Schedule for Affective Disorders and Schizophrenia for School-Age Children-present and lifetime version, K-SADS-PL, (Kaufman et al., 1997); Structured Clinical Interview for DSM-IV-TR Axis I Disorders, SCID (First et al., 2002)] to examine the rate of various diagnoses in relatives of individuals with BD (2) genetic material to compare genetic polymorphisms in BSD, their relatives and controls (3) relationship between genetic material and performance on behavioral tasks and activation during fMRI paradigms (4) behavioral performance on standardized paradigms; brain activation using functional MRI; size, shape and development of several ROIs using structural MRI; Diffusion Tensor Imaging (DTI); and, Resting State in individuals with a BD relative

Eligibility Criteria

Criteria

Ages Eligible for Study:

3 Years to 58 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

INCLUSION AND EXCLUSION CRITERIA:

Inclusion and exclusion criteria for each group are outlined below. The total accrual ceiling is 2050, including subjects of both sexes, made up of the following 11 populations:

Pediatric patients with bipolar disorder or SMIBRD:

INCLUSION CRITERIA:

Age 6-17
Meet DSM criteria for BD
Have a primary caregiver who can accompany him or her on trips to NIMH and provide reliable history and information.
Have a psychiatrist who provides clinical care for their BSD.
Be able to complete self-rating forms and to cooperate with other study procedures.

EXCLUSION CRITERIA:

I.Q. < 70
Autistic disorder or more than mild autism spectrum disorder;
Psychosis that interferes with the child s capacity to understand and comply with study procedures
Unstable medical illness (e.g. severe asthma)
Medical illness that could cause the symptoms of BSD (e.g. multiple sclerosis, thyroid disease)
Pregnancy
Substance abuse within two months of the initial evaluation, since alcohol and abused substances interfere with interpretation of fMRI and cognitive task data.
NIMH IRP Employee family member

Adults with BD participating as individuals or as parents of at- risk children:

INCLUSION CRITERIA:

DSM Bipolar Disorder
Age 18-58
Be able to complete self-rating forms and to cooperate with other study procedures.
Medically safe to perform MRI

EXCLUSION CRITERIA:

Diagnosis of schizophrenia or other current psychosis.
Claustrophobia or anxiety that prevents participation in MRI
Any serious medical illness, such as heart, liver, or kidney disease.
A history of drug or alcohol abuse in the past 90 days.
Current or past seizure disorder
Currently unstable hyperthyroidism or hypothyroidism
Currently receiving medical treatment that would affect mood, such as steroids
Pregnant or breast-feeding.
Active suicidal or homicidal thoughts or plans
NIMH IRP Employee/family member

Healthy volunteer children and adolescents:

INCLUSION CRITERIA:

Age- and sex- matched to the bipolar patients.
Have an identified primary care physician.
Speaks English

EXCLUSION CRITERIA

I.Q. < 70
Any serious medical condition or condition that interferes with fMRI scanning
Pregnancy
Past or current diagnosis of any anxiety disorder (panic disorder, GAD, Separation Anxiety Disorder, Social Phobia), mood disorder (manic or hypomanic episode, major depression), OCD, PTSD, Conduct Disorder, psychosis, current suicidal ideation, Tourette
Disorder, Autism Spectrum Disorder or ADHD.
Substance abuse within two months prior to study participation or present substance abuse
History of sexual abuse.
Parent or sibling with Bipolar Disorder, recurrent MDD, or any disorder with psychosis.
NIMH IRP Employee family member

Parents of healthy volunteer children (Amish and Non-Amish) and Healthy Adults (not parents):

INCLUSION CRITERIA:

For healthy adults (not parents): Healthy adults age 25-58
For parents of healthy volunteers: Parents of control subjects as outlined in B above
Age 25-58
Speaks English

EXCLUSION CRITERIA:

IQ< 70
Any current psychiatric diagnosis
NIMH IRP Employee/family member

Control subjects with ADHD but not BD:

INCLUSION CRITERIA:

Age 8-17
Currently meets DSM-IV criteria for ADHD
t score >65 on the Connors Parent scales
Subjects with other psychiatric disorders including anxiety disorders, dysthymic disorder, past major depression, oppositional defiant disorder, tic disorders, and the learning, communication, and elimination disorders may be accepted

EXCLUSION CRITERIA

IQ<70
Pregnancy
Ongoing medical illness or neurological disorder other than ADHD
Any condition that would interfere with the participants ability to perform fMRI or other research tasks
Current Major Depression
Any past or present manic or hypomanic episode.
NIMH IRP Employee family member

First- and Second-degree relatives of patients with BD:

INCLUSION CRITERIA:

First degree relatives (parent or sibling) or second-degree relative (grandparent, grandchild, uncle, aunt, nephew, niece, half-sibling) of patients with BD
Age 3-58

EXCLUSION CRITERIA:

Active psychosis
Dementia
IQ < 70
Any clinical condition in need of immediate care
Any chronic medical illness resulting in impaired CNS function
Any condition that interferes with the participants ability to perform research tasks
NIMH IRP Employee/family member

Amish Community children with BD:

INCLUSION CRITERIA:

Age 8-17
Meet DSM-IV criteria for BD
Have a primary caregiver who can provide a reliable history
Be able to complete self-rating forms and to cooperate with other study procedures.

EXCLUSION CRITERIA:

IQ<70
Active psychosis
Any clinical condition in need of immediate care
Any chronic medical illness resulting in impaired CNS function
Any condition that would interfere with the participants ability to perform behavioral research tasks
Limitations with English that would interfere with understanding consent/assent, interview, or task instructions.
NIMH IRP Employee family member

Amish Community Adults with BD:

INCLUSION CRITERIA:

DSM-IV Bipolar Disorder
Age 18-58
Be able to complete self-rating forms and to cooperate with other study procedures.

EXCLUSION CRITERIA:

Diagnosis of schizophrenia or other current psychosis.
Any serious medical illness, such as heart, liver, or kidney disease.
A history of drug or alcohol abuse in the past 90 days.
Current or past seizure disorder
Currently unstable hyperthyroidism or hypothyroidism
Currently receiving medical treatment that would affect mood, such as steroids
Active suicidal or homicidal thoughts or plans
Limitations with English that would interfere with understanding consent/assent, interview, or task instructions.
NIMH IRP Employee/family member

Amish Community at-risk subjects:

INCLUSION CRITERIA:

Age 8-17
Parent or sibling (first-degree relative) diagnosed with BD

EXCLUSION CRITERIA:

IQ<70
Active psychosis
Any clinical condition in need of immediate care
Any chronic medical illness resulting in impaired CNS function
Any condition that would interfere with the participants ability to perform behavioral research tasks
Limitations with English that would interfere with understanding consent/assent, interview, or task instructions.
NIMH IRP Employee family member

Amish Community healthy volunteer children & adolescents:

INCLUSION CRITERIA:

Age 8-17
No serious physical or neurological symptoms or disorder by history

EXCLUSION CRITERIA:

I.Q. < 70
Ongoing medical illness
Neurological disorder (including seizures)
Past or present substance abuse
History of sexual abuse
Limitations with English that would interfere with understanding consent/assent, interview or task instructions
Past or present psychopathology in control subject or their first-degree relative
NIMH IRP Employee family member

Amish Community adults who are parents of healthy volunteer children & adolescents, healthy spouses of Amish adults with BD, or parents of adolescents with BD:

INCLUSION CRITERIA:

Age 18-58
No serious physical or neurological symptoms or disorder by history
For Parents of child with BD or spouses of patient with BD: Spouse or offspring with BD

EXCLUSION CRITERIA:

I.Q. < 70
Ongoing medical illness
Neurological disorder (including seizures)
Past or present substance abuse
History of sexual abuse
Limitations with English that would interfere with understanding consent/assent, interview or task instructions
NIMH IRP Employee/family member
For Healthy volunteers: Past or present psychopathology in participant or their first-degree relative
For Parents of healthy volunteer children: Past or present psychopathology as in (4) above.

In addition, children with BD (Section B.1.) who wish to receive treatment, including discontinuation of medication while inpatients on the pediatric behavioral health unit at

NIH, may be eligible for treatment if they meet the following additional criteria:

All inclusion criteria for B.1 (above)

Treatment failure as defined by current CGAS score <60

The child s psychiatrist/treating physician agrees that a change in medication regimen is appropriate

EXCLUSION CRITERIA:

All exclusion criteria for B.1 (above)

Any contraindications for MRI scanning, plus claustrophobia or extreme separation anxiety

EXCLUSIONS for MRI Scanning:

Pregnancy
Substance abuse within two months of the initial evaluation, since alcohol and abused substances interfere with interpretation of fMRI and cognitive task data.
Claustrophobia or anxiety that prevents participation in MRI
Any serious medical condition or condition that interferes with fMRI scanning
Metal in body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if you were a welder or metal worker, since there may be

small metal fragments in the eye