Children and Adults With Chordoma

Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT03910465
Collaborator
(none)
300
1
128.5
2.3

Study Details

Study Description

Brief Summary

Background:

Chordoma is a rare type of bone cancer. It occurs in the skull base or spine. Researchers want to study people with chordoma in different ways. They hope this will help them design better future treatments and supportive care studies for this disease.

Objective:

To learn more about chordoma by looking at its clinical course, how it appears on imagine scans, and how it responds to therapies and treatments.

Eligibility:

People ages 2 and older with chordoma who are enrolled in NCI protocol 19-C-0016

Design:

Participants will be screened with their medical history.

Participants will have a visit to examine their disease. This will include:
  • Physical exam

  • Neurologic exam

  • CT scan and MRI: Participants will lie on a table. The table will slide into a machine. The machine will take pictures of the body.

Participants will have other tests every 6-12 months:
  • Smell test

  • Surveys to assess their emotional, physical, and behavioral well-being and needs

  • Cognitive function tests

Participants or their home doctors will be contacted every 6 12 months. They will be asked to provide information about their disease. This could include test results and imaging evaluations.

Some participants may be asked to come to the clinic for more visits.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Background:
    • Chordomas are a rare tumor with an incidence of 325 new cases per year in the United States. Pediatric chordomas are very rare and comprise only 5% of all chordoma cases.

    • The standard therapy for localized primary or recurrent chordomas is surgical resection. However, complete surgical resection is often not possible due to the location of the

    chordoma.

    -For chordomas that cannot be surgically resected, treatment options are limited. Currently,

    no standard therapy approach exists for recurrent chordomas. In addition, there are no FDA approved medical therapies for chordoma.

    • The natural history of pediatric and adult chordoma is incompletely understood. Patients with chordoma seek expert advice in the management of their care.

    • The NCI has basic and clinical expertise and research interest in chordoma. The planned natural history study as part of the NCI POB Rare Tumor Patient Engagement Network (RTPEN) will allow for comprehensive evaluation and recommendations to these patients while longitudinally collecting clinical, epidemiologic and biological data.

    Objective:

    -To characterize the natural history of chordoma, including clinical presentation and patterns of disease progression.

    Eligibility:
    • Subjects with histologically documented chordoma.

    • Age greater than or equal to 2 years old

    Design:

    -This protocol is a subprotocol to protocol 19-C-0016: Natural History and Biospecimen

    Acquisition Study for Children and Adults with Rare Solid Tumors . After enrollment on the master protocol and undergoing evaluations detailed, patients will be enrolled on this subprotocol specific for chordoma.

    -Medical histories will be documented, and patients followed throughout the course of their disease, with particular attention to patterns of disease recurrence and progression, response to therapies, duration of responses and patient reported outcomes. Tumor growth rates will also be calculated throughout the course of the disease.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    300 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    Natural History Study of Children and Adults With Chordoma
    Actual Study Start Date :
    Apr 16, 2019
    Anticipated Primary Completion Date :
    Dec 31, 2029
    Anticipated Study Completion Date :
    Dec 31, 2029

    Arms and Interventions

    Arm Intervention/Treatment
    1/Cohort 1

    Subjects with confirmed chordoma.

    Outcome Measures

    Primary Outcome Measures

    1. To characterize the natural history of chordoma, including clinical presentation and patterns of disease progression [10 years]

      Natural history of chordoma, including clinical presentation and patterns of disease progression

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    2 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    • INCLUSION CRITERIA:

    • Ability of subject or Legally Authorized Representative (LAR) to understand and the willingness to sign a written consent document.

    • Subjects with histologically documented chordoma

    • Age greater than or equal to 2 years old

    • Subjects must be enrolled into NCI protocol 19-C-0016: Natural History and Biospecimen Acquisition Study for Children and Adults with Rare Solid Tumors .

    EXCLUSION CRITERIA:

    -None

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 National Institutes of Health Clinical Center Bethesda Maryland United States 20892

    Sponsors and Collaborators

    • National Cancer Institute (NCI)

    Investigators

    • Principal Investigator: Brigitte C Widemann, M.D., National Cancer Institute (NCI)

    Study Documents (Full-Text)

    None provided.

    More Information

    Additional Information:

    Publications

    None provided.
    Responsible Party:
    National Cancer Institute (NCI)
    ClinicalTrials.gov Identifier:
    NCT03910465
    Other Study ID Numbers:
    • 190082
    • 19-C-0082
    First Posted:
    Apr 10, 2019
    Last Update Posted:
    Jul 7, 2022
    Last Verified:
    Mar 10, 2022
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by National Cancer Institute (NCI)
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of Jul 7, 2022