CSHFE: Chinese Second Hip Fracture Evaluation
Study Details
Study Description
Brief Summary
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To Compare overall rates of second hip fractures in both genders,
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To determine the effect of hip fracture on proximal femoral volumetric bone mineral density (vBMD), bone structure and muscle by quantitative computed tomography(QCT),
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To evaluate the contribution of QCT-image analysis to the prediction of the second hip fracture risk.
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To identify the differences between femoral neck fracture and trochanter fracture following hip fracture
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Osteoporotic hip fracture is a great harm among elderly people, for whom disability and death often occurs. Furthermore, sustaining an osteoporotic hip fracture increases the risk of a subsequent fracture. However, the risk factors of subsequent hip fractures are less studied and the proximal femur bone structure and muscle changes following first hip fracture are little known.
Therefore, we propose to conduct an observational and perspective study to assess the effect of hip fracture on proximal femoral bone and muscle using quantitative computed tomography (QCT), as well as to evaluate the contribution of QCT-image analysis to the prediction of the second hip fracture risk. As hip fractures are divided into two major anatomic based types in clinical: femoral neck fractures (intracapsular) and trochanter fractures (extracapsular), the fundamental objective also includes identifying bone and muscle differences in a union activity between the two type fractures. Compared with duel-energy x-ray absorptiometry (DXA), QCT offers the advantage of selective measurement of the metabolically active and structurally important trabecular bone in the proximal femoral. Volumetric BMD and structure of proximal femoral and muscle around hip will be measured with QCT. The CT scanner will be the clinical CT scanner of the local participated center. Quality control and monitoring will be conducted by Beijing Jishuitan hospital, as well as the centralised image interpretation.
Study Design
Outcome Measures
Primary Outcome Measures
- Hip re-fracture [3 years]
The incidence and location of second hip fracture
- all cause death [2 year]
all cause death
Eligibility Criteria
Criteria
Inclusion Criteria:
- a:Osteoporotic patients b:Osteoporotic hip fracture patients (femoral neck fracture and femoral trochanteric fracture) c: Be willing to and be able to join in the study and sighed the informed consent
Exclusion Criteria:
- a:Under 47years old b:Non-surgical repair of hip fracture c:Pathologic fracture d:Violence-related trauma e:Bilateral hip implants or have hip replacement on the non-fractured side
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | Beijing ji shui tan hospital | Beijing | Beijing | China | 100035 |
Sponsors and Collaborators
- Beijing Jishuitan Hospital
Investigators
- Principal Investigator: Xiaoguang Cheng, MD, department of radiology, Beijing Jishuitan Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- JST2016CSHFE