Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis

Sponsor

Riphah International University (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05533931

Collaborator

(none)

Enrollment

Location

Arms

Study Details

Study Description

Brief Summary

The aim of the study is to determine the importance and impact of resistive breathing techniques versus inspiratory hold techniques in patients with chronic bronchitis and specially to find out if there are any changes seen in results measured via the incentive spirometer.

Condition or Disease	Intervention/Treatment	Phase
Chronic Bronchitis	Other: Resistive Breathing Training group Other: inspiratory hold technique	N/A

Detailed Description

Chronic Bronchitis (CB) is defined as a chronic cough and sputum production for at least 3 months a year for 2 consecutive years. It is covered under the umbrella term of Chronic Obstructive Pulmonary Disease (COPD). Chronic bronchitis is thought to be caused by overproduction and hypersecretion of mucus by goblet cells. Epithelial cells lining the airway response to toxic, infectious stimuli by releasing inflammatory mediators and e.g. pro-inflammatory cytokines. During an acute exacerbation of chronic bronchitis, the bronchial mucous membrane becomes hyperemic and edematous with diminished bronchial mucociliary function. This, in turn, leads to airflow impediment because of

luminal obstruction to small airways. The airways become clogged by debris and this further increases the irritation. The characteristic cough of bronchitis is caused by the copious secretion of mucus in chronic bronchitis. Pseudostratified epithelium, highlighting the pseudostratified epithelial cells, goblets cells (shown in blue), then underlying connective tissue.(3) To determine the importance and impact of resistive breathing techniques versus inspiratory hold techniques in patients with chronic bronchitis and specially to find out if there are any changes seen in results measured via incentive spirometer. There are few studies done over it whereas purpose of this research work is to compare these techniques to get better results.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

26 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Comparison of Resistive Breathing Versus Inspiratory Hold Technique in Patients With Chronic Bronchitis

Anticipated Study Start Date :

Sep 1, 2022

Anticipated Primary Completion Date :

Sep 1, 2022

Anticipated Study Completion Date :

Sep 1, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Resistive Breathing Training group The patients performed two sessions each of 15 minutes session of resistive breathing for four days a week for six weeks using an inspiratory resistive device. Ask patient to take long slow inspirations while breathing through the resistive device	Other: Resistive Breathing Training group The patients performed two sessions each of 15 minutes session of resistive breathing for four days a week for six weeks using an inspiratory resistive device. Ask patient to take long slow inspirations while breathing through the resistive device
Active Comparator: inspiratory hold technique With the patient in a comfortable position such as side lying or reclined, the therapist may assist the patient by placing both hands on abdominal area to provide proprioceptive feedback. Then in a relaxed tone of voice therapist instructs the patient to sniff quickly through the nose three times with slow, relaxed exhalations	Other: inspiratory hold technique With the patient in a comfortable position such as side lying or reclined, the therapist may assist the patient by placing both hands on abdominal area to provide proprioceptive feedback. Then in a relaxed tone of voice therapist instructs the patient to sniff quickly through the nose three times with slow, relaxed exhalations

Arm

Intervention/Treatment

Experimental: Resistive Breathing Training group

The patients performed two sessions each of 15 minutes session of resistive breathing for four days a week for six weeks using an inspiratory resistive device. Ask patient to take long slow inspirations while breathing through the resistive device

Other: Resistive Breathing Training group

Active Comparator: inspiratory hold technique

With the patient in a comfortable position such as side lying or reclined, the therapist may assist the patient by placing both hands on abdominal area to provide proprioceptive feedback. Then in a relaxed tone of voice therapist instructs the patient to sniff quickly through the nose three times with slow, relaxed exhalations

Other: inspiratory hold technique

Outcome Measures

Primary Outcome Measures

oxygen saturation [Changes will be assessed at baseline, 3rd week and 6th weeks measured]
amount of oxygen traveling through your body with your red blood cells. Changes will be assessed at baseline, 3rd week and 6th weeks measured
Forced expiratory volume in one second [Changes will be assessed at baseline, 3rd week and 6th weeks measured]
amount of air expired in first one second. Changes will be assessed at baseline, 3rd week and 6th weeks measured
Forced vital capacity [Changes will be assessed at baseline, 3rd week and 6th weeks measured]
the total amount of air exhaled during the FEV test. Changes will be assessed at baseline, 3rd week and 6th weeks measured
FEV1/FVC ratio [6 weeks]
the amount of air exhaled in the first second divided by all of the air exhaled during a maximal exhalation.
shortness of breath measured through borge scale of dyspnea [Changes will be assessed at baseline, 3rd week and 6th weeks measured]
shortness of breath. Changes will be assessed at baseline, 3rd week and 6th weeks measured
SGRQ questionnaire [Changes will be assessed at baseline, 3rd week and 6th weeks measured]
how breathing problems effects quality of life . Changes will be assessed at baseline, 3rd week and 6th weeks measured

Eligibility Criteria

Criteria

Ages Eligible for Study:

45 Years to 60 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

• Diagnosed with chronic bronchitis
Clinically stable patients.
Both genders.
Age 45 to 60 years.
Pink puffers included in this study
Clients that are involved in research are not allowed for other interventional therapies. They can take their regular medications.
Patients diagnosed at least 2 years ago with bronchitis.